日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and mechanism of negative allosteric modulation of the α7 nicotinic acetylcholine receptor by nanobodies.

纳米抗体对α7尼古丁乙酰胆碱受体负变构调节的发现和机制。

Barilone Nathalie, Vangelatou Maria, Marouf F Zahra, Dejean de la Bâtie Gabrielle, Li Qimeng, Lafaye Pierre, Aymé Gabriel, Corringer Pierre-Jean, Prevost Marie S

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

人类 α7 烟碱受体与纳米抗体复合的低温电子显微镜结构揭示的原始增强机制

Marie S Prevost #, Nathalie Barilone #, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer0

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

生成可作为α7尼古丁乙酰胆碱受体的沉默正向变构调节剂的纳米抗体

Li, Qimeng; Nemecz, Ákos; Aymé, Gabriel; Dejean de la Bâtie, Gabrielle; Prevost, Marie S; Pons, Stéphanie; Barilone, Nathalie; Baachaoui, Rayen; Maskos, Uwe; Lafaye, Pierre; Corringer, Pierre-Jean

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

利用串联体重新研究α5在α4β2尼古丁受体中的作用

Prevost, Marie S; Bouchenaki, Hichem; Barilone, Nathalie; Gielen, Marc; Corringer, Pierre-Jean

A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG

四肽重复支架通过蛋白激酶 PknG 将信号检测与 OdhI 磷酸化偶联,从而调控代谢。

Lisa, María-Natalia; Sogues, Adrià; Barilone, Nathalie; Baumgart, Meike; Gil, Magdalena; Graña, Martín; Durán, Rosario; Biondi, Ricardo M; Bellinzoni, Marco; Bott, Michael; Alzari, Pedro M

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

噻吩甲酰胺衍生物经乙胺酸活化后,通过抑制CTP合成酶PyrG杀死结核分枝杆菌。

Mori, Giorgia; Chiarelli, Laurent R; Esposito, Marta; Makarov, Vadim; Bellinzoni, Marco; Hartkoorn, Ruben C; Degiacomi, Giulia; Boldrin, Francesca; Ekins, Sean; de Jesus Lopes Ribeiro, Ana Luisa; Marino, Leonardo B; Centárová, Ivana; Svetlíková, Zuzana; Blaško, Jaroslav; Kazakova, Elena; Lepioshkin, Alexander; Barilone, Nathalie; Zanoni, Giuseppe; Porta, Alessio; Fondi, Marco; Fani, Renato; Baulard, Alain R; Mikušová, Katarína; Alzari, Pedro M; Manganelli, Riccardo; de Carvalho, Luiz Pedro S; Riccardi, Giovanna; Cole, Stewart T; Pasca, Maria Rosalia

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis

结核分枝杆菌中阿拉伯半乳聚糖半乳糖胺取代基的生物合成起源

Skovierová, Henrieta; Larrouy-Maumus, Gérald; Pham, Ha; Belanová, Martina; Barilone, Nathalie; Dasgupta, Arunava; Mikusová, Katarina; Gicquel, Brigitte; Gilleron, Martine; Brennan, Patrick J; Puzo, Germain; Nigou, Jérôme; Jackson, Mary

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

AftD,一种来自分枝杆菌的新型必需阿拉伯呋喃糖基转移酶

Skovierová, Henrieta; Larrouy-Maumus, Gérald; Zhang, Jian; Kaur, Devinder; Barilone, Nathalie; Korduláková, Jana; Gilleron, Martine; Guadagnini, Stéphanie; Belanová, Martina; Prevost, Marie-Christine; Gicquel, Brigitte; Puzo, Germain; Chatterjee, Delphi; Brennan, Patrick J; Nigou, Jérôme; Jackson, Mary

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra

结核分枝杆菌H37Ra中双组分调节因子PhoP-PhoR的点突变导致聚酮类衍生的酰基海藻糖的缺失,但并不影响邻苯二酚二霉菌酸酯的缺失。

Chesne-Seck, Marie-Laure; Barilone, Nathalie; Boudou, Frédéric; Gonzalo Asensio, Jesús; Kolattukudy, Pappachan E; Martín, Carlos; Cole, Stewart T; Gicquel, Brigitte; Gopaul, Deshmukh N; Jackson, Mary

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

Ser/Thr蛋白激酶PknB对于维持分枝杆菌的生长至关重要。

Fernandez, Pablo; Saint-Joanis, Brigitte; Barilone, Nathalie; Jackson, Mary; Gicquel, Brigitte; Cole, Stewart T; Alzari, Pedro M