日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology

一种能穿透血脑屏障的P2X7R拮抗剂可减轻阿尔茨海默病病理。

Turcu, Andreea L; Oken, Adam C; Griñán-Ferré, Christian; Durner, Anna; Sierra-Marquez, Juan; Hinz-Kowalik, Sonja; Nagel, Jessica; Lee, So-Deok; Tzortzini, Efpraxia; Georgiou, Kyriakos; Bhol, Mamina; Baz, Zuriñe; Llop, Jordi; Schneider, Marion; Barbaraci, Carla; Kim, Ga-Ram; Barniol-Xicota, Marta; Val, Cristina; Brea, José; Loza, M Isabel; Pérez, Belén; Naesens, Lieve; Kolocouris, Antonios; Kim, Yong-Chul; Müller, Christa E; Nicke, Annette; Pallàs, Mercè; Mansoor, Steven E; Vázquez, Santiago

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor

基于结构的药物设计鉴定出的一种多环骨架能有效抑制人P2X7受体。

Oken, Adam C; Turcu, Andreea L; Tzortzini, Eva; Georgiou, Kyriakos; Nagel, Jessica; Westermann, Franka G; Barniol-Xicota, Marta; Seidler, Jonas; Kim, Ga-Ram; Lee, So-Deok; Nicke, Annette; Kim, Yong-Chul; Müller, Christa E; Kolocouris, Antonios; Vázquez, Santiago; Mansoor, Steven E

Macrocyclic Phage Display for Identification of Selective Protease Substrates

大环噬菌体展示技术用于鉴定选择性蛋白酶底物

Faucher, Franco F; Blažková, Kristýna; Lovell, Scott; Bertolini, Matilde; Herrero-Bourdieu, Juan; Cosco, Emily D; Bogyo, Matthew; Barniol-Xicota, Marta

Exogenous prion-like proteins and their potential to trigger cognitive dysfunction.

外源性朊病毒样蛋白及其引发认知功能障碍的潜力

Seira Curto Jofre, Dominguez Martinez Adan, Perez Collell Genis, Barniol Simon Estrella, Romero Ruiz Marina, Franco Bordés Berta, Sotillo Sotillo Paula, Villegas Hernandez Sandra, Fernandez Maria Rosario, Sanchez de Groot Natalia

Macrocyclic phage display for identification of selective protease substrates

利用大环噬菌体展示技术鉴定选择性蛋白酶底物

Faucher, Franco F; Lovell, Scott; Bertolini, Matilde; Blažková, Kristýna; Cosco, Emily D; Bogyo, Matthew; Barniol-Xicota, Marta

4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL

4-氧代-β-内酰胺类化合物作为线粒体内膜蛋白酶PARL的共价抑制剂

Ji, Shanping; Bach, Kathrin; Miriyala, Vijay Madhav; Dohnálek, Jan; Riopedre-Fernandez, Miguel; Lepšík, Martin; van de Plassche, Merel; Vanhoutte, Roeland; Barniol-Xicota, Marta; Moreira, Rui; Strisovsky, Kvido; Verhelst, Steven H L

Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets

表面活性剂稳定液滴中SMALP的包封形成脂质囊泡

Waeterschoot, Jorik; Barniol-Xicota, Marta; Verhelst, Steven; Baatsen, Pieter; Koos, Erin; Lammertyn, Jeroen; Casadevall I Solvas, Xavier

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

基于氮杂肽活性的SARS-CoV-2主蛋白酶探针能够可视化感染细胞中的抑制情况。

Vanhoutte, Roeland; Barniol-Xicota, Marta; Chiu, Winston; Vangeel, Laura; Jochmans, Dirk; De Jonghe, Steven; Zidane, Hadeer; Barr, Haim M; London, Nir; Neyts, Johan; Verhelst, Steven H L

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

苯并高金刚烷基脲类药物的合成、体外分析和体内评价,用于治疗内脏痛:可溶性环氧化物水解酶抑制剂的新适应症

Sandra Codony, José M Entrena, Carla Calvó-Tusell, Beatrice Jora, Rafael González-Cano, Sílvia Osuna, Rubén Corpas, Christophe Morisseau, Belén Pérez, Marta Barniol-Xicota, Christian Griñán-Ferré, Concepción Pérez, María Isabel Rodríguez-Franco, Antón L Martínez, M Isabel Loza, Mercè Pallàs, Steven

Lipidomic and in-gel analysis of maleic acid co-polymer nanodiscs reveals differences in composition of solubilized membranes.

对马来酸共聚物纳米盘进行脂质组学和凝胶内分析,揭示了溶解膜成分的差异

Barniol-Xicota Marta, Verhelst Steven H L