日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo design of potent inhibitors of clostridial family toxins

从头设计高效梭菌毒素抑制剂

Ragotte, Robert J; Liang, Huazhu; Tam, John; Miletic, Sean; Berman, Jacob M; Palou, Roger; Weidle, Connor; Li, Zhijie; Glögl, Matthias; Beilhartz, Greg L; Carr, Kenneth D; Borst, Andrew J; Coventry, Brian; Wang, Xinru; Rubinstein, John L; Tyers, Mike; Schramek, Daniel; Melnyk, Roman A; Baker, David

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

一种基于远缘白喉毒素同源物的增强型细胞内递送平台,可逃避预先存在的抗毒素抗体。

Shivneet K Gill,Seiji N Sugiman-Marangos,Greg L Beilhartz,Elizabeth Mei,Mikko Taipale,Roman A Melnyk

Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

梭菌致死毒素对信号蛋白的识别揭示了梭菌毒素受体特异性的原理

Hunsang Lee,Greg L Beilhartz,Iga Kucharska,Swetha Raman,Hong Cui,Mandy Hiu Yi Lam,Huazhu Liang,John L Rubinstein,Daniel Schramek,Jean-Philippe Julien,Roman A Melnyk,Mikko Taipale

Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy

利用白喉毒素内化受体增强蛋白质向溶酶体的输送,用于酶替代疗法

Seiji N Sugiman-Marangos, Greg L Beilhartz, Xiaochu Zhao, Dongxia Zhou, Rong Hua, Peter K Kim, James M Rini, Berge A Minassian, Roman A Melnyk

Attenuated diphtheria toxin mediates siRNA delivery

减毒白喉毒素介导 siRNA 递送

Amy E Arnold, Laura J Smith, Greg L Beilhartz, Laura C Bahlmann, Emma Jameson, Roman A Melnyk, Molly S Shoichet

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

bioPROTACs 作为细胞内治疗靶点(包括增殖细胞核抗原 (PCNA))的多功能调节剂

Lim, Shuhui; Khoo, Regina; Peh, Khong Ming; Teo, Jinkai; Chang, Shih Chieh; Ng, Simon; Beilhartz, Greg L; Melnyk, Roman A; Johannes, Charles W; Brown, Christopher J; Lane, David P; Henry, Brian; Partridge, Anthony W

An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

一种经基因工程改造的嵌合毒素,能够切割活化的突变型和野生型RAS蛋白,从而抑制肿瘤生长。

Vidimar, Vania; Beilhartz, Greg L; Park, Minyoung; Biancucci, Marco; Kieffer, Matthew B; Gius, David R; Melnyk, Roman A; Satchell, Karla J F

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

宿主靶向氯硝柳胺可抑制艰难梭菌的毒力,并在不破坏肠道菌群的情况下预防小鼠发病

John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L Beilhartz, Jacques Ravel, Hanping Feng, Roman A Melnyk