日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration

PhP.B 在全身给药或直接脑给药后增强腺相关病毒介导的表达

Kimberly L Pietersz, Francois Du Plessis, Stephan M Pouw, Jolanda M Liefhebber, Sander J van Deventer, Gerard J M Martens, Pavlina S Konstantinova, Bas Blits

Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss

病毒介导的胶质源性神经营养因子过度表达引起年龄和剂量依赖性的神经元毒性和听力损失

Omar Akil, Bas Blits, Lawrence R Lustig, Patricia A Leake

In-Depth Characterization of a Mifepristone-Regulated Expression System for AAV5-Mediated Gene Therapy in the Liver

深入表征米非司酮调控的 AAV5 介导的肝脏基因治疗表达系统

Jolanda M Liefhebber, Raygene Martier, Tom Van der Zon, Sonay Keskin, Angelina Huseinovic, Jacek Lubelski, Bas Blits, Harald Petry, Pavlina Konstantinova

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model

AAV5-miHTT 基因疗法在亨廷顿病小型猪模型中表现出广泛分布和强效降低人类突变型亨廷顿蛋白的作用

Melvin M Evers, Jana Miniarikova, Stefan Juhas, Astrid Vallès, Bozena Bohuslavova, Jana Juhasova, Helena Kupcova Skalnikova, Petr Vodicka, Ivona Valekova, Cynthia Brouwers, Bas Blits, Jacek Lubelski, Hana Kovarova, Zdenka Ellederova, Sander J van Deventer, Harald Petry, Jan Motlik, Pavlina Konstanti

Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy

将针对载脂蛋白 B100 的 siRNA 序列嵌入 shRNA 和 miRNA 支架中可实现差异化处理和体内疗效

Piotr Maczuga, Jacek Lubelski, Richard van Logtenstein, Florie Borel, Bas Blits, Erwin Fakkert, Adalberto Costessi, Derek Butler, Sander van Deventer, Harald Petry, Annemart Koornneef, Pavlina Konstantinova

Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice

通过 AAV 递送的 shRNA 敲低载脂蛋白 B 可降低小鼠血浆胆固醇

Annemart Koornneef, Piotr Maczuga, Richard van Logtenstein, Florie Borel, Bas Blits, Tita Ritsema, Sander van Deventer, Harald Petry, Pavlina Konstantinova

Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes

移植 BDNF 分泌间充质干细胞为慢性高血压大鼠眼提供神经保护

Matthew M Harper, Sinisa D Grozdanic, Bas Blits, Markus H Kuehn, Daniel Zamzow, Janice E Buss, Randy H Kardon, Donald S Sakaguchi

Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells

工程间充质干细胞释放的脑源性神经营养因子可减轻谷氨酸和过氧化氢介导的星形孢菌素分化 RGC-5 细胞死亡

Matthew M Harper, Laura Adamson, Bas Blits, Mary Bartlett Bunge, Sinisa D Grozdanic, Donald S Sakaguchi