日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

PTEN 和 PIK3CA 的共存改变会过度激活子宫内膜癌中的 mTORC1 信号通路,并导致其对 mTORC1 抑制剂的选择性敏感性。

Solomon, Hilla; Mukherjee, Radha; Yang, Yu Chi; Meredith, Julia; Schram, Alison M; Yi, Sang Ah; Chen, Xiaoping; Tribuzio, Michael; Gundlapalli, Harika; Meyerowitz, Justin; de Stanchina, Elisa; Weigelt, Britta; An, Heeseon; Barry, Simon T; Smith, Jacqueline A M; Singh, Mallika; Rosen, Neal

Probing intratumoral metabolic compartmentalisation in a patient with fumarate hydratase-deficient renal cancer using clinical hyperpolarised (13)C-MRI and mass spectrometry imaging

利用临床超极化(13)C-MRI和质谱成像技术,探测富马酸水合酶缺陷型肾癌患者的肿瘤内代谢区室化。

Horvat-Menih, Ines; Casey, Ruth; Denholm, James; Hamm, Gregory; Hulme, Heather; Gallon, John; Khan, Alixander S; Kaggie, Joshua; Gill, Andrew B; Priest, Andrew N; Duarte, Joao A G; Yong, Cissy; Brodie, Cara; Whitworth, James; Barry, Simon T; Goodwin, Richard J A; Anand, Shubha; Dodd, Marc; Honan, Katherine; Welsh, Sarah J; Warren, Anne Y; Aho, Tevita; Stewart, Grant D; Mitchell, Thomas J; McLean, Mary A; Gallagher, Ferdia A

Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer

空间代谢组学为临床影像学在提高筛状前列腺癌检测方面的应用提供了信息。

Sushentsev, Nikita; Hamm, Gregory; Manavaki, Roido; McLean, Mary A; Birchall, Jonathan; Soloviev, Dmitry; Lewis, David Y; Aloj, Luigi; Flint, Lucy; Zakirov, Aleksandr; Mills, Ian G; Gnanapragasam, Vincent J; Warren, Anne Y; Barry, Simon T; Goodwin, Richard J A; Gallagher, Ferdia A; Barrett, Tristan

The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer.

FOXO3 和 FOXM1 之间的相互作用会影响 PIK3CA 和 PIK3CA/PTEN 改变的雌激素受体阳性乳腺癌对 AKT 抑制的敏感性

Cutano Valentina, Chia Ming Li, Wigmore Eleanor M, Hopcroft Lorna, Williamson Stuart C, Christie Amanda L, Willis Brandon, Kerr James, Ashforth Jenny, Fox Rhys, D'Arcy Sophie, Bradshaw Lauren, Blaker Catherine, Eberlein Cath, Montava-Garriga Lambert, de Bruin Elza C, Critchlow Susan E, Brindle Kevin M, Barry Simon T, Ros Susana

Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition.

利用代谢成像技术监测治疗性 mTORC1/2 通路抑制后肿瘤反应的异质性

Ling Stephanie, Dexter Alex, Race Alan M, Sharma Shreya, Hamm Gregory, Polanska Urszula M, Marshall John F, Takats Zoltan, Brindle Kevin, Yuneva Mariia O, Poulogiannis George, Campbell Andrew D, Sansom Owen J, Goodwin Richard J A, Bunch Josephine, Barry Simon T

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

组织病理学生物标志物在预测纳米药物肿瘤蓄积中的应用

May, Jan-Niklas; Moss, Jennifer I; Mueller, Florian; Golombek, Susanne K; Biancacci, Ilaria; Rizzo, Larissa; Elshafei, Asmaa Said; Gremse, Felix; Pola, Robert; Pechar, Michal; Etrych, Tomáš; Becker, Svea; Trautwein, Christian; Bülow, Roman D; Boor, Peter; Knuechel, Ruth; von Stillfried, Saskia; Storm, Gert; Puri, Sanyogitta; Barry, Simon T; Schulz, Volkmar; Kiessling, Fabian; Ashford, Marianne B; Lammers, Twan

Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer.

Capivasertib 与多西他赛联合使用,通过抑制前列腺癌中 AKT 介导的生存机制来增强抗肿瘤活性

Eberlein Cath, Williamson Stuart C, Hopcroft Lorna, Ros Susana, Moss Jennifer I, Kerr James, van Weerden Wytske M, de Bruin Elza C, Dunn Shanade, Willis Brandon, Ross Sarah J, Rooney Claire, Barry Simon T

Targeting IL-8 and Its Receptors in Prostate Cancer: Inflammation, Stress Response, and Treatment Resistance

靶向IL-8及其受体治疗前列腺癌:炎症、应激反应和治疗耐药性

McClelland, Shauna; Maxwell, Pamela J; Branco, Cristina; Barry, Simon T; Eberlein, Cath; LaBonte, Melissa J

Population Pharmacokinetics of Capivasertib in Patients with Advanced or Metastatic Solid Tumours

卡帕替尼在晚期或转移性实体瘤患者中的群体药代动力学

Fernandez-Teruel, Carlos; Cullberg, Marie; Eberlein, Cath; Barry, Simon T; Zhou, Diansong

Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence

肿瘤乳酸成像可用于识别术后生化复发的中危前列腺癌患者。

Sushentsev, Nikita; Hamm, Gregory; Richings, Jack; McLean, Mary A; Menih, Ines Horvat; Ayyappan, Vinay; Mills, Ian G; Warren, Anne Y; Gnanapragasam, Vincent J; Barry, Simon T; Goodwin, Richard J A; Gallagher, Ferdia A; Barrett, Tristan