日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays

突变型亨廷顿蛋白随CAG重复序列扩增而减少:对治疗和生物测定的启示

Landles, Christian; Osborne, Georgina F; Phillips, Jemima; Canibano-Pico, Maria; Nita, Iulia M; Ali, Nadira; Bobkov, Konstantin; Greene, Jonathan R; Sathasivam, Kirupa; Bates, Gillian P

Translatable plasma and CSF biomarkers for use in mouse models of Huntington's disease.

可用于亨廷顿病小鼠模型的可转化血浆和脑脊液生物标志物

Bondulich Marie K, Phillips Jemima, Cañibano-Pico María, Nita Iulia M, Byrne Lauren M, Wild Edward J, Bates Gillian P

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

在三种技术平台上开发用于检测可溶性和聚集性亨廷顿蛋白的新型生物测定方法

Landles, Christian; Milton, Rebecca E; Jean, Alexandre; McLarnon, Stuart; McAteer, Sean J; Taxy, Bridget A; Osborne, Georgina F; Zhang, Chuangchuang; Duan, Wenzhen; Howland, David; Bates, Gillian P

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay

利用 QuantiGene 多重检测法对 zQ175 HD 小鼠模型脑区中 Htt 转录本进行广泛的表达分析

Papadopoulou, Aikaterini S; Gomez-Paredes, Casandra; Mason, Michael A; Taxy, Bridget A; Howland, David; Bates, Gillian P

Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.

基因删除 S6k1 并不能挽救亨廷顿病 R6/2 小鼠模型中观察到的表型缺陷

Irvine Elaine E, Katsouri Loukia, Plattner Florian, Al-Qassab Hind, Al-Nackkash Rand, Bates Gillian P, Withers Dominic J

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

亨廷顿病基因敲入小鼠的表型出现与突变亨廷顿基因的不完全剪接有关

Franich Nicholas R, Hickey Miriam A, Zhu Chunni, Osborne Georgina F, Ali Nadira, Chu Tiffany, Bove Nicholas H, Lemesre Vincent, Lerner Renata P, Zeitlin Scott O, Howland David, Neueder Andreas, Landles Christian, Bates Gillian P, Chesselet Marie-Francoise

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

HSF1依赖性和非依赖性哺乳动物体内热休克反应的调控及其在亨廷顿病小鼠模型中的受损

Neueder, Andreas; Gipson, Theresa A; Batterton, Sophie; Lazell, Hayley J; Farshim, Pamela P; Paganetti, Paolo; Housman, David E; Bates, Gillian P

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease

亨廷顿病小鼠模型中胚胎突变亨廷顿蛋白聚集体的形成

Osmand, Alexander P; Bichell, Terry Jo; Bowman, Aaron B; Bates, Gillian P

Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease

胃黏膜活检的特征分析揭示了亨廷顿病的改变

McCourt, Andrew C; O'Donovan, Kirsty L; Ekblad, Eva; Sand, Elin; Craufurd, David; Rosser, Anne; Sanders, David; Stoy, Nicholas; Rickards, Hugh; Wierup, Nils; Bates, Gillian P; Björkqvist, Maria; Quarrell, Oliver