日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The senescent synapse: A look at autophagy, calcium handling, and mitochondrial bioenergetics at the synapse in ageing and Parkinson's disease

衰老突触：衰老和帕金森病中突触的自噬、钙处理和线粒体生物能量学研究

期刊:Current Research in Physiology
影响因子:1.7
doi:10.1016/j.crphys.2025.100166
Mukhtar, Shahzabe; Kataria, Shikha; Cimaglia, Gloria; Beccano-Kelly, Dayne
帕金森
神经科学
线粒体
衰老
自噬
发表日期：2025
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Tau depletion in human neurons mitigates Aβ-driven toxicity

人类神经元中 Tau 的消耗可减轻 Aβ 引起的毒性

期刊:Molecular Psychiatry
影响因子:9.6
doi:10.1038/s41380-024-02463-2
Bryan Ng, Jane Vowles, Féodora Bertherat, Ajantha Abey, Peter Kilfeather, Dayne Beccano-Kelly, M Irina Stefana, Darragh P O'Brien, Nora Bengoa-Vergniory, Phillippa J Carling, John A Todd, Tara M Caffrey, Natalie Connor-Robson, Sally A Cowley, Richard Wade-Martins
神经
Human
发表日期：2024
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Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation

携带帕金森 GBA-N370S 突变的体外纹状体微电路模型的早期缺陷

期刊:Npj Parkinsons Disease
影响因子:6.7
doi:10.1038/s41531-024-00694-2
Quyen B Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M L Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
神经
帕金森
发表日期：2024
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Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons

钙失调与线粒体衰竭和电生理成熟度在帕金森病 iPSC-多巴胺神经元中汇聚

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2023.107044
Dayne A Beccano-Kelly, Marta Cherubini, Yassine Mousba, Kaitlyn M L Cramb, Stefania Giussani, Maria Claudia Caiazza, Pavandeep Rai, Siv Vingill, Nora Bengoa-Vergniory, Bryan Ng, Gabriele Corda, Abhirup Banerjee, Jane Vowles, Sally Cowley, Richard Wade-Martins
神经
帕金森
发表日期：2023
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From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2

从突触功能障碍到遗传性帕金森病中的神经保护策略：LRRK2 的启示

期刊:Frontiers in Cellular Neuroscience
影响因子:4
doi:10.3389/fncel.2020.00158
Mancini, Andrea; Mazzocchetti, Petra; Sciaccaluga, Miriam; Megaro, Alfredo; Bellingacci, Laura; Beccano-Kelly, Dayne A; Di Filippo, Massimiliano; Tozzi, Alessandro; Calabresi, Paolo
LRRK2
帕金森
神经科学
发表日期：2020
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Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease

Cav2.3通道在帕金森病模型中导致多巴胺能神经元丢失

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-019-12834-x
Benkert, Julia; Hess, Simon; Roy, Shoumik; Beccano-Kelly, Dayne; Wiederspohn, Nicole; Duda, Johanna; Simons, Carsten; Patil, Komal; Gaifullina, Aisylu; Mannal, Nadja; Dragicevic, Elena; Spaich, Desirée; Müller, Sonja; Nemeth, Julia; Hollmann, Helene; Deuter, Nora; Mousba, Yassine; Kubisch, Christian; Poetschke, Christina; Striessnig, Joerg; Pongs, Olaf; Schneider, Toni; Wade-Martins, Richard; Patel, Sandip; Parlato, Rosanna; Frank, Tobias; Kloppenburg, Peter; Liss, Birgit
帕金森
神经科学
发表日期：2019
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Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

在人类 iPSC 中应用 CRISPR/Cas9 编辑和数字液滴 PCR 来生成新的敲入报告基因系，从而可视化多巴胺能神经元

期刊:Stem Cell Research
影响因子:0.8
doi:10.1016/j.scr.2019.101656
Christa Überbacher, Julia Obergasteiger, Mattia Volta, Serena Venezia, Stefan Müller, Isabella Pesce, Sara Pizzi, Giulia Lamonaca, Anne Picard, Giada Cattelan, Giorgio Malpeli, Michele Zoli, Dayne Beccano-Kelly, Rowan Flynn, Richard Wade-Martins, Peter P Pramstaller, Andrew A Hicks, Sally A Cowley, 
神经
Human
发表日期：2019
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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

在 LRRK2 G2019S 基因敲入小鼠中，谷氨酸和多巴胺神经传递的初始升高随着年龄的增长而下降，探索行为也随之下降

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.28377
Mattia Volta #, Dayne A Beccano-Kelly #, Sarah A Paschall #, Stefano Cataldi #, Sarah E MacIsaac #, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer #, Austen J Milnerwood #
神经
发表日期：2017
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Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release

慢性和急性 LRRK2 沉默不会对行为产生长期影响，而野生型和突变型 LRRK2 过表达则会引起运动和认知障碍，并改变多巴胺释放的调节

期刊:Parkinsonism & Related Disorders
影响因子:3.1
doi:10.1016/j.parkreldis.2015.07.025
Mattia Volta, Stefano Cataldi, Dayne Beccano-Kelly, Lise Munsie, Igor Tatarnikov, Patrick Chou, Sabrina Bergeron, Emma Mitchell, Roscoe Lim, Jaskaran Khinda, Alejandro Lloret, C Frank Bennett, Carmela Paradiso, Michele Morari, Matthew J Farrer, Austen J Milnerwood
信号转导
发表日期：2015
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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

LRRK2 过表达会改变谷氨酸能突触前可塑性、纹状体多巴胺张力、突触后信号转导、运动活动和记忆

期刊:Human Molecular Genetics
影响因子:3.1
doi:10.1093/hmg/ddu543
Dayne A Beccano-Kelly, Mattia Volta, Lise N Munsie, Sarah A Paschall, Igor Tatarnikov, Kimberley Co, Patrick Chou, Li-Ping Cao, Sabrina Bergeron, Emma Mitchell, Heather Han, Heather L Melrose, Lucia Tapia, Lynn A Raymond, Matthew J Farrer, Austen J Milnerwood
信号转导
发表日期：2015
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