日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A randomized, blinded study of photobiomodulation in a mouse model of Alzheimer's disease showed no preventive effect

一项在阿尔茨海默病小鼠模型中进行的光生物调节随机双盲研究表明,光生物调节没有预防作用。

Sipion, Mélanie; Ferreira, Filipa M; Scholler, Jules; Brana, Corinne; Gora, Michalina; Kouvas, George; Barthet, Gael; Sobolewski, Aleksander

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

早老素介导 EphrinB 和脑源性神经营养因子的神经保护功能,并调节 EphB2 和 TrkB 受体的配体诱导内化和代谢。

Barthet, Gael; Dunys, Julie; Shao, Zhiping; Xuan, Zhao; Ren, Yimin; Xu, Jindong; Arbez, Nicolas; Mauger, Gweltas; Bruban, Julien; Georgakopoulos, Anastasios; Shioi, Junichi; Robakis, Nikolaos K

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

γ-分泌酶底物选择、加工和毒性的细胞机制

Barthet, Gael; Georgakopoulos, Anastasios; Robakis, Nikolaos K

Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein

早老素1/γ-分泌酶通过调节与糖鞘脂富集微区相关的磷蛋白/Csk结合蛋白,促进EphB2诱导的EphrinB2磷酸化。

Georgakopoulos, Anastasios; Xu, Jindong; Xu, Chijie; Mauger, Gweltas; Barthet, Gael; Robakis, Nikolaos K

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

γ-分泌酶抑制剂可稳定该复合物,并对淀粉样前体蛋白和其他底物的加工产生不同的影响

Barthet Gael, Shioi Junichi, Shao Zhiping, Ren Yimin, Georgakopoulos Anastasios, Robakis Nikolaos K

p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.

p120 连环蛋白募集钙黏蛋白至γ-分泌酶,抑制Aβ肽的产生

Kouchi Zen, Barthet Gael, Serban Geo, Georgakopoulos Anastasios, Shioi Junichi, Robakis Nikolaos K