Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux
联合使用靶向LtrMDR1不同结构域的亚最佳剂量抑制剂,可通过抑制药物外排,有效克服利什曼原虫对米替福新产生的耐药性。
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00423-06
Pérez-Victoria, José M; Cortés-Selva, Fernando; Parodi-Talice, Adriana; Bavchvarov, Boris I; Pérez-Victoria, F Javier; Muñoz-Martínez, Francisco; Maitrejean, Mathias; Costi, M Paola; Barron, Denis; Di Pietro, Attilio; Castanys, Santiago; Gamarro, Francisco