日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition

聚乙二醇异构化:一种逃避抗PEG抗体识别的策略

Dreier, Philip; Matthes, Rebecca; Fuß, Fabian; Schmidt, Julian; Schulz, Dominik; Linden, Gregor M; Barent, Ramona D; Schüttner, Sandra; Neun, Barry W; Cedrone, Edward; Dobrovolskaia, Marina A; Bros, Matthias; Frey, Holger

Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations

治疗性siRNA和ASO的转化和临床开发:当前行业实践、观点和建议

Christensen, Jesper Kammersgaard; Colletti, Nicholas; Hooshfar, Shirin; Jiang, Rongrong Rosa; Kuo, Carol; Lindmark, Bosse; Lumen, Annie; Youssef, Amir S; Albertolle, Matthew; Aluri, Krishna C; Chen, Linzhi; Chen, Jingxian; Chopda, Girish; Chua, Xien Yu; Morais, Pedro; Dubois, Barent; Gibbons, Francis Frank; Gudey, Shyam Kumar; Gupta, Swati; Hood, Steve; Humphreys, Sara; Husser, Christophe; Huth, Felix; Jani, Darshana; Jian, Wenying; Kakuda, Thomas; Kurz, Jeffrey; Linnebjerg, Helle; Liu, Jing; Lohmann, Sabine; Niu, Tao; Root, Katharina; Singla, Sumeet; Tang, Chenxiao; Veluri, Ravikanth; Zhang, Guangnong Sunny; Zhang, Steven; Jawa, Vibha

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.

针对 cAMP 偏向信号传导优化的 GLP-1 类似物可改善肥胖小鼠的体重减轻

Douros Jonathan D, Novikoff Aaron, DuBois Barent, Rohlfs Rebecca, Mokrosinski Jacek, Hogendorf Wouter F J, Augustin Robert, Merkestein Myrte, Egaa Martini Lene Brandt, Linderoth Lars, Gerrard Elliot, Kodra Janos Tibor, Norlin Jenny, Roed Nikolaj Kulahin, Oldenburger Anouk, Mowery Stephanie A, Waldhoer Maria, Perez-Tilve Diego, Finan Brian, Reedtz-Runge Steffen, Müller Timo D, Knerr Patrick J

Electrodiagnostic Assessment of Peri-Procedural Iatrogenic Peripheral Nerve Injuries and Rehabilitation

电诊断评估围手术期医源性周围神经损伤及康复

Seidel, Geoffrey K; Vocelle, Amber R; Ackers, Ian S; Scott, Kenneth A; Carl, Curtis A; Bradt, Barent A G; Dumitru, Daniel; Andary, Michael T

A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice

长效 LEAP2 类似物可减轻小鼠肝脏脂肪变性和炎症,并导致体重明显减轻

Kripa Shankar, Nathan P Metzger, Connor Lawrence, Deepali Gupta, Sherri Osborne-Lawrence, Salil Varshney, Omprakash Singh, Corine P Richard, Alexander N Zaykov, Rebecca Rolfts, Barent N DuBois, Diego Perez-Tilve, Bharath K Mani, Suntrea T G Hammer, Jeffrey M Zigman

Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis-Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes

腹腔注射硫代乙酰胺诱发慢性肝硬化对大鼠肝微粒体蛋白质含量及细胞色素P450酶米氏动力学的影响

Devaraj Venkatapura Chandrashekar, Barent N DuBois, Mamunur Rashid, Reza Mehvar

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

GLP-1 介导的替沙格列扎递送可改善雄性小鼠的肥胖和葡萄糖代谢

Carmelo Quarta #, Kerstin Stemmer #, Aaron Novikoff #, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J Drucker, Barent DuBois, Annette Feuchtinger

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

发现一种对啮齿动物和人类系统有效的强效 GIPR 肽拮抗剂

Bin Yang, Vasily M Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J Knerr, David D'Alessio, Jonathan E Campbell, Jonathan D Douros, Brian Finan

The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells

泛素连接酶 RNF138 与 CtIP 协同刺激人类 G1 期细胞中复杂 DNA 双链断裂的切除

Nicole B Averbeck, Carina Barent, Burkhard Jakob, Tatyana Syzonenko, Marco Durante, Gisela Taucher-Scholz