文献库，生知库 | 链接生命科学的每一步

日期影响因子

PD-1 blockade enhances functional vaccine-induced HIV-1 CD8(+) T-cell responses in PWH receiving early ART

PD-1阻断可增强接受早期抗逆转录病毒疗法的HIV-1感染者体内功能性疫苗诱导的HIV-1 CD8(+) T细胞反应。

期刊:EBioMedicine

doi:10.1016/j.ebiom.2025.106070

Marin, Miguel; Ruiz, Alba; Ouchi, Dan; Jimenez-Moyano, Esther; Peña, Ruth; Blanch-Lombarte, Oscar; Gorman, Dan; Barnard, Richard; Hanke, Tomas; Clotet, Bonaventura; Howell, Bonnie; Brander, Christian; Mothe, Beatriz; Prado, Julia G

细胞生物学

免疫/内分泌

发表日期：2026

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

重新定义组蛋白去乙酰化酶抑制剂药效团：高效且无锌辅因子相互作用

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.1c00074

Beshore, Douglas C; Adam, Gregory C; Barnard, Richard J O; Burlein, Christine; Gallicchio, Steven N; Holloway, M Katharine; Krosky, Daniel; Lemaire, Wei; Myers, Robert W; Patel, Sangita; Plotkin, Michael A; Powell, David A; Rada, Vanessa; Cox, Christopher D; Coleman, Paul J; Klein, Daniel J; Wolkenberg, Scott E

发表日期：2021

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Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group

基于2-取代苯甲酰胺锌结合基团的高选择性和高效HDAC3抑制剂的发现

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.0c00462

Liu, Jian; Yu, Younong; Kelly, Joseph; Sha, Deyou; Alhassan, Abdul-Basit; Yu, Wensheng; Maletic, Milana M; Duffy, Joseph L; Klein, Daniel J; Holloway, M Katharine; Carroll, Steve; Howell, Bonnie J; Barnard, Richard J O; Wolkenberg, Scott; Kozlowski, Joseph A

发表日期：2020

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Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence

超感染和感染细胞的治愈是丙型肝炎病毒适应和持续存在的机制

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1805267115

Ke, Ruian; Li, Hui; Wang, Shuyi; Ding, Wenge; Ribeiro, Ruy M; Giorgi, Elena E; Bhattacharya, Tanmoy; Barnard, Richard J O; Hahn, Beatrice H; Shaw, George M; Perelson, Alan S

细胞生物学

发表日期：2018

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Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells.

潜伏期逆转后抗原的产生以及 CD8+ T 细胞中抑制性受体的表达限制了 HIV-1 再激活细胞的杀伤

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2018.03162

Ruiz Alba, Blanch-Lombarte Oscar, Jimenez-Moyano Esther, Ouchi Dan, Mothe Beatriz, PeÃ±a Ruth, Galvez Cristina, GenescÃ Meritxell, Martinez-Picado Javier, Goulder Philip, Barnard Richard, Howell Bonnie, Clotet Bonaventura, Prado Julia G

细胞生物学

发表日期：2018

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Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials

BENCHMRK 研究中拉替拉韦治疗 HIV 感染 5 年的疗效和安全性：两项随机、安慰剂对照试验的最终结果

期刊:Lancet Infectious Diseases

影响因子:31

doi:10.1016/S1473-3099(13)70093-8

Eron, Joseph J; Cooper, David A; Steigbigel, Roy T; Clotet, Bonaventura; Gatell, Jose M; Kumar, Princy N; Rockstroh, Jurgen K; Schechter, Mauro; Markowitz, Martin; Yeni, Patrick; Loutfy, Mona R; Lazzarin, Adriano; Lennox, Jeffrey L; Strohmaier, Kim M; Wan, Hong; Barnard, Richard Jo; Nguyen, Bach-Yen T; Teppler, Hedy

发表日期：2013

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Long-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 Phase III trials

拉替拉韦联合优化背景疗法治疗既往接受过治疗的耐药性 HIV 感染患者的长期疗效和安全性：BENCHMRK 1 和 2 III 期试验第 96 周结果

期刊:Clinical Infectious Diseases

影响因子:7.3

doi:10.1086/650002

Steigbigel, Roy T; Cooper, David A; Teppler, Hedy; Eron, Joseph J; Gatell, Jose M; Kumar, Princy N; Rockstroh, Jurgen K; Schechter, Mauro; Katlama, Christine; Markowitz, Martin; Yeni, Patrick; Loutfy, Mona R; Lazzarin, Adriano; Lennox, Jeffrey L; Clotet, Bonaventura; Zhao, Jing; Wan, Hong; Rhodes, Rand R; Strohmaier, Kim M; Barnard, Richard J; Isaacs, Robin D; Nguyen, Bach-Yen T

发表日期：2010

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Raltegravir versus Efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses

在初治 HIV-1 感染患者中，拉替拉韦与依非韦伦方案的比较：96 周疗效、持久性、亚组、安全性和代谢分析

期刊:Jaids-Journal of Acquired Immune Deficiency Syndromes

影响因子:2.2

doi:10.1097/QAI.0b013e3181da1287

Lennox, Jeffrey L; Dejesus, Edwin; Berger, Daniel S; Lazzarin, Adriano; Pollard, Richard B; Ramalho Madruga, Jose Valdez; Zhao, Jing; Wan, Hong; Gilbert, Christopher L; Teppler, Hedy; Rodgers, Anthony J; Barnard, Richard J O; Miller, Michael D; Dinubile, Mark J; Nguyen, Bach-Yen; Leavitt, Randi; Sklar, Peter

发表日期：2010

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Two retroviral entry pathways distinguished by lipid raft association of the viral receptor and differences in viral infectivity

逆转录病毒的两种入侵途径，区别在于病毒受体与脂筏的结合情况以及病毒感染力的差异。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/jvi.77.3.1977-1983.2003

Narayan, Shakti; Barnard, Richard J O; Young, John A T

发表日期：2003

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