日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

亨廷顿病 LIG1 修饰基因变体可提高连接酶的保真度并抑制体细胞 CAG 重复序列扩增。

Lee, Eunhye; Kim, Wonju; Beier, David H; Lee, Yejin; Kovalenko, Marina; Saif, Faaiza; Oliver, Esaria; Srinageshwar, Bhairavi; Murtha, Ryan; Andrew, Marissa A; Jiang, Andrew; Gillis, Tammy; Demelo, Brigitte; Ruliera, Jayla; Lucente, Diane; Kwak, Seung; Lee, Ramee; Pinto, Ricardo Mouro; MacDonald, Marcy E; Gusella, James F; O'Brien, Patrick J; Wheeler, Vanessa C; Seong, Ihn Sik

Fidelity of DNA ligase I is sensitive to physiological Mg(2+) level

DNA连接酶I的保真度对生理Mg(2+)水平敏感

Beier, David H; Lee, Eunhye; Seong, Ihn Sik; Wheeler, Vanessa C; O'Brien, Patrick J

Localized ribosome access and distal tuning via the Listeria prfA RNA thermometer

通过李斯特菌prfA RNA温度计实现局部核糖体接近和远端调控

O'Steen, Martin R; Chen, Jocelyn V; Beier, David H; Walter, Nils G; Keane, Sarah C

A Sensitized ENU Mutagenesis Screen for Thrombosis Modifiers Identifies Suppressor Variants in Non-mutagenized Parental Generations Due to Antithrombotic Selective Pressures

针对血栓形成修饰因子的敏感ENU诱变筛选,由于抗血栓选择压力,在未诱变亲代中发现了抑制性变异体。

Brake, Marisa A; Cleuren, Audrey C; Torres, Sydney; van der Ent, Martijn A; Zhu, Guojing; Kulchycki, Justin; Parsons, Tyler M; Schneider, Caitlin D; Jurek, Adrianna M; MacFadyen, Kailey; Siebert, Amy E; Siemieniak, David R; Timms, Andrew E; Beier, David R; Westrick, Randal J

The response to kidney injury is epigenetically regulated through the activation of bivalent genes

肾损伤的反应是通过激活二价基因进行表观遗传调控的。

Tickman, Benjamin I; McDonald, Jacquelyn R; McCarthy, Ryan; Suh, Kiheon; Okamura, Daryl M; Houghtaling, Scott R; Collins, Sarah J; Bae, Yeji; Beier, David R; Majesky, Mark W; Nguyen, Elizabeth Dong

A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects.

系统遗传学方法揭示了蛋白酶体因子在心脏发育和先天性心脏缺陷中的作用

Farr Gist H III, Reid Whitaker, Hasegawa Eva H, Azzam Azzam, Young Isabelle, Li Mona L, Olson Aaron K, Beier David R, Maves Lisa

Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model.

在 Pkd1 突变小鼠模型中,抑制 Hedgehog 信号传导并不能减轻多囊肾病的严重程度

Gombart Sean K, Houghtaling Scott, Ho Tzu-Hua, Beier David R

A conditional smoothened (smo) allele on an inbred C57BL/6J genetic background has a hypomorphic smo mutant phenotype

在近交系 C57BL/6J 遗传背景下,条件性 smoothened (smo) 等位基因表现出 smo 突变体低效表型

Houghtaling, Scott; Gombart, Sean K; Ho, Tzu-Hua; Huang, Grace; Beier, David R

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion.

亨廷顿病 LIG1 修饰变体可提高连接酶的保真度并抑制体细胞 CAG 重复扩增

Lee Eunhye, Kim Wonju, Beier David H, Lee Yejin, Kovalenko Marina, Saif Faaiza, Oliver Esaria, Murtha Ryan, Andrew Marissa A, Gillis Tammy, Demelo Brigitte, Srinageshwar Bhairavi, Ruliera Jayla, Lucente Diane, Kwak Seung, Lee Ramee, Pinto Ricardo Mouro, MacDonald Marcy E, Gusella James F, O'Brien Patrick J, Wheeler Vanessa C, Seong Ihn Sik

Mammalian organ regeneration in spiny mice

棘鼠的哺乳动物器官再生

Okamura, Daryl M; Nguyen, Elizabeth D; Collins, Sarah J; Yoon, Kevin; Gere, Joshua B; Weiser-Evans, Mary C M; Beier, David R; Majesky, Mark W