日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity

TLR7和TLR9中不同的TIR信号域对系统性自身免疫产生相反的作用

Leibler, Claire; Thomas, Kayla B; Josensi, Coralie; Levack, Russell C; Smita, Shuchi; John, Shinu; Wikenheiser, Daniel J; Bastacky, Sheldon; Gingras, Sebastien; Nickerson, Kevin M; Shlomchik, Mark J

Purine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis

嘌呤核苷磷酸化酶抑制是治疗化学性出血性膀胱炎的有效方法

Amanda Wolf-Johnston, Youko Ikeda, Irina Zabbarova, Anthony J Kanai, Sheldon Bastacky, Robert Moldwin, Joel Nh Stern, Edwin K Jackson, Lori A Birder

NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7

B细胞和巨噬细胞中的NADPH氧化酶通过调节TLR7来抵抗小鼠狼疮。

Gordon, Rachael A; Cosgrove, Haylee A; Marinov, Anthony; Gingras, Sebastien; Tilstra, Jeremy S; Campbell, Allison M; Bastacky, Sheldon I; Kashgarian, Michael; Perl, Andras; Nickerson, Kevin M; Shlomchik, Mark J

Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/ lpr lupus-prone mice

在CD4+ T细胞中诱导性敲除Ezh2可抑制肾脏T细胞浸润,并预防MRL/lpr狼疮易感小鼠的间质性肾炎。

Xiaoqing Zheng ,Mikhail G Dozmorov ,Luis Espinoza ,Mckenna M Bowes ,Sheldon Bastacky ,Amr H Sawalha

Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell infiltration and prevents interstitial nephritis in MRL/lpr lupus-prone mice

CD4+ T 细胞中 Ezh2 的诱导缺失可抑制肾脏 T 细胞浸润并预防 MRL/lpr 狼疮易感小鼠的间质性肾炎

Xiaoqing Zheng, Mikhail G Dozmorov, Luis Espinoza, Mckenna M Bowes, Sheldon Bastacky, Amr H Sawalha

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

与年龄相关的 B 细胞是小鼠自身免疫的异质性和动态驱动因素

Kevin M Nickerson, Shuchi Smita, Kenneth B Hoehn, Anthony D Marinov, Kayla B Thomas, Justin T Kos, Yi Yang, Sheldon I Bastacky, Corey T Watson, Steven H Kleinstein, Mark J Shlomchik

Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice

B细胞中Ezh2基因敲除会损害浆细胞分化并改善MRL/lpr小鼠的狼疮样疾病

Zheng, Xiaoqing; Dozmorov, Mikhail G; Strohlein, Colleen E; Bastacky, Sheldon; Sawalha, Amr H

B cell-intrinsic Myd88 regulates disease progression in murine lupus

B细胞内在的Myd88调控小鼠狼疮的疾病进展

Tilstra, Jeremy S; Kim, Minjung; Gordon, Rachael A; Leibler, Claire; Cosgrove, Haylee A; Bastacky, Sheldon; Nickerson, Kevin M; Shlomchik, Mark J

B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice

细胞内在 TLR7 表达导致 TLR9 缺陷小鼠患上严重狼疮

Haylee A Cosgrove, Sebastien Gingras, Minjung Kim, Sheldon Bastacky, Jeremy S Tilstra, Mark J Shlomchik

Calponin 2 regulates ketogenesis to mitigate acute kidney injury

钙调蛋白2通过调节酮体生成来减轻急性肾损伤

Gui, Yuan; Palanza, Zachary; Gupta, Priya; Li, Hanwen; Pan, Yuchen; Wang, Yuanyuan; Hargis, Geneva; Kreutzer, Donald L; Wang, Yanlin; Bastacky, Sheldon I; Liu, Yansheng; Liu, Silvia; Zhou, Dong