日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models

靶向外显子1的miRNA可降低亨廷顿病模型中致病性外显子1 HTT蛋白的表达。

Sogorb-Gonzalez, Marina; Landles, Christian; Caron, Nicholas S; Stam, Anouk; Osborne, Georgina; Hayden, Michael R; Howland, David; van Deventer, Sander; Bates, Gillian P; Vallès, Astrid; Evers, Melvin

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

更正:亨廷顿蛋白HTT1a在人体组织中的生成方式取决于CAG重复序列的长度。

Hoschek, Franziska; Natan, Julia; Wagner, Maximilian; Sathasivam, Kirupa; Abdelmoez, Alshaimaa; Einem, Björn von; Bates, Gillian P; Landwehrmeyer, G Bernhard; Neueder, Andreas

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays

突变型亨廷顿蛋白随CAG重复序列扩增而减少:对治疗和生物测定的启示

Landles, Christian; Osborne, Georgina F; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M; Ali, Nadira; Bobkov, Konstantin; Greene, Jonathan R; Sathasivam, Kirupa; Bates, Gillian P

Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease.

可用于亨廷顿病小鼠模型的可转化血浆和脑脊液生物标志物

Bondulich Marie K, Phillips Jemima, Cañibano-Pico María, Nita Iulia M, Byrne Lauren M, Wild Edward J, Bates Gillian P

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

在三种技术平台上开发用于检测可溶性和聚集性亨廷顿蛋白的新型生物测定方法

Landles, Christian; Milton, Rebecca E; Jean, Alexandre; McLarnon, Stuart; McAteer, Sean J; Taxy, Bridget A; Osborne, Georgina F; Zhang, Chuangchuang; Duan, Wenzhen; Howland, David; Bates, Gillian P

Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.

更正:SIRT2 消融对脑内微管蛋白乙酰化、胆固醇生物合成或亨廷顿病表型的进展没有影响

Bobrowska Anna, Donmez Gizem, Weiss Andreas, Guarente Leonard, Bates Gillian

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay

利用 QuantiGene 多重检测法对 zQ175 HD 小鼠模型脑区中 Htt 转录本进行广泛的表达分析

Papadopoulou, Aikaterini S; Gomez-Paredes, Casandra; Mason, Michael A; Taxy, Bridget A; Howland, David; Bates, Gillian P

Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.

基因删除 S6k1 并不能挽救亨廷顿病 R6/2 小鼠模型中观察到的表型缺陷

Irvine Elaine E, Katsouri Loukia, Plattner Florian, Al-Qassab Hind, Al-Nackkash Rand, Bates Gillian P, Withers Dominic J

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

亨廷顿病基因敲入小鼠的表型出现与突变亨廷顿基因的不完全剪接有关

Franich Nicholas R, Hickey Miriam A, Zhu Chunni, Osborne Georgina F, Ali Nadira, Chu Tiffany, Bove Nicholas H, Lemesre Vincent, Lerner Renata P, Zeitlin Scott O, Howland David, Neueder Andreas, Landles Christian, Bates Gillian P, Chesselet Marie-Francoise