日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological tools to modulate ordered membrane domains and order-dependent protein function

利用药理学工具调节有序膜结构域和有序依赖性蛋白质功能

Stefanski, Katherine M; Huang, Hui; Luu, Dustin D; Li, Geoffrey C; Hutchison, James M; Saksena, Nilabh; Fisch, Alexander J; Hasaka, Thomas P; Bauer, Joshua A; Kenworthy, Anne K; Van Horn, Wade D; Sanders, Charles R

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants

高通量筛选鉴定出一种与长QT综合征相关的KCNQ1变异体的转运校正因子

Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R

Protocol for high-throughput drug screening in 384-well 3D collagen cultures of SC colorectal cancer cells using colony morphology as a readout

利用集落形态作为读数指标,在384孔3D胶原培养的SC结直肠癌细胞中进行高通量药物筛选的方案

Harmych, Sarah J; Hasaka, Thomas P; Jones, Vivian Truong; Bauer, Joshua A; Singh, Bhuminder

Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions

通过对192个风险区域进行多祖先精细定位分析,完善乳腺癌遗传风险和生物学机制

Jia, Guochong; Chen, Zhishan; Ping, Jie; Cai, Qiuyin; Tao, Ran; Li, Chao; Bauer, Joshua A; Xie, Yuhan; Ambs, Stefan; Barnard, Mollie E; Chen, Yu; Choi, Ji-Yeob; Gao, Yu-Tang; Garcia-Closas, Montserrat; Gu, Jian; Hu, Jennifer J; Iwasaki, Motoki; John, Esther M; Kweon, Sun-Seog; Li, Christopher I; Matsuda, Koichi; Matsuo, Keitaro; Nathanson, Katherine L; Nemesure, Barbara; Olopade, Olufunmilayo I; Pal, Tuya; Park, Sue K; Park, Boyoung; Press, Michael F; Sanderson, Maureen; Sandler, Dale P; Shen, Chen-Yang; Troester, Melissa A; Yao, Song; Zheng, Ying; Ahearn, Thomas; Brewster, Abenaa M; Falusi, Adeyinka; Hennis, Anselm J M; Ito, Hidemi; Kubo, Michiaki; Lee, Eun-Sook; Makumbi, Timothy; Ndom, Paul; Noh, Dong-Young; O'Brien, Katie M; Ojengbede, Oladosu; Olshan, Andrew F; Park, Min-Ho; Reid, Sonya; Yamaji, Taiki; Zirpoli, Gary; Butler, Ebonee N; Huang, Maosheng; Low, Siew-Kee; Obafunwa, John; Weinberg, Clarice R; Zhang, Haoyu; Zhao, Hongyu; Cote, Michelle L; Ambrosone, Christine B; Huo, Dezheng; Li, Bingshan; Kang, Daehee; Palmer, Julie R; Shu, Xiao-Ou; Haiman, Christopher A; Guo, Xingyi; Long, Jirong; Zheng, Wei

3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer.

3D胶原蛋白高通量筛选可识别诱导上皮极性并增强结直肠癌化疗反应的药物

Harmych Sarah J, Hasaka Thomas P, Sievers Chelsie K, Kang Seung Woo, Ramirez Marisol A, Jones Vivian Truong, Zhao Zhiguo, Kovtun Oleg, Wahoski Claudia C, Liu Qi, Lau Ken S, Coffey Robert J, Bauer Joshua A, Singh Bhuminder

Multi-Ancestry Transcriptome-wide Association Studies Uncover New Insights into Breast Cancer Genetics and Biology

多种族转录组关联研究揭示乳腺癌遗传学和生物学的新见解

Ping, Jie; Jia, Guochong; Cai, Qiuyin; Guo, Xingyi; Wang, Jifeng; Tao, Ran; Li, Bingshan; Bauer, Joshua A; Xie, Yuhan; Ambs, Stefan; Barnard, Mollie E; Chen, Yu; Choi, Ji-Yeob; Gao, Yu-Tang; Garcia-Closas, Montserrat; Gu, Jian; Hu, Jennifer J; Iwasaki, Motoki; John, Esther M; Kweon, Sun-Seog; Li, Christopher I; Matsuda, Koichi; Matsuo, Keitaro; Nathanson, Katherine L; Nemesure, Barbara; Olopade, Olufunmilayo I; Pal, Tuya; Park, Sue K; Park, Boyoung; Press, Michael F; Sanderson, Maureen; Sandler, Dale P; Yao, Song; Zheng, Ying; Ahearn, Thomas; Brewster, Abenaa M; Falusi, Adeyinka; Hennis, Anselm J M; Ito, Hidemi; Kubo, Michiaki; Lee, Eun-Sook; Makumbi, Timothy; Mapoko, Berthe S E; Noh, Dong-Young; O'Brien, Katie M; Ojengbede, Oladosu; Olshan, Andrew F; Park, Min-Ho; Reid, Sonya; Yamaji, Taiki; Zirpoli, Gary; Butler, Ebonee N; Huang, Maosheng; Low, Siew-Kee; Obafunwa, John; Weinberg, Clarice R; Zhang, Haoyu; Zhao, Hongyu; Ambrosone, Christine B; Cote, Michelle L; Huo, Dezheng; Haiman, Christopher A; Kang, Daehee; Palmer, Julie R; Troester, Melissa A; Shu, Xiao-Ou; Long, Jirong; Zheng, Wei

High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

高通量筛选鉴定出一种针对长QT综合征相关KCNQ1变异的小分子转运校正剂

Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R

Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function

利用药理学工具调节有序膜结构域和有序依赖性蛋白质功能

Stefanski, Katherine M; Huang, Hui; Luu, Dustin D; Hutchison, James M; Saksena, Nilabh; Fisch, Alexander J; Hasaka, Thomas P; Bauer, Joshua A; Kenworthy, Anne K; Van Horn, Wade D; Sanders, Charles R

Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K(ATP) Channels

VU0542270 的发现与表征:首个血管 Kir6.1/SUR2B K(ATP) 通道选择性抑制剂

Li, Kangjun; McClenahan, Samantha J; Han, Changho; Bungard, Joseph D; Rathnayake, Upendra; Boutaud, Olivier; Bauer, Joshua A; Days, Emily L; Lindsley, Craig W; Shelton, Elaine L; Denton, Jerod S

Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

通过高通量筛选鉴定出一种新型 Kir6.2/SUR1 通道开放剂骨架,并对其合成和构效关系进行了研究。

Dodd, Cayden J; Chronister, Keagan S; Rathnayake, Upendra; Parr, Lauren C; Li, Kangjun; Chang, Sichen; Mi, Dehui; Days, Emily L; Bauer, Joshua A; Cho, Hyekyung P; Boutaud, Olivier; Denton, Jerod S; Lindsley, Craig W; Han, Changho