日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Caspase-2 kills cells with extra centrosomes

Caspase-2 可杀死具有额外中心体的细胞

Dario Rizzotto ,Vincenza Vigorito ,Patricia Rieder ,Filip Gallob ,Gian Mario Moretta ,Claudia Soratroi ,Joel S Riley ,Florian Bellutti ,Stefano Li Veli ,Alessia Mattivi ,Michael Lohmüller ,Sebastian Herzog ,Beat C Bornhauser ,Etienne D Jacotot ,Andreas Villunger ,Luca L Fava

TNFR2 is required for RIP1-dependent cell death in human leukemia

TNFR2 是人类白血病中 RIP1 依赖性细胞死亡所必需的

Júlia Aguadé-Gorgorió, Scott McComb, Cornelia Eckert, Anna Guinot, Blerim Marovca, Caterina Mezzatesta, Silvia Jenni, Liridon Abduli, Martin Schrappe, Maria Pamela Dobay, Martin Stanulla, Arend von Stackelberg, Gunnar Cario, Jean-Pierre Bourquin, Beat C Bornhauser

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

有效的细胞凋亡需要效应子 caspase-3 或 -7 对上游的细胞凋亡信号进行反馈放大

Scott McComb, Pik Ki Chan, Anna Guinot, Holmfridur Hartmannsdottir, Silvia Jenni, Maria Pamela Dobay, Jean-Pierre Bourquin, Beat C Bornhauser

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

TLX1 和 STAT5 协同增强子激活促进 NUP214-ABL1/TLX1 阳性 T 细胞急性淋巴细胞白血病的发展

Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, Jolien De Bie, Simon Bornschein, Nicole Mentens, Roel Vandepoel, Ellen Geerdens, Enrico Radaelli, Beat C Bornhauser, Andreas E Kulozik, Jules P Meijerink, Jean-Pierre Bourquin, Charles E de Bock, Jan Cools

Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

利用多色慢病毒CRISPR-Cas9技术高效构建多基因敲除细胞系和患者来源的异种移植瘤

Lena Behrmann ,Scott McComb ,Júlia Aguadé-Gorgorió ,Yun Huang ,Mario Hermann ,Pawel Pelczar ,Adriano Aguzzi ,Jean-Pierre Bourquin ,Beat C Bornhauser

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

SMAC 类似物激活并发细胞凋亡和坏死性凋亡用于治疗难治性和复发性 ALL

Scott McComb, Júlia Aguadé-Gorgorió, Lena Harder, Blerim Marovca, Gunnar Cario, Cornelia Eckert, Martin Schrappe, Martin Stanulla, Arend von Stackelberg, Jean-Pierre Bourquin, Beat C Bornhauser

Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases

EB 病毒感染 B 细胞引起的早期基因表达变化表明 CDK 和 survivin 是移植后淋巴增生性疾病的治疗靶点

Michele Bernasconi, Seigo Ueda, Patricia Krukowski, Beat C Bornhauser, Kristin Ladell, Marcus Dorner, Juerg A Sigrist, Cristina Campidelli, Roberta Aslandogmus, Davide Alessi, Christoph Berger, Stefano A Pileri, Roberto F Speck, David Nadal

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)

成纤维细胞生长因子 21 (FGF21) 通过 E3-泛素连接酶 Mylip/Idol 和 Canopy2 (Cnpy2)/Mylip 相互作用的 saposin 样蛋白 (Msap) 调节细胞中的低密度脂蛋白受体 (LDLR) 水平

Hai Thi Do, Timofey V Tselykh, Johanna Mäkelä, Tho Huu Ho, Vesa M Olkkonen, Beat C Bornhauser, Laura Korhonen, Noam Zelcer, Dan Lindholm

CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres

CD133 阳性胚胎横纹肌肉瘤干细胞样细胞群在横纹球中富集

Dagmar Walter, Sampoorna Satheesha, Patrick Albrecht, Beat C Bornhauser, Valentina D'Alessandro, Susanne M Oesch, Hubert Rehrauer, Ivo Leuschner, Ewa Koscielniak, Carole Gengler, Holger Moch, Michele Bernasconi, Felix K Niggli, Beat W Schäfer; CWS Study Group