Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model
单核RNA测序揭示了绵羊亨廷顿病模型中,中型棘状神经元在神经元死亡发生之前存在谷氨酸兴奋性毒性特征。
期刊:Human Molecular Genetics
影响因子:3.2
doi:10.1093/hmg/ddae087
Jiang, Andrew; You, Linya; Handley, Renee R; Hawkins, Victoria; Reid, Suzanne J; Jacobsen, Jessie C; Patassini, Stefano; Rudiger, Skye R; Mclaughlan, Clive J; Kelly, Jennifer M; Verma, Paul J; Bawden, C Simon; Gusella, James F; MacDonald, Marcy E; Waldvogel, Henry J; Faull, Richard L M; Lehnert, Klaus; Snell, Russell G