Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies
结构导向设计可优化多特异性卷曲抗体的药代动力学、耐受性和抗肿瘤活性。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1817246116
Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine; Jmeian, Yazen; Ng, Mark; Fernandez, Minerva; Fu, Ying; Mascall, Keith; Duque, Alejandro; Wang, Xiaowei; Pan, Guohua; Angers, Stephane; Moffat, Jason; Sidhu, Sachdev S; Magram, Jeanne; Sinclair, Angus M; Fransson, Johan; Julien, Jean-Philippe
