日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages

舌后部的三能性Lgr5干细胞可分化生成舌腺、味腺和唾液腺谱系。

Laurens H G Verweij #,Seok-Young Kim #,Dimitrios Laskaris,Lin Lin,Gijs J F van Son,Femke C A S Ringnalda,Harry Begthel,Ravian L van Ineveld,Chris Winkel,Jay P Slack,Anne C Rios,Karin Sanders,Jacco van Rheenen,Marc van de Wetering,Hans Clevers

Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients

肠道绒毛细胞亚型代表了由隐窝-绒毛信号梯度驱动的连续成熟阶段。

Julian R Buissant des Amorie ,Max A Betjes ,Jochem H Bernink ,Joris H Hageman ,Veerle E Geurts ,Harry Begthel ,Dimitrios Laskaris ,Maria C Heinz ,Ingrid Jordens ,Tiba Vinck ,Ronja M Houtekamer ,Ingrid Verlaan-Klink ,Sascha R Brunner ,Jacco van Rheenen ,Martijn Gloerich ,Hans Clevers ,Sander J Tans ,Jeroen S van Zon ,Hugo J G Snippert

Invasin-functionalized PIC hydrogels enable long-term 3D culture of epithelial organoids

侵袭素功能化的PIC水凝胶能够实现上皮类器官的长期三维培养

Wijnakker, Joost J A P M; Lim, Sangho; Schreurs, Robin; Faria, João Ferreira; Korving, Jeroen; Begthel, Harry; Iyer, Kirti K; Kouwer, Paul H J; Clevers, Hans

Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids

铜绿假单胞菌与人类二维上呼吸道类器官共培养模型的双 RNA 测序

Cayetano Pleguezuelos-Manzano #, Wouter A G Beenker #, Gijs J F van Son, Harry Begthel, Gimano D Amatngalim, Jeffrey M Beekman, Hans Clevers, Jeroen den Hertog1

Tuft cells act as regenerative stem cells in the human intestine

簇状细胞在人体肠道中发挥着再生干细胞的作用。

Lulu Huang # ,Jochem H Bernink # ,Amir Giladi # ,Daniel Krueger ,Gijs J F van Son ,Maarten H Geurts ,Georg Busslinger ,Lin Lin ,Harry Begthel ,Maurice Zandvliet ,Christianne J Buskens ,Willem A Bemelman ,Carmen López-Iglesias ,Peter J Peters ,Hans Clevers

Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

通过在错配修复缺陷的人类结肠类器官中选择四种自发致癌突变来重现腺瘤-癌序列

Tomohiro Mizutani #, Matteo Boretto #, Sangho Lim, Jarno Drost, Diego Montiel González, Rurika Oka, Maarten H Geurts, Harry Begthel, Jeroen Korving, Johan H van Es, Ruben van Boxtel, Hans Clevers

Human conjunctiva organoids to study ocular surface homeostasis and disease

人类结膜类器官用于研究眼表稳态和疾病

Marie Bannier-Hélaouët, Jeroen Korving, Ziliang Ma, Harry Begthel, Amir Giladi, Mart M Lamers, Willine J van de Wetering, Nobuyo Yawata, Makoto Yawata, Vanessa L S LaPointe, Mor M Dickman, Rachel Kalmann, Saskia M Imhoff, Johan H van Es, Carmen López-Iglesias, Peter J Peters, Bart L Haagmans, Wei Wu

Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients

肌球蛋白过度松弛会导致机械通气患者的呼吸肌进入休眠状态。

van den Berg, Marloes; Shi, Zhonghua; Claassen, Wout J; Hooijman, Pleuni; Lewis, Christopher T A; Andersen, Jesper L; van der Pijl, Robbert J; Bogaards, Sylvia J P; Conijn, Stefan; Peters, Eva L; Begthel, Leon P L; Uijterwijk, Bas; Lindqvist, Johan; Langlais, Paul R; Girbes, Armand R J; Stapel, Sandra; Granzier, Henk; Campbell, Kenneth S; Ma, Weikang; Irving, Thomas; Hwee, Darren T; Hartman, James J; Malik, Fady I; Paul, Marinus; Beishuizen, Albertus; Ochala, Julien; Heunks, Leo; Ottenheijm, Coen A C

Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

表皮生长因子受体 (EGFR) 是肿瘤抑制因子 E3 连接酶 FBXW7 的靶标

Matteo Boretto #, Maarten H Geurts #, Shashank Gandhi #, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

通过碱基编辑器多路复用在成体干细胞衍生的类器官中一步生成肿瘤模型

Maarten H Geurts #, Shashank Gandhi #, Matteo G Boretto #, Ninouk Akkerman, Lucca L M Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M Chuva de Sousa Lopes, Johan H van Es, Ruben van Boxtel, Han