日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design and Synthesis of BLU-654, a Potent and Selective Mutant KIT V654A Inhibitor for the Treatment of Imatinib-Resistant GIST

设计并合成了BLU-654,一种高效且选择性的KIT V654A突变体抑制剂,用于治疗伊马替尼耐药的胃肠道间质瘤(GIST)。

Moine, Ludivine; Hu, Wei; Davis, Alison; Perola, Emanuele; Guo, Jian; Barvian, Kevin; Choi, Yeon Sook; Grassian, Alexandra; Kim, Joseph L; Ahmad, Omar K; Dineen, Thomas A

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

应对无法治愈的淋病难题:ETX0914,一种具有独特作用机制、可对抗细菌 II 型拓扑异构酶的首创药物

Basarab, Gregory S; Kern, Gunther H; McNulty, John; Mueller, John P; Lawrence, Kenneth; Vishwanathan, Karthick; Alm, Richard A; Barvian, Kevin; Doig, Peter; Galullo, Vincent; Gardner, Humphrey; Gowravaram, Madhusudhan; Huband, Michael; Kimzey, Amy; Morningstar, Marshall; Kutschke, Amy; Lahiri, Sushmita D; Perros, Manos; Singh, Renu; Schuck, Virna J A; Tommasi, Ruben; Walkup, Grant; Newman, Joseph V