日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intestinal macrophages modulate synucleinopathy along the gut-brain axis.

肠道巨噬细胞通过肠-脑轴调节突触核蛋白病。

De Schepper Sebastiaan, Konstantellos Viktoras, Conway James A, Sokolova Dimitra, Zaccagnini Ludovica, Cowley Matthew V, Sierksma Annerieke, Yudina Maria, Edmonds Marisa, Gavriouchkina Daria, Geary Bethany, Wallis Amber, Celikag Meral, Baykam Zeynep, Vara-Pérez Mónica, Crowley Gerard, Hager Fabian Tobias, Bijnen Mitchell, Posner David, Luk Kelvin, Cerovic Vuk, Clatworthy Menna, Videlock Elizabeth J, Jaunmuktane Zane, Movahedi Kiavash, Greter Melanie, Chain Benny, Alessi Dario R, Hong Soyon, Bartels Tim

Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies.

路易体痴呆症患者的脑细胞质中高分子量α-突触核蛋白寡聚体增多。

Gregersen Emil, Antorini Mia R, Reimer Lasse, Zaccagnini Ludovica, Selkoe Dennis, Bartels Tim, Jensen Poul Henning

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.

基因表达网络中罕见风险变异负担的增加会导致散发性帕金森病

Eubanks Elena, VanderSleen Katelyn, Mody Jiya, Patel Neha, Sacks Benjamin, Farahani Mahsa Darestani, Wang Jinying, Elliott Jordan, Jaber Nora, Akçimen Fulya, Bandres-Ciga Sara, Helweh Fadel, Liu Jun, Archakam Sanjana, Kimelman Robert, Sharma Bineet, Socha Philip, Guntur Ananya, Huang Yiming, Ramalingam Nagendran, Guadagno Elyse, Bartels Tim, Dettmer Ulf, Mouradian M Maral, Bahrami Amir Houshang, Dai Wei, Baum Jean, Shi Zheng, Hardy John, Kara Eleanna

Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis

脂滴促进α-突触核蛋白异常的液-液相分离,导致能量稳态受损。

Cevallos, Jose; Eubanks, Elena; Jung, Sunghoo; Huang, Yiming; Guadagno, Elyse; Suvvari, Neeharika Rao; Doshi, Aryan; Ravinutala, Nitya; Mosera, Alejandro; Ramalingam, Nagendran; Tripathi, Arati; Bartels, Tim; Dettmer, Ulf; Kara, Eleanna

Acute introduction of monomeric or multimeric α-synuclein induces distinct impacts on synaptic vesicle trafficking at lamprey giant synapses.

单体或多聚体α-突触核蛋白的急性引入对七鳃鳗巨型突触的突触小泡运输产生不同的影响

Román-Vendrell Cristina, Wallace Jaqulin N, Watson Aurelia Hays, Celikag Meral, Bartels Tim, Morgan Jennifer R

ExPLAining early synucleinopathies

解释早期突触核蛋白病

Dettmer, Ulf; Bartels, Tim

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity

从人脑中纯化α-突触核蛋白揭示了内源性多聚体在蛋白质纯度接近饱和时表现出的不稳定性。

Luth, Eric S; Bartels, Tim; Dettmer, Ulf; Kim, Nora C; Selkoe, Dennis J

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

可溶性Aβ寡聚体在体内能迅速从脑组织间液中分离出来,并与细胞膜上的GM1神经节苷脂结合。

Hong, Soyon; Ostaszewski, Beth L; Yang, Ting; O'Malley, Tiernan T; Jin, Ming; Yanagisawa, Katsuhiko; Li, Shaomin; Bartels, Tim; Selkoe, Dennis J

The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding

固有无序蛋白α-突触核蛋白的N端触发膜结合和螺旋折叠。

Bartels, Tim; Ahlstrom, Logan S; Leftin, Avigdor; Kamp, Frits; Haass, Christian; Brown, Michael F; Beyer, Klaus