Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells.
二价 IAP 拮抗剂（而非单价 IAP 拮抗剂）通过降解癌细胞中与 TRAF2 相关的 cIAP1 来抑制 TNF 介导的 NF-κB 信号传导
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/cddiscovery.2016.46
Mitsuuchi Y, Benetatos C A, Deng Y, Haimowitz T, Beck S C, Arnone M R, Kapoor G S, Seipel M E, Chunduru S K, McKinlay M A, Begley C G, Condon S M
