Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury.
利用软骨素酶基因疗法进行大规模硫酸软骨素蛋白聚糖消化,可减少脊髓挫伤后的病理变化并调节巨噬细胞表型
期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.4369-13.2014
Bartus Katalin, James Nicholas D, Didangelos Athanasios, Bosch Karen D, Verhaagen Joost, Yáñez-Muñoz Rafael J, Rogers John H, Schneider Bernard L, Muir Elizabeth M, Bradbury Elizabeth J