日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease

人类左心室单核多组学整合图谱揭示了心脏发育、衰老和疾病过程中基因调控网络的动态变化

Gao, William; Hu, Peng; Wick, Brittney; Qiu, Qi; Zhang, Hongjie; Li, Ying; Kang, Xiangjin; Bedi, Kenneth; Haeussler, Maximilian; Sasaki, Kotaro; Margulies, Kenneth; Wu, Hao

CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer

CPT1a表达是应对病理应激的关键心脏保护反应,可通过基因转移实现挽救。

Carley, Andrew N; Maurya, Santosh K; Maurya, Chandan K; Wang, Yang; Webb, Amy; Challa, Azariyas A; Gromova, Tatiana; Vondriska, Thomas M; Zhang, Zhentao; Zhu, Hua; Heydemann, Ahlke; Bedi, Kenneth C Jr; Kyriakopoulos, Christos P; Selzman, Craig H; Drakos, Stavros G; Margulies, Kenneth B; Lewandowski, E Douglas

Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction.

蛋白质 O-GlcNAc 糖基化和己糖激酶线粒体解离是射血分数保留型心力衰竭的驱动因素

Tatekoshi Yuki, Mahmoodzadeh Amir, Shapiro Jason S, Liu Mingyang, Bianco George M, Tatekoshi Ayumi, Camp Spencer Duncan, De Jesus Adam, Koleini Navid, De La Torre Santiago, Wasserstrom J Andrew, Dillmann Wolfgang H, Thomson Benjamin R, Bedi Kenneth C, Margulies Kenneth B, Weinberg Samuel E, Ardehali Hossein

Virally delivered CMYA5 enhances the assembly of cardiac dyads.

病毒载体递送的 CMYA5 可促进心脏二元体的组装

Lu Fujian, Liou Carter, Ma Qing, Wu Zexuan, Xue Bingqing, Xia Yu, Xia Shutao, Trembley Michael A, Ponek Anna, Xie Wenjun, Shani Kevin, Bortolin Raul H, Prondzynski Maksymilian, Berkson Paul, Zhang Xiaoran, Naya Francisco J, Bedi Kenneth C, Margulies Kenneth B, Zhang Donghui, Parker Kevin K, Pu William T

Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy

肥厚型心肌病中肌球蛋白超松弛和能量代谢的异质性失调

Ochala, Julien; Feng, Miao; Wang, Qian; Chaami, Chahida; Nollet, Edgar E; Lewis, Christopher T A; Hessel, Anthony L; Michels, Michelle; Bedi, Kenneth C Jr; Margulies, Kenneth B; Pinto, Jose R; Campbell, Kenneth S; Kuster, Diederik W D; van der Velden, Jolanda

Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure

人类心力衰竭中线粒体、脂滴和肌浆网排列的超微结构分析

Latchman, Nadina R; Stevens, Tyler L; Bedi, Kenneth C; Prosser, Benjamin L; Margulies, Kenneth B; Elrod, John W

ROR2 drives right ventricular heart failure via disruption of proteostasis

ROR2通过破坏蛋白质稳态驱动右心室衰竭

Hartman, Hali; Uy, Genevieve; Uchida, Keita; Scarborough, Emily A; Yang, Yifan; Barr, Eric; Williams, Spencer; Kavar, Sanam L; Brandimarto, Jeff; Li, Li; Lai, Ling; Griffin, Joanna; Yucel, Nora; Shewale, Swapnil; Rajagopal, Hari; Eaton, Deborah M; Dorwart, Tanis; Bedi, Kenneth C; Conn, Crystal S; Margulies, Kenneth; Prosser, Benjamin; Arany, Zoltan; Edwards, Jonathan J

Single cell transcriptomic analyses of human heart failure with preserved ejection fraction

对射血分数保留型心力衰竭患者的单细胞转录组分析

Hahn, Virginia Shalkey; Chaffin, Mark; Simonson, Bridget; Jenkin, Sydney; Mulligan, Abigail S; Bedi, Kenneth; Margulies, Kenneth B; Klattenhoff, Carla; Sharma, Kavita; Kass, David A; Ellinor, Patrick T

Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation.

桥粒斑蛋白单倍体不足是 DSP 心肌病中细胞间粘附失败的根本原因,而转录激活可以挽救这一问题

Smith Eric D, Jin Karen, Ferguson Brianna, Tsan Yao-Chang, DePalma Samuel J, Meisner Joshua, Renberg Aaron, Bedi Kenneth, Friedline Sabrina, Margulies Kenneth B, Baker Brendon M, Helms Adam S

Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

扩张型心肌病中截短的肌联蛋白整合到肌节中并传递力量。

McAfee, Quentin; Caporizzo, Matthew A; Uchida, Keita; Bedi, Kenneth C Jr; Margulies, Kenneth B; Arany, Zolt; Prosser, Benjamin L