日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

动态成像显示肿瘤中 LDH 抑制可导致体内代谢快速重编程,并对联合疗法产生敏感性

Oshima Nobu, Ishida Ryo, Kishimoto Shun, Beebe Kristin, Brender Jeffrey R, Yamamoto Kazutoshi, Urban Daniel, Rai Ganesha, Johnson Michelle S, Benavides Gloria, Squadrito Giuseppe L, Crooks Dan, Jackson Joseph, Joshi Abhinav, Mott Bryan T, Shrimp Jonathan H, Moses Michael A, Lee Min-Jung, Yuno Akira, Lee Tobie D, Hu Xin, Anderson Tamara, Kusewitt Donna, Hathaway Helen H, Jadhav Ajit, Picard Didier, Trepel Jane B, Mitchell James B, Stott Gordon M, Moore William, Simeonov Anton, Sklar Larry A, Norenberg Jeffrey P, Linehan W Marston, Maloney David J, Dang Chi V, Waterson Alex G, Hall Matthew, Darley-Usmar Victor M, Krishna Murali C, Neckers Leonard M

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

HSP90抑制剂onalespib联合泛CDK抑制剂AT7519治疗晚期实体瘤患者的I期研究

Do, Khanh T; O'Sullivan Coyne, Geraldine; Hays, John L; Supko, Jeffrey G; Liu, Stephen V; Beebe, Kristin; Neckers, Len; Trepel, Jane B; Lee, Min-Jung; Smyth, Tomoko; Gannon, Courtney; Hedglin, Jennifer; Muzikansky, Alona; Campos, Susana; Lyons, John; Ivy, Percy; Doroshow, James H; Chen, Alice P; Shapiro, Geoffrey I

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

酵母中的Hsp90辅助伴侣蛋白在人类中被位点特异性翻译后修饰所取代。

Zuehlke, Abbey D; Reidy, Michael; Lin, Coney; LaPointe, Paul; Alsomairy, Sarah; Lee, D Joshua; Rivera-Marquez, Genesis M; Beebe, Kristin; Prince, Thomas; Lee, Sunmin; Trepel, Jane B; Xu, Wanping; Johnson, Jill; Masison, Daniel; Neckers, Len

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands

通过合理设计的变构配体激活Hsp90酶活性和构象动力学

Sattin, Sara; Tao, Jiahui; Vettoretti, Gerolamo; Moroni, Elisabetta; Pennati, Marzia; Lopergolo, Alessia; Morelli, Laura; Bugatti, Antonella; Zuehlke, Abbey; Moses, Mike; Prince, Thomas; Kijima, Toshiki; Beebe, Kristin; Rusnati, Marco; Neckers, Len; Zaffaroni, Nadia; Agard, David A; Bernardi, Anna; Colombo, Giorgio

Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas

联合应用 HSP90 和激酶抑制剂疗法:来自癌症基因组图谱的启示

Schwartz, Harvey; Scroggins, Brad; Zuehlke, Abbey; Kijima, Toshiki; Beebe, Kristin; Mishra, Alok; Neckers, Len; Prince, Thomas

Regulation and function of the human HSP90AA1 gene

人类 HSP90AA1 基因的调控和功能

Zuehlke, Abbey D; Beebe, Kristin; Neckers, Len; Prince, Thomas

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models

HSP90抑制剂ganetespib与MET激酶抑制剂crizotinib在对crizotinib敏感和耐药的MET驱动肿瘤模型中均具有协同作用。

Miyajima, Naoto; Tsutsumi, Shinji; Sourbier, Carole; Beebe, Kristin; Mollapour, Mehdi; Rivas, Candy; Yoshida, Soichiro; Trepel, Jane B; Huang, Ying; Tatokoro, Manabu; Shinohara, Nobuo; Nonomura, Katsuya; Neckers, Len

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

基于亲和力的蛋白质组学揭示了由Hsp90协调的癌症特异性网络

Moulick, Kamalika; Ahn, James H; Zong, Hongliang; Rodina, Anna; Cerchietti, Leandro; Gomes DaGama, Erica M; Caldas-Lopes, Eloisi; Beebe, Kristin; Perna, Fabiana; Hatzi, Katerina; Vu, Ly P; Zhao, Xinyang; Zatorska, Danuta; Taldone, Tony; Smith-Jones, Peter; Alpaugh, Mary; Gross, Steven S; Pillarsetty, Nagavarakishore; Ku, Thomas; Lewis, Jason S; Larson, Steven M; Levine, Ross; Erdjument-Bromage, Hediye; Guzman, Monica L; Nimer, Stephen D; Melnick, Ari; Neckers, Len; Chiosis, Gabriela

Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells

CIB1在乳腺癌细胞中对polo样激酶3活性的钙依赖性抑制

Naik, Meghna U; Pham, Ngoc T; Beebe, Kristin; Dai, Wei; Naik, Ulhas P

Inhibition of HSP90 with pochoximes: SAR and structure-based insights

利用pochoxime抑制HSP90:构效关系及基于结构的见解

Barluenga, Sofia; Fontaine, Jean-Gonzague; Wang, Cuihua; Aouadi, Kais; Chen, Ruihong; Beebe, Kristin; Neckers, Len; Winssinger, Nicolas