Beat Bornhauser相关文献与解析，生知库 | 链接生命科学的每一步

Juliane Mietz,Lukas Egli,Meike Misiune,Arianna Picozzi,Nicolò Coianiz,Danielle Thompson,Marianna Ponzo,Alisson Charmey,Beat Bornhauser,Chiara F Magnani,Christian Münz,Obinna Chijioke

细胞生物学

毒理研究

FAS

发表日期：2026

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A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia

三维体外模型重现了儿童急性淋巴细胞白血病的体内特征和耐药表型

期刊:Leukemia

影响因子:12.8

doi:10.1038/s41375-025-02739-8

Magdalini Kanari ，Iria Jimenez Garcia ，Fabio D Steffen ，Lisa A Krattiger ，Charles Bataclan ，Wangjie Liu ，Benjamin R Simona ，Bart Deplancke ，Olaia Naveiras ，Martin Ehrbar ，Beat Bornhauser ，Jean-Pierre Bourquin

白血病

发表日期：2025

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Functional analysis of structural variants in single cells using Strand-seq

利用链测序技术对单细胞中的结构变异进行功能分析

期刊:Nature Biotechnology

影响因子:33.1

doi:10.1038/s41587-022-01551-4

Hyobin Jeong # ，Karen Grimes # ，Kerstin K Rauwolf ，Peter-Martin Bruch ，Tobias Rausch ，Patrick Hasenfeld ，Eva Benito ，Tobias Roider ，Radhakrishnan Sabarinathan ，David Porubsky ，Sophie A Herbst ，Büşra Erarslan-Uysal ，Johann-Christoph Jann ，Tobias Marschall ，Daniel Nowak ，Jean-Pierre Bourquin ，Andreas E Kulozik ，Sascha Dietrich ，Beat Bornhauser ，Ashley D Sanders ，Jan O Korbel

Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia

用于识别原发性白血病对前药治疗反应的微生理药物测试平台

期刊:Advanced Healthcare Materials

影响因子:10

doi:10.1002/adhm.202202506

Furkan Gökçe ，Alicia Kaestli ，Christian Lohasz ，Martina de Geus ，Hans-Michael Kaltenbach ，Kasper Renggli ，Beat Bornhauser ，Andreas Hierlemann ，Mario Modena

白血病

发表日期：2023

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B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow

B细胞和T细胞急性淋巴细胞白血病在骨髓的不同部位逃避化疗。

期刊:Haematologica

影响因子:8.2

doi:10.3324/haematol.2021.280451

Malwine J Barz，Lena Behrmann，Danaëlle Capron，Gabriele Zuchtriegel，Fabio D Steffen，Leo Kunz，Yang Zhang，Iria Jimenez Vermeerbergen，Blerim Marovca，Moritz Kirschmann，Antonia Zech，César Nombela-Arrieta，Urs Ziegler，Timm Schroeder，Beat Bornhauser，Jean-Pierre Bourquin

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

MSC.sensor：捕捉癌细胞与基质的相互作用以进行功能分析

期刊:SLAS Discovery

影响因子:2.7

doi:10.1016/j.slasd.2023.08.003

Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin

Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

GSK3α 的超分子组装作为细胞对氨基酸饥饿的反应

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2022.05.025

Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Lorent Loxha, Buesra Cinar, Evgeni Ponimaskin, James Degar, Connor McGuckin, Gabriela Chiosis, Cornelia Eckert, Gunnar Cario, Beat Bornhauser, Jean-Pierre Bourquin, Martin Stanulla, Alejandro Gutierrez

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis

维奈托克通过增强肿瘤细胞吞噬作用来提高治疗性抗体在B细胞恶性肿瘤中的疗效。

期刊:Blood Advances

影响因子:7.4

doi:10.1182/bloodadvances.2022007364

Fotini Vogiatzi ，Julia Heymann ，Kristina Müller ，Dorothee Winterberg ，Aneta Drakul ，Thies Rösner ，Lennart Lenk ，Michelle Heib ，Carina Lynn Gehlert ，Gunnar Cario ，Martin Schrappe ，Alexander Claviez ，Beat Bornhauser ，Jean-Pierre Bourquin ，Simon Bomken ，Dieter Adam ，Fabian-Simon Frielitz ，Britta Maecker-Kolhoff ，Martin Stanulla ，Thomas Valerius ，Matthias Peipp ，Christian Kellner ，Denis M Schewe

LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

LRH-1/NR5A2与糖皮质激素受体相互作用，从而调节糖皮质激素抵抗。

期刊:EMBO Reports

影响因子:6.5

doi:10.15252/embr.202154195

Svenja Michalek ，Thomas Goj ，Anna Pia Plazzo ，Blerim Marovca ，Beat Bornhauser ，Thomas Brunner

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

BTK 抑制剂通过抑制氨基酸反应途径使急性淋巴细胞白血病对天冬酰胺酶敏感

期刊:Blood

影响因子:21

doi:10.1182/blood.2021011787

Miriam Butler, Dorette S van Ingen Schenau, Jiangyan Yu, Silvia Jenni, Maria P Dobay, Rico Hagelaar, Britt M T Vervoort, Trisha M Tee, Fieke W Hoff, Jules P Meijerink, Steven M Kornblau, Beat Bornhauser, Jean-Pierre Bourquin, Roland P Kuiper, Laurens T van der Meer, Frank N van Leeuwen

Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells

NKG2A 和 FAS 的共编辑可增强 CAR NK 细胞的长期细胞毒性和持久性。

A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia

三维体外模型重现了儿童急性淋巴细胞白血病的体内特征和耐药表型

Functional analysis of structural variants in single cells using Strand-seq

利用链测序技术对单细胞中的结构变异进行功能分析

Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia

用于识别原发性白血病对前药治疗反应的微生理药物测试平台

B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow

B细胞和T细胞急性淋巴细胞白血病在骨髓的不同部位逃避化疗。

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling

MSC.sensor：捕捉癌细胞与基质的相互作用以进行功能分析

Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

GSK3α 的超分子组装作为细胞对氨基酸饥饿的反应

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis

维奈托克通过增强肿瘤细胞吞噬作用来提高治疗性抗体在B细胞恶性肿瘤中的疗效。

LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

LRH-1/NR5A2与糖皮质激素受体相互作用，从而调节糖皮质激素抵抗。

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

BTK 抑制剂通过抑制氨基酸反应途径使急性淋巴细胞白血病对天冬酰胺酶敏感