日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

p38α介导的磷酸化和PRMT1介导的精氨酸甲基化在驱动TDP-43蛋白病中发挥相反的作用

Aikio, Mari; Odeh, Hana M; Wobst, Heike J; Lee, Bo Lim; Chan, Úna; Mauna, Jocelyn C; Mack, Korrie L; Class, Bradley; Ollerhead, Thomas A; Ford, Alice F; Barbieri, Edward M; Cupo, Ryan R; Drake, Lauren E; Smalley, Joshua L; Lin, Yuan-Ta; Lam, Stephanie; Thomas, Reuben; Castello, Nicholas; Baral, Ashmita; Beyer, Jenna N; Najar, Mohd A; Dunlop, John; Gitler, Aaron D; Javaherian, Ashkan; Kaye, Julia A; Burslem, George M; Brown, Dean G; Donnelly, Christopher J; Finkbeiner, Steven; Moss, Stephen J; Brandon, Nicholas J; Shorter, James

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity.

对人类 Hsp70 网络的深入研究揭示了多种分子伴侣保护机制,可以缓冲 TDP-43 的毒性

Barbieri Edward M, Linsenmeier Miriam, Whiteman Katherine R, Cheng Yan, Braganza Sylvanne, Copley Katie E, Miranda-Castrodad Paola, Lewis Brennen, Villafañe Kevin, Amado Defne A, Davidson Beverly L, Shorter James