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New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices

准确评估循环活性转化生长因子-β1 水平的新方法：对评估心力衰竭和左心室辅助装置的影响的意义

doi:10.1016/j.trsl.2017.10.006

Donna Mancini, Juan Monteagudo, Mayte Suárez-Fariñas, Jeffrey Bander, Rohan Varshney, Juana Gonzalez, Barry S Coller, Jasimuddin Ahamed

Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: Evidence of systemic activation of platelet-derived TGF-β1 and correlation with cardiac dysfunction

主动脉瓣狭窄小鼠模型中循环白细胞和血小板白细胞聚集体中 Smad2/3 磷酸化增加：血小板衍生 TGF-β1 全身激活的证据及其与心脏功能障碍的相关性

期刊:Blood Cells Molecules and Diseases

影响因子:2.1

doi:10.1016/j.bcmd.2016.01.007

Wei Wang, Nathalie Burg, Spandana Vootukuri, Barry S Coller

Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation

鉴定硫醇异构酶结合肽 mastoparan 为剪切诱导转化生长因子 β1 (TGF-β1) 活化的新型抑制剂

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M112.439034

Teresa M Brophy, Barry S Coller, Jasimuddin Ahamed

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

压力超负荷小鼠模型中血小板 TGF-β1 对血浆 TGF-β1、心脏纤维化和收缩功能障碍的贡献

期刊:Blood

影响因子:21

doi:10.1182/blood-2011-09-377648

Alexander Meyer, Wei Wang, Jiaxiang Qu, Lori Croft, Jay L Degen, Barry S Coller, Jasimuddin Ahamed

Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3

αIIb 膝部限制延伸对配体与整合素 αIIbbeta3 结合的影响

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M110.107763

Robert Blue, Jihong Li, Jonathan Steinberger, Marta Murcia, Marta Filizola, Barry S Coller

发表日期：2010

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Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist

从新型 alphaIIb 特异性 alphaIIbbeta3 拮抗剂的物种特异性和体内抗血栓活性获得结构和治疗见解

期刊:Blood

影响因子:21

doi:10.1182/blood-2008-08-169243

Robert Blue, M Anna Kowalska, Jessica Hirsch, Marta Murcia, Christin A Janczak, Amanda Harrington, Marketa Jirouskova, Jihong Li, Rudy Fuentes, Michael A Thornton, Marta Filizola, Mortimer Poncz, Barry S Coller

心血管

发表日期：2009

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In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1

体外和体内证据表明血小板反应蛋白-1 (TSP-1) 有助于血小板衍生的 TGF-β1 的搅拌和剪切依赖性激活

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0006608

Jasimuddin Ahamed, Christin A Janczak, Knut M Wittkowski, Barry S Coller

Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen

应用高通量筛选鉴定一种新型 alphaIIb 特异性小分子抑制剂，以抑制 alphaIIbbeta3 介导的血小板与纤维蛋白原的相互作用

期刊:Blood

影响因子:21

doi:10.1182/blood-2007-08-105544

Robert Blue, Marta Murcia, Charles Karan, Markéta Jirousková, Barry S Coller

血小板

发表日期：2008

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In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1

体外和体内证据表明剪切诱导潜在转化生长因子-β1 的激活

期刊:Blood

影响因子:21

doi:10.1182/blood-2008-04-151753

Jasimuddin Ahamed, Nathalie Burg, Keiji Yoshinaga, Christin A Janczak, Daniel B Rifkin, Barry S Coller

信号转导

发表日期：2008

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Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer

αIIbβ3 在血小板与交联纤维蛋白片段 D-二聚体的相互作用中起主导作用

New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices

准确评估循环活性转化生长因子-β1 水平的新方法：对评估心力衰竭和左心室辅助装置的影响的意义

Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic valve stenosis: Evidence of systemic activation of platelet-derived TGF-β1 and correlation with cardiac dysfunction

主动脉瓣狭窄小鼠模型中循环白细胞和血小板白细胞聚集体中 Smad2/3 磷酸化增加：血小板衍生 TGF-β1 全身激活的证据及其与心脏功能障碍的相关性

Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation

鉴定硫醇异构酶结合肽 mastoparan 为剪切诱导转化生长因子 β1 (TGF-β1) 活化的新型抑制剂

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

压力超负荷小鼠模型中血小板 TGF-β1 对血浆 TGF-β1、心脏纤维化和收缩功能障碍的贡献

Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3

αIIb 膝部限制延伸对配体与整合素 αIIbbeta3 结合的影响

Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist

从新型 alphaIIb 特异性 alphaIIbbeta3 拮抗剂的物种特异性和体内抗血栓活性获得结构和治疗见解

In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1

体外和体内证据表明血小板反应蛋白-1 (TSP-1) 有助于血小板衍生的 TGF-β1 的搅拌和剪切依赖性激活

Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen

应用高通量筛选鉴定一种新型 alphaIIb 特异性小分子抑制剂，以抑制 alphaIIbbeta3 介导的血小板与纤维蛋白原的相互作用

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1

体外和体内证据表明剪切诱导潜在转化生长因子-β1 的激活