日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

脑能量拯救:一种针对衰老相关神经退行性疾病的新兴治疗理念

Cunnane, Stephen C; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B; Beal, M Flint; Bergersen, Linda H; Brinton, Roberta D; de la Monte, Suzanne; Eckert, Anne; Harvey, Jenni; Jeggo, Ross; Jhamandas, Jack H; Kann, Oliver; la Cour, Clothide Mannoury; Martin, William F; Mithieux, Gilles; Moreira, Paula I; Murphy, Michael P; Nave, Klaus-Armin; Nuriel, Tal; Oliet, Stéphane H R; Saudou, Frédéric; Mattson, Mark P; Swerdlow, Russell H; Millan, Mark J

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

神经退行性疾病中线粒体酶α-酮戊二酸脱氢酶复合物的减少——是有益还是有害?

Chen, Huanlian; Denton, Travis T; Xu, Hui; Calingasan, Noel; Beal, M Flint; Gibson, Gary E

Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo

优先激活PPAR-α可减轻神经炎症,并阻断体内神经退行性变。

Esmaeili, Mohammad A; Yadav, Shilpi; Gupta, Ravi Kr; Waggoner, Garrett R; Deloach, Abigail; Calingasan, Noel Y; Beal, M Flint; Kiaei, Mahmoud

Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial

肌苷可增加帕金森病患者血清和脑脊液尿酸水平:一项随机临床试验

Schwarzschild, Michael A; Ascherio, Alberto; Beal, M Flint; Cudkowicz, Merit E; Curhan, Gary C; Hare, Joshua M; Hooper, D Craig; Kieburtz, Karl D; Macklin, Eric A; Oakes, David; Rudolph, Alice; Shoulson, Ira; Tennis, Marsha K; Espay, Alberto J; Gartner, Maureen; Hung, Albert; Bwala, Grace; Lenehan, Richard; Encarnacion, Elmyra; Ainslie, Melissa; Castillo, Richard; Togasaki, Daniel; Barles, Gina; Friedman, Joseph H; Niles, Lisa; Carter, Julie H; Murray, Megan; Goetz, Christopher G; Jaglin, Jeana; Ahmed, Anwar; Russell, David S; Cotto, Candace; Goudreau, John L; Russell, Doozie; Parashos, Sotirios Andreas; Ede, Patricia; Saint-Hilaire, Marie H; Thomas, Cathi-Ann; James, Raymond; Stacy, Mark A; Johnson, Julia; Gauger, Lisa; Antonelle de Marcaida, J; Thurlow, Sheila; Isaacson, Stuart H; Carvajal, Lisbeth; Rao, Jayaraman; Cook, Maureen; Hope-Porche, Charlise; McClurg, Lauren; Grasso, Daniela L; Logan, Robert; Orme, Constance; Ross, Tori; Brocht, Alicia F D; Constantinescu, Radu; Sharma, Saloni; Venuto, Charles; Weber, Joseph; Eaton, Ken

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

PGC-1α 过表达会加剧阿尔茨海默病转基因小鼠模型中β-淀粉样蛋白和tau蛋白的沉积

Dumont, Magali; Stack, Cliona; Elipenahli, Ceyhan; Jainuddin, Shari; Launay, Nathalie; Gerges, Meri; Starkova, Natalia; Starkov, Anatoly A; Calingasan, Noel Y; Tampellini, Davide; Pujol, Aurora; Beal, M Flint

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy.

吡格列酮可阻止 X 连锁肾上腺脑白质营养不良小鼠模型中的轴突变性

Morató Laia, Galino Jorge, Ruiz Montserrat, Calingasan Noel Ylagan, Starkov Anatoly A, Dumont Magali, Naudí Alba, Martínez Juan José, Aubourg Patrick, Portero-Otín Manuel, Pamplona Reinald, Galea Elena, Beal M Flint, Ferrer Isidre, Fourcade Stéphane, Pujol Aurora

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease

利用高效合成三萜类化合物靶向Nrf2介导的基因转录,可减轻MPTP诱导的帕金森病小鼠模型中的多巴胺能神经毒性。

Kaidery, Navneet Ammal; Banerjee, Rebecca; Yang, Lichuan; Smirnova, Natalya A; Hushpulian, Dmitry M; Liby, Karen T; Williams, Charlotte R; Yamamoto, Masayuki; Kensler, Thomas W; Ratan, Rajiv R; Sporn, Michael B; Beal, M Flint; Gazaryan, Irina G; Thomas, Bobby

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

线粒体复合物II缺陷在表达突变亨廷顿蛋白N端片段的亨廷顿病遗传模型中的作用

Damiano, Maria; Diguet, Elsa; Malgorn, Carole; D'Aurelio, Marilena; Galvan, Laurie; Petit, Fanny; Benhaim, Lucile; Guillermier, Martine; Houitte, Diane; Dufour, Noelle; Hantraye, Philippe; Canals, Josep M; Alberch, Jordi; Delzescaux, Thierry; Déglon, Nicole; Beal, M Flint; Brouillet, Emmanuel

Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease

早期帕金森病和偶发性路易体病中的体细胞线粒体DNA突变

Lin, Michael T; Cantuti-Castelvetri, Ippolita; Zheng, Kangni; Jackson, Katie E; Tan, Yong B; Arzberger, Thomas; Lees, Andrew J; Betensky, Rebecca A; Beal, M Flint; Simon, David K

Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease

线粒体通透性转换孔组分环孢菌素D可区分MPTP诱导的帕金森病小鼠模型中的黑质纹状体多巴胺能神经元死亡模式。

Thomas, Bobby; Banerjee, Rebecca; Starkova, Natalia N; Zhang, Steven F; Calingasan, Noel Y; Yang, Lichuan; Wille, Elizabeth; Lorenzo, Beverly J; Ho, Daniel J; Beal, M Flint; Starkov, Anatoly