日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells

癌细胞端粒维持机制的大规模药物敏感性、基因依赖性和蛋白质组学分析

Wu, Yangxiu; Cai, Zhaoxiang; Cross, Dale; Noble, Jane R; Prest, Kelsy; Littleboy, Jamie; Cohen, Scott B; Edlundh, Baylee; Koh, Jennifer M S; Xu, Ran; Noor, Zainab; Bastami, Milad; Valentini, Sara; Richardson, Laura; Barthorpe, Syd; Arymanesh, Nader; Robinson, Phillip J; Hains, Peter G; Garnett, Mathew J; Zhong, Qing; Reddel, Roger R; MacKenzie, Karen L

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level

泛癌筛选可在个体和群体水平上识别癌细胞系中的药物组合获益。

Vis, Daniel J; Jaaks, Patricia; Aben, Nanne; Coker, Elizabeth A; Barthorpe, Syd; Beck, Alexandra; Hall, Caitlin; Hall, James; Lightfoot, Howard; Lleshi, Ermira; Mironenko, Tatiana; Richardson, Laura; Tolley, Charlotte; Garnett, Mathew J; Wessels, Lodewyk F A

Establishment and Characterization of an Epstein-Barr Virus-positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

从非角化分化型原发性鼻咽癌中建立和鉴定EB病毒阳性细胞系

Chai, Annie Wai Yeeng; Yee, Shi Mun; Lee, Hui Mei; Abdul Aziz, Norazlin; Yee, Pei San; Marzuki, Marini; Wong, Ka Wo; Chiang, Alan K S; Chow, Larry Ka-Yue; Dai, Wei; Liu, Teng Fei; Tan, Lu Ping; Khoo, Alan Soo Beng; Lo, Kwok Wai; Lim, Paul V H; Rajadurai, Pathmanathan; Lightfoot, Howard; Barthorpe, Syd; Garnett, Mathew J; Cheong, Sok Ching

High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

TNF 和 NF-κB 通路的高依赖性与 OSCC 中 AZD5582 的敏感性相关,该过程通过 CASP8 依赖性细胞凋亡实现。

Chai, Annie Wai Yeeng; Tan, Yee Hua; Ooi, Shiyin; Yee, Pei San; Yee, Shi Mun; Lightfoot, Howard; Barthorpe, Syd; Garnett, Mathew J; Cheong, Sok Ching

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

用于高效大规模癌症类器官培养和扰动筛选的悬浮技术

Price, Stacey; Bhosle, Shriram; Gonçalves, Emanuel; Li, Xiaodun; McClurg, Dylan P; Barthorpe, Syd; Beck, Alex; Hall, Caitlin; Lightfoot, Howard; Farrow, Luke; Ansari, Rizwan; Jackson, David A; Allen, Laura; Roberts, Kirsty; Beaver, Charlotte; Francies, Hayley E; Garnett, Mathew J

Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models

细胞模型护照——临床前癌症模型的临床、遗传和功能数据集中心

van der Meer, Dieudonne; Barthorpe, Syd; Yang, Wanjuan; Lightfoot, Howard; Hall, Caitlin; Gilbert, James; Francies, Hayley E; Garnett, Mathew J

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

全基因组化学诱变筛选能够对癌症基因组进行无偏饱和处理,并识别耐药突变。

Brammeld, Jonathan S; Petljak, Mia; Martincorena, Inigo; Williams, Steven P; Alonso, Luz Garcia; Dalmases, Alba; Bellosillo, Beatriz; Robles-Espinoza, Carla Daniela; Price, Stacey; Barthorpe, Syd; Tarpey, Patrick; Alifrangis, Constantine; Bignell, Graham; Vidal, Joana; Young, Jamie; Stebbings, Lucy; Beal, Kathryn; Stratton, Michael R; Saez-Rodriguez, Julio; Garnett, Mathew; Montagut, Clara; Iorio, Francesco; McDermott, Ultan

Patterns of somatic mutation in human cancer genomes

人类癌症基因组中的体细胞突变模式

Greenman, Christopher; Stephens, Philip; Smith, Raffaella; Dalgliesh, Gillian L; Hunter, Christopher; Bignell, Graham; Davies, Helen; Teague, Jon; Butler, Adam; Stevens, Claire; Edkins, Sarah; O'Meara, Sarah; Vastrik, Imre; Schmidt, Esther E; Avis, Tim; Barthorpe, Syd; Bhamra, Gurpreet; Buck, Gemma; Choudhury, Bhudipa; Clements, Jody; Cole, Jennifer; Dicks, Ed; Forbes, Simon; Gray, Kris; Halliday, Kelly; Harrison, Rachel; Hills, Katy; Hinton, Jon; Jenkinson, Andy; Jones, David; Menzies, Andy; Mironenko, Tatiana; Perry, Janet; Raine, Keiran; Richardson, Dave; Shepherd, Rebecca; Small, Alexandra; Tofts, Calli; Varian, Jennifer; Webb, Tony; West, Sofie; Widaa, Sara; Yates, Andy; Cahill, Daniel P; Louis, David N; Goldstraw, Peter; Nicholson, Andrew G; Brasseur, Francis; Looijenga, Leendert; Weber, Barbara L; Chiew, Yoke-Eng; DeFazio, Anna; Greaves, Mel F; Green, Anthony R; Campbell, Peter; Birney, Ewan; Easton, Douglas F; Chenevix-Trench, Georgia; Tan, Min-Han; Khoo, Sok Kean; Teh, Bin Tean; Yuen, Siu Tsan; Leung, Suet Yi; Wooster, Richard; Futreal, P Andrew; Stratton, Michael R

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

编码泛素E3连接酶亚基的CUL4B基因突变会导致一种X连锁智力低下综合征,该综合征伴有攻击性爆发、癫痫发作、相对性巨头畸形、中心性肥胖、性腺功能减退、高弓足和震颤。

Tarpey, Patrick S; Raymond, F Lucy; O'Meara, Sarah; Edkins, Sarah; Teague, Jon; Butler, Adam; Dicks, Ed; Stevens, Claire; Tofts, Calli; Avis, Tim; Barthorpe, Syd; Buck, Gemma; Cole, Jennifer; Gray, Kristian; Halliday, Kelly; Harrison, Rachel; Hills, Katy; Jenkinson, Andrew; Jones, David; Menzies, Andrew; Mironenko, Tatiana; Perry, Janet; Raine, Keiran; Richardson, David; Shepherd, Rebecca; Small, Alexandra; Varian, Jennifer; West, Sofie; Widaa, Sara; Mallya, Uma; Moon, Jenny; Luo, Ying; Holder, Susan; Smithson, Sarah F; Hurst, Jane A; Clayton-Smith, Jill; Kerr, Bronwyn; Boyle, Jackie; Shaw, Marie; Vandeleur, Lucianne; Rodriguez, Jayson; Slaugh, Rachel; Easton, Douglas F; Wooster, Richard; Bobrow, Martin; Srivastava, Anand K; Stevenson, Roger E; Schwartz, Charles E; Turner, Gillian; Gecz, Jozef; Futreal, P Andrew; Stratton, Michael R; Partington, Michael

Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus

ZDHHC9基因的突变(该基因编码NRAS和HRAS的棕榈酰转移酶)会导致X连锁智力低下,并伴有马凡氏体征。

Raymond, F Lucy; Tarpey, Patrick S; Edkins, Sarah; Tofts, Calli; O'Meara, Sarah; Teague, Jon; Butler, Adam; Stevens, Claire; Barthorpe, Syd; Buck, Gemma; Cole, Jennifer; Dicks, Ed; Gray, Kristian; Halliday, Kelly; Hills, Katy; Hinton, Jonathon; Jones, David; Menzies, Andrew; Perry, Janet; Raine, Keiran; Shepherd, Rebecca; Small, Alexandra; Varian, Jennifer; Widaa, Sara; Mallya, Uma; Moon, Jenny; Luo, Ying; Shaw, Marie; Boyle, Jackie; Kerr, Bronwyn; Turner, Gillian; Quarrell, Oliver; Cole, Trevor; Easton, Douglas F; Wooster, Richard; Bobrow, Martin; Schwartz, Charles E; Gecz, Jozef; Stratton, Michael R; Futreal, P Andrew