日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Negamycin: Nature's Forgotten Antibiotic

奈加霉素:被大自然遗忘的抗生素

Boyle, Grant A; Basarab, Gregory S

Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum

基于细胞的螺吲哚啉表型先导化合物筛选,最终鉴定出针对人类疟原虫恶性疟原虫具有不同寄生虫学特征的化合物。

Dam, Jean; Boyle, Grant A; Horatscheck, André; Woodland, John G; Le Manach, Claire; Kaur, Gurminder; Taylor, Dale; Krugmann, Liezl; Njoroge, Mathew; Lawrence, Nina; Brunschwig, Christel; Zdorichenko, Victor; Cox, Brian; Wittlin, Sergio; von Geldern, Thomas W; Smith, Dennis; Duffy, James; Basarab, Gregory S; Chibale, Kelly

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.

设计新型巯基-3-苯基丙酰二肽作为双重血管紧张素转换酶C结构域选择性/脑啡肽酶抑制剂

Cozier Gyles E, Coulson Lauren B, Eyermann Charles J, Basarab Gregory S, Schwager Sylva L, Chibale Kelly, Sturrock Edward D, Acharya K Ravi

Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria

在人源化小鼠疟疾模型中对疟原虫磷脂酰肌醇 4-激酶抑制剂进行剂量分割研究

Gibhard, Liezl; Njoroge, Mathew; Mulubwa, Mwila; Lawrence, Nina; Smith, Dennis; Duffy, James; Le Manach, Claire; Brunschwig, Christel; Taylor, Dale; van der Westhuyzen, Renier; Street, Leslie J; Basarab, Gregory S; Chibale, Kelly

Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting

佐利氟达辛与淋病奈瑟菌DNA促旋酶和拓扑异构酶IV的相互作用:细胞靶向的酶学基础

Collins, Jessica A; Basarab, Gregory S; Chibale, Kelly; Osheroff, Neil

Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception?

21世纪以消旋药物形式开发的抗感染药物:是常态还是例外?

Cabrera, Diego González; Smith, Dennis A; Basarab, Gregory S; Duffy, James; Spangenberg, Thomas; Chibale, Kelly

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

螺嘧啶三酮类:一类对结核分枝杆菌具有活性且与氟喹诺酮类药物无交叉耐药性的DNA促旋酶抑制剂

Basarab, Gregory S; Ghorpade, Sandeep; Gibhard, Liezl; Mueller, Rudolf; Njoroge, Mathew; Peton, Nashied; Govender, Preshendren; Massoudi, Lisa M; Robertson, Gregory Thomas; Lenaerts, Anne J; Boshoff, Helena Ingrid; Joerss, Douglas; Parish, Tanya; Durand-Reville, Thomas F; Perros, Manos; Singh, Vinayak; Chibale, Kelly

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"

Brunschwig 等人的论文“UCT943,一种用于治疗疟疾的下一代恶性疟原虫 PI4K 抑制剂临床前候选药物”的勘误

Brunschwig, Christel; Lawrence, Nina; Taylor, Dale; Abay, Efrem; Njoroge, Mathew; Basarab, Gregory S; Le Manach, Claire; Paquet, Tanya; Gonzàlez Cabrera, Diego; Nchinda, Aloysius T; de Kock, Carmen; Wiesner, Lubbe; Denti, Paolo; Waterson, David; Blasco, Benjamin; Leroy, Didier; Witty, Michael J; Donini, Cristina; Duffy, James; Wittlin, Sergio; White, Karen L; Charman, Susan A; Jiménez-Díaz, Maria Belén; Angulo-Barturen, Iñigo; Herreros, Esperanza; Gamo, Francisco Javier; Rochford, Rosemary; Mancama, Dalu; Coetzer, Theresa L; van der Watt, Mariëtte E; Reader, Janette; Birkholtz, Lyn-Marie; Marsh, Kennan C; Solapure, Suresh M; Burke, John E; McPhail, Jacob A; Vanaerschot, Manu; Fidock, David A; Fish, Paul V; Siegl, Peter; Smith, Dennis A; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Silue, Kigbafori D; Street, Leslie J; Chibale, Kelly