日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis

α-珠蛋白和Nprl3的古老基因组联系将代谢与红细胞生成联系起来

Alexandra E Preston ,Joe N Frost ,Megan R Teh ,Mohsin Badat ,Andrew E Armitage ,Ruggiero Norfo ,Sarah K Wideman ,Muhammad Hanifi ,Natasha White ,Noémi Ba Roy ,Christian Babbs ,Bart Ghesquiere ,James Davies ,Andrew Jm Howden ,Linda V Sinclair ,Jim R Hughes ,Mira Kassouf ,Rob Beagrie ,Douglas R Higgs ,Hal Drakesmith

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C

Multiplex-GAM:全基因组染色质接触识别提供了 Hi-C 所忽视的见解

Robert A Beagrie #, Christoph J Thieme #, Carlo Annunziatella #, Catherine Baugher, Yingnan Zhang, Markus Schueler, Alexander Kukalev, Rieke Kempfer, Andrea M Chiariello, Simona Bianco, Yichao Li, Trenton Davis, Antonio Scialdone, Lonnie R Welch, Mario Nicodemi, Ana Pombo

Gene silencing dynamics are modulated by transiently active regulatory elements

基因沉默动态受瞬时激活的调控元件调控。

Marit W Vermunt ,Jing Luan ,Zhe Zhang ,A Josephine Thrasher ,Anran Huang ,Megan S Saari ,Eugene Khandros ,Robert A Beagrie ,Shiping Zhang ,Pranay Vemulamada ,Matilda Brilleman ,Kiwon Lee ,Jennifer A Yano ,Belinda M Giardine ,Cheryl A Keller ,Ross C Hardison ,Gerd A Blobel

Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks

致病性人类变异体使GATA2锌指结构域移位,从而破坏造血基因表达和信号传导网络。

Jung, Mabel Minji; Shen, Siqi; Botten, Giovanni A; Olender, Thomas; Katsumura, Koichi R; Johnson, Kirby D; Soukup, Alexandra A; Liu, Peng; Zhang, Qingzhou; Jensvold, Zena D; Lewis, Peter W; Beagrie, Robert A; Low, Jason Kk; Yang, Lihua; Mackay, Joel P; Godley, Lucy A; Brand, Marjorie; Xu, Jian; Keles, Sunduz; Bresnick, Emery H

Ancient genomic linkage couples metabolism with erythroid development

古老的基因组连锁将代谢与红细胞发育联系起来

Alexandra E Preston, Joe N Frost, Mohsin Badat, Megan Teh, Andrew E Armitage, Ruggiero Norfo, Sarah K Wideman, Muhammad Hanifi, Natasha White, Noémi Roy, Bart Ghesquiere, Christian Babbs, Mira Kassouf, James Davies, Jim R Hughes, Rob Beagrie, Douglas R Higgs, Hal Drakesmith

Scalable in vitro production of defined mouse erythroblasts

可规模化体外生产特定小鼠成红细胞

Francis, Helena S; Harold, Caroline L; Beagrie, Robert A; King, Andrew J; Gosden, Matthew E; Blayney, Joseph W; Jeziorska, Danuta M; Babbs, Christian; Higgs, Douglas R; Kassouf, Mira T

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

全基因组范围内对顺式调控元件组织进行高分辨率靶向3C分析

Damien J Downes ,Robert A Beagrie ,Matthew E Gosden ,Jelena Telenius ,Stephanie J Carpenter ,Lea Nussbaum ,Sara De Ornellas ,Martin Sergeant ,Chris Q Eijsbouts ,Ron Schwessinger ,Jon Kerry ,Nigel Roberts ,Arun Shivalingam ,Afaf El-Sagheer ,A Marieke Oudelaar ,Tom Brown ,Veronica J Buckle ,James O J Davies ,Jim R Hughes

Reactivation of a developmentally silenced embryonic globin gene

重新激活发育过程中沉默的胚胎珠蛋白基因

Andrew J King #, Duantida Songdej #, Damien J Downes, Robert A Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C Suciu, A Marieke Oudelaar, Lars L P Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A Sharpe, Jacqueline

Enhancers predominantly regulate gene expression during differentiation via transcription initiation

增强子主要通过转录起始来调节分化过程中的基因表达

Martin S C Larke, Ron Schwessinger, Takayuki Nojima, Jelena Telenius, Robert A Beagrie, Damien J Downes, A Marieke Oudelaar, Julia Truch, Bryony Graham, M A Bender, Nicholas J Proudfoot, Douglas R Higgs, Jim R Hughes

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities

先天性红细胞生成障碍性贫血 I 型 (CDA-I) 红细胞生成过程的重现可识别分化缺陷和核仁异常

Scott, Caroline; Downes, Damien J; Brown, Jill M; Beagrie, Robert; Olijnik, Aude-Anais; Gosden, Matthew; Schwessinger, Ron; Fisher, Christopher A; Rose, Anna; Ferguson, David J P; Johnson, Errin; Hill, Quentin A; Okoli, Steven; Renella, Raffaele; Ryan, Kate; Brand, Marjorie; Hughes, Jim; Roy, Noemi B A; Higgs, Douglas R; Babbs, Christian; Buckle, Veronica J