日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.

突变型 p53 指导 PARP 调节复制压力并驱动乳腺癌转移。

Xiao Gu, Annor George K, Harmon Katherine W, Chavez Valery, Levine Fayola, Ahuno Samuel, Atmane Mohamed I, St Jean Samantha, Madorsky Rowdo Florencia P, Leybengrub Pamella, Gaglio AnnMarie, Ellison Viola, Venkatesh Divya, Sun Siyu, Merghoub Taha, Greenbaum Benjamin, Elemento Olivier, Davis Melissa B, Ogunwobi Olorunseun, Bargonetti Jill

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.

由 MDM2、MDM4 (MDMX) 和突变 p53 驱动的癌症持续性 DNA 修复回路,用于在染色质上募集 MDC1 和 53BP1

Ellison Viola, Polotskaia Alla, Xiao Gu, Leybengrub Pamella, Lee Rusia, Qiu Weigang, Hendrickson Ronald C, Hu Wenwei, Bargonetti Jill

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

携带 p53 突变(而非野生型 p53)的患者来源肿瘤类器官对 PARP 抑制剂的协同联合治疗敏感。

Madorsky Rowdo, Florencia P; Xiao, Gu; Khramtsova, Galina F; Nguyen, John; Martini, Rachel; Stonaker, Brian; Boateng, Richard; Oppong, Joseph K; Adjei, Ernest K; Awuah, Baffour; Kyei, Ishmael; Aitpillah, Frances S; Adinku, Michael O; Ankomah, Kwasi; Osei-Bonsu, Ernest B; Gyan, Kofi K; Altorki, Nasser K; Cheng, Esther; Ginter, Paula S; Hoda, Syed; Newman, Lisa; Elemento, Olivier; Olopade, Olufunmilayo I; Davis, Melissa B; Martin, M Laura; Bargonetti, Jill

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

小分子MMRi62靶向MDM4使其降解,并诱导白血病细胞凋亡,且该作用不受p53状态的影响。

Lama, Rati; Xu, Chao; Galster, Samuel L; Querol-García, Javier; Portwood, Scott; Mavis, Cory K; Ruiz, Federico M; Martin, Diana; Wu, Jin; Giorgi, Marianna C; Bargonetti, Jill; Wang, Eunice S; Hernandez-Ilizaliturri, Francisco J; Koudelka, Gerald B; Chemler, Sherry R; Muñoz, Inés G; Wang, Xinjiang

A Protein in the Yeast Saccharomyces cerevisiae Presents DNA Binding Homology to the p53 Checkpoint Protein and Tumor Suppressor

酿酒酵母中的一种蛋白质与p53检查点蛋白和肿瘤抑制蛋白具有DNA结合同源性

Farooqi, Kanwal; Ghazvini, Marjan; Pride, Leah D; Mazzella, Louis; White, David; Pramanik, Ajay; Bargonetti, Jill; Moore, Carol Wood

MDM2-C Functions as an E3 Ubiquitin Ligase

MDM2-C 发挥 E3 泛素连接酶的功能

Kim, Jun Yeob; Lee, Rusia; Xiao, Gu; Forbes, Dominique; Bargonetti, Jill

Gain-of-function mutant p53: history and speculation

功能获得性突变 p53:历史与推测

Bargonetti, Jill; Prives, Carol

MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population

MDM2、MDM2-C 和突变型 p53 的表达影响多民族人群中乳腺癌患者的生存率

Loo, Lenora W M; Gao, Chong; Shvetsov, Yurii B; Okoro, Danielle R; Hernandez, Brenda Y; Bargonetti, Jill

Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis

关于MDMX(MDM4)驱动三阴性乳腺癌循环肿瘤细胞和转移的思考

Gao, Chong; Xiao, Gu; Bargonetti, Jill

Impedimetric detection of mutant p53 biomarker-driven metastatic breast cancers under hyposmotic pressure

在低渗压力下,利用阻抗法检测突变型p53生物标志物驱动的转移性乳腺癌

Shi, Menglu; Shtraizent, Nataly; Polotskaia, Alla; Bargonetti, Jill; Matsui, Hiroshi