日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

通过表征 EGFRvIII 驱动的胶质母细胞瘤的适应性激酶组重编程,识别和利用组合合成致死性

Lin, Benjamin; Shelton, Abigail K; Smithberger, Erin; Ziebro, Julia; Skinner, Kasey R; Bash, Ryan E; Kirkman, Richard; Stamper, Allie; Butler, Madison; Flores, Alex; Angus, Steven P; East, Michael P; Cloughesy, Timothy F; Nathanson, David A; Berens, Michael E; Sarkaria, Jann N; Binder, Zev A; O'Rourke, Donald M; Howton, Timothy C; Lasseigne, Brittany N; Willey, Christopher D; Johnson, Gary L; Hjelmeland, Anita B; Furnari, Frank B; Miller, C Ryan

MerTK as a therapeutic target in glioblastoma

MerTK作为胶质母细胞瘤的治疗靶点

Wu, Jing; Frady, Lauren N; Bash, Ryan E; Cohen, Stephanie M; Schorzman, Allison N; Su, Yu-Ting; Irvin, David M; Zamboni, William C; Wang, Xiaodong; Frye, Stephen V; Ewend, Matthew G; Sulman, Erik P; Gilbert, Mark R; Earp, H Shelton; Miller, C Ryan

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

在胶质母细胞瘤的临床前模型中,强效PI3K和MAPK抑制剂的联合疗法可克服对单一药物的适应性激酶组耐药性。

McNeill, Robert S; Canoutas, Demitra A; Stuhlmiller, Timothy J; Dhruv, Harshil D; Irvin, David M; Bash, Ryan E; Angus, Steven P; Herring, Laura E; Simon, Jeremy M; Skinner, Kasey R; Limas, Juanita C; Chen, Xin; Schmid, Ralf S; Siegel, Marni B; Van Swearingen, Amanda E D; Hadler, Michael J; Sulman, Erik P; Sarkaria, Jann N; Anders, Carey K; Graves, Lee M; Berens, Michael E; Johnson, Gary L; Miller, C Ryan

Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.

MEK1/2 和 PI3K 或 PDGFR 的联合激酶抑制剂对颅内三阴性乳腺癌有效

Van Swearingen Amanda E D, Sambade Maria J, Siegel Marni B, Sud Shivani, McNeill Robert S, Bevill Samantha M, Chen Xin, Bash Ryan E, Mounsey Louisa, Golitz Brian T, Santos Charlene, Deal Allison, Parker Joel S, Rashid Naim, Miller C Ryan, Johnson Gary L, Anders Carey K

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

核心通路突变诱导小鼠星形胶质细胞去分化为胶质母细胞瘤干细胞,这些干细胞对辐射敏感但对替莫唑胺耐药。

Schmid, Ralf S; Simon, Jeremy M; Vitucci, Mark; McNeill, Robert S; Bash, Ryan E; Werneke, Andrea M; Huey, Lauren; White, Kristen K; Ewend, Matthew G; Wu, Jing; Miller, C Ryan

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

在小鼠胶质瘤切除和复发模型中,反应性星形胶质细胞增强肿瘤侵袭性

Okolie, Onyinyechukwu; Bago, Juli R; Schmid, Ralf S; Irvin, David M; Bash, Ryan E; Miller, C Ryan; Hingtgen, Shawn D