Bargonetti相关文献与解析，生知库 | 链接生命科学的每一步

Xiao Gu, Annor George K, Harmon Katherine W, Chavez Valery, Levine Fayola, Ahuno Samuel, Atmane Mohamed I, St Jean Samantha, Madorsky Rowdo Florencia P, Leybengrub Pamella, Gaglio AnnMarie, Ellison Viola, Venkatesh Divya, Sun Siyu, Merghoub Taha, Greenbaum Benjamin, Elemento Olivier, Davis Melissa B, Ogunwobi Olorunseun, Bargonetti Jill

乳腺癌

肿瘤

P53

PARP

发表日期：2026

文献求助收藏

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation

脂肪生成酶 FASN 通过棕榈酰化促进突变 p53 积累和功能获得

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-57099-9

Juan Liu, Yiyun Shen, Jie Liu, Dandan Xu, Chun-Yuan Chang, Jianming Wang, Jason Zhou, Bruce G Haffty, Lanjing Zhang, Jill Bargonetti, Subhajyoti De, Wenwei Hu, Zhaohui Feng

Ki-67

发表日期：2025

文献求助收藏

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.

由 MDM2、MDM4 (MDMX) 和突变 p53 驱动的癌症持续性 DNA 修复回路，用于在染色质上募集 MDC1 和 53BP1

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf627

Ellison Viola, Polotskaia Alla, Xiao Gu, Leybengrub Pamella, Lee Rusia, Qiu Weigang, Hendrickson Ronald C, Hu Wenwei, Bargonetti Jill

p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome

p53抑制肠上皮细胞MHC II类分子的呈递，从而预防辐射诱发的胃肠道综合征。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-44390-w

Jianming Wang ，Chun-Yuan Chang ，Xue Yang ，Fan Zhou ，Juan Liu ，Jill Bargonetti ，Lanjing Zhang ，Ping Xie ，Zhaohui Feng ，Wenwei Hu

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

携带 p53 突变（而非野生型 p53）的患者来源肿瘤类器官对 PARP 抑制剂的协同联合治疗敏感。

期刊:Cancer Letters

影响因子:10.1

doi:10.1016/j.canlet.2024.216608

Madorsky Rowdo, Florencia P; Xiao, Gu; Khramtsova, Galina F; Nguyen, John; Martini, Rachel; Stonaker, Brian; Boateng, Richard; Oppong, Joseph K; Adjei, Ernest K; Awuah, Baffour; Kyei, Ishmael; Aitpillah, Frances S; Adinku, Michael O; Ankomah, Kwasi; Osei-Bonsu, Ernest B; Gyan, Kofi K; Altorki, Nasser K; Cheng, Esther; Ginter, Paula S; Hoda, Syed; Newman, Lisa; Elemento, Olivier; Olopade, Olufunmilayo I; Davis, Melissa B; Martin, M Laura; Bargonetti, Jill

Chemokine CXCL12 Activates CXC Receptor 4 Metastasis Signaling Through the Upregulation of a CXCL12/CXCR4/MDMX (MDM4) Axis

趋化因子 CXCL12 通过上调 CXCL12/CXCR4/MDMX (MDM4) 轴激活 CXC 受体 4 转移信号

期刊:Cancers

影响因子:

doi:10.3390/cancers16244194

Rusia Lee, Viola Ellison, Dominique Forbes, Chong Gao, Diana Katanov, Alexandra Kern, Fayola Levine, Pam Leybengrub, Olorunseun Ogunwobi, Gu Xiao, Zhaohui Feng, Jill Bargonetti

信号转导

发表日期：2024

文献求助收藏

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

由 MDM2、MDM4 (MDMX) 和突变型 P53 驱动的癌症持久性 DNA 修复回路，用于募集 MDC1 和 53BP1 至染色质

期刊:

影响因子:

doi:10.1101/2024.01.20.576487

Viola Ellison, Alla Polotskaia, Gu Xiao, Pamella Leybengrub, Weigang Qiu, Rusia Lee, Ronald Hendrickson, Wenwei Hu, Jill Bargonetti

The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose

获得功能突变 p53 R273H 的 C 端是与 PARP1 和聚 ADP 核糖结合所必需的

期刊:Molecular Cancer Research

影响因子:4.1

doi:10.1158/1541-7786.MCR-22-0133

Devon Lundine #, George K Annor #, Valery Chavez, Styliana Maimos, Zafar Syed, Shuhong Jiang, Viola Ellison, Jill Bargonetti

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

小分子MMRi62靶向MDM4使其降解，并诱导白血病细胞凋亡，且该作用不受p53状态的影响。

期刊:Frontiers in Oncology

影响因子:3.3

doi:10.3389/fonc.2022.933446

Lama, Rati; Xu, Chao; Galster, Samuel L; Querol-García, Javier; Portwood, Scott; Mavis, Cory K; Ruiz, Federico M; Martin, Diana; Wu, Jin; Giorgi, Marianna C; Bargonetti, Jill; Wang, Eunice S; Hernandez-Ilizaliturri, Francisco J; Koudelka, Gerald B; Chemler, Sherry R; Muñoz, Inés G; Wang, Xinjiang

Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities

突变 p53 R273H 的寡聚化不是获得功能染色质相关活动的必要条件

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.6

doi:10.3389/fcell.2021.772315

George K Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.

突变型 p53 指导 PARP 调节复制压力并驱动乳腺癌转移。

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation

脂肪生成酶 FASN 通过棕榈酰化促进突变 p53 积累和功能获得

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.

由 MDM2、MDM4 (MDMX) 和突变 p53 驱动的癌症持续性 DNA 修复回路，用于在染色质上募集 MDC1 和 53BP1

p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome

p53抑制肠上皮细胞MHC II类分子的呈递，从而预防辐射诱发的胃肠道综合征。

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

携带 p53 突变（而非野生型 p53）的患者来源肿瘤类器官对 PARP 抑制剂的协同联合治疗敏感。

Chemokine CXCL12 Activates CXC Receptor 4 Metastasis Signaling Through the Upregulation of a CXCL12/CXCR4/MDMX (MDM4) Axis

趋化因子 CXCL12 通过上调 CXCL12/CXCR4/MDMX (MDM4) 轴激活 CXC 受体 4 转移信号

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

由 MDM2、MDM4 (MDMX) 和突变型 P53 驱动的癌症持久性 DNA 修复回路，用于募集 MDC1 和 53BP1 至染色质

The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose

获得功能突变 p53 R273H 的 C 端是与 PARP1 和聚 ADP 核糖结合所必需的

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

小分子MMRi62靶向MDM4使其降解，并诱导白血病细胞凋亡，且该作用不受p53状态的影响。

Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities

突变 p53 R273H 的寡聚化不是获得功能染色质相关活动的必要条件