Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system
卡非佐米特异性抑制蛋白酶体β5/β2通过重塑蛋白质稳态和肾素-血管紧张素系统而导致心脏毒性。
期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2025.113228
Max Mendez-Lopez ,Andrej Besse ,Christian Zuppinger ,Christian Perez-Shibayama ,Cristina Gil-Cruz ,Bogdan I Florea ,Angelina De Martin ,Mechthild Lütge ,Deborah Beckerova ,Simon Klimovic ,Xiang Zhou ,Leo Rasche ,Jan Pribyl ,Vladimir Rotrekl ,Burkhard Ludewig ,Herman S Overkleeft ,Lenka Besse ,Christoph Driessen
