日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy

循环肿瘤 DNA 测序确定了对 EGFR 抗体和化疗具有获得性耐药性的结直肠癌中的遗传耐药性缺口

Franciele H Knebel, Louise J Barber, Alice Newey, Dimitrios Kleftogiannis, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Fabiana Bettoni, Maurício Fernando Silva Almeida Ribeiro, Leonardo da Fonseca, Frederico Costa, Fernanda Cunha Capareli, Paulo M Hoff, Jorge Sabbaga, Anamaria A Camargo, Mar

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

结直肠癌抗 EGFR 治疗期间治疗耐药性和免疫景观演变的基因组和转录组决定因素

Andrew Woolston, Khurum Khan, Georgia Spain, Louise J Barber, Beatrice Griffiths, Reyes Gonzalez-Exposito, Lisa Hornsteiner, Marco Punta, Yatish Patil, Alice Newey, Sonia Mansukhani, Matthew N Davies, Andrew Furness, Francesco Sclafani, Clare Peckitt, Mirta Jiménez, Kyriakos Kouvelakis, Romana Ranft

Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

结直肠癌类器官的免疫肽组学显示 HLA I 类新抗原分布稀疏,且干扰素或 MEK 抑制剂治疗不会导致新抗原增加

Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-St

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

CEA 表达的异质性和可塑性导致患者来源的结肠直肠癌类器官对 CEA 靶向双特异性免疫治疗抗体 cibisatamab (CEA-TCB) 产生耐药性

Reyes Gonzalez-Exposito, Maria Semiannikova, Beatrice Griffiths, Khurum Khan, Louise J Barber, Andrew Woolston, Georgia Spain, Katharina von Loga, Ben Challoner, Radhika Patel, Michael Ranes, Amanda Swain, Janet Thomas, Annette Bryant, Claire Saffery, Nicos Fotiadis, Sebastian Guettler, David Mansfi