日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Early peripheral immune signaling precedes tau elevation and blood-brain barrier disruption in Alzheimer's disease

阿尔茨海默病早期外周免疫信号先于tau蛋白升高和血脑屏障破坏。

Burberry, Aaron; Benchek, Penelope; Lowe, Mark; Shin, Wanyong; McCourt, Blake; Beamon, Quintasha; Chakrabarti, Shinjon; Ramaiah, Sara; Woidke, Elizabeth; Khrestian, Maria; Maecker, Holden; Bekris, Lynn M; Rao, Stephen; Ontaneda, Daniel; Leverenz, James B; Bush, William; Pillai, Jagan A

Performance of (123)I-ioflupane SPECT striatal binding in dementia with Lewy bodies

(123)I-碘氟烷SPECT纹状体结合在路易体痴呆患者中的表现

Maly, Emily F; DiFilippo, Frank P; Lapin, Brittany; Li, Yadi; Berman, Sarah; Bozoki, Andrea C; Fleisher, Jori E; Galvin, James E; Irwin, David J; Lippa, Carol F; Litvan, Irene; Tsuang, Debby W; Zabetian, Cyrus P; Taylor, Angela S; Bekris, Lynn M; Lopez, Oscar L; Galasko, Douglas; Leverenz, James B

CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression

脑脊液α-突触核蛋白种子扩增检测和路易体痴呆症的阿尔茨海默病生物标志物:表现和进展

Coughlin, David G; Jain, Lavanya; Khrestian, Maria; Bozoki, Andrea C; Galvin, James E; Irwin, David John; Lippa, Carol F; Litvan, Irene; Pillai, Jagan A; Tousi, Babak; Lopez, Oscar L; Berman, Sarah; Tsuang, Debby W; Zabetian, Cyrus P; Fleisher, Jori E; Taylor, Angela S; Leverenz, James B; Bekris, Lynn M; Galasko, Douglas

Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers.

一项针对老年、认知功能正常的 APOE α4 携带者进行为期 18 个月的家庭高强度运动干预的随机、单盲、对照试验方案

Rao Stephen M, Chorba Alexandria L, Helppi M J, Tuladhar Alina, Penko Amanda L, Holley Sarah, Nehls Brandon, Paulino Sabrina, Streicher Matthew C, Zhu Audrey, Bruening Kellie, Durgerian Sally, Koenig Katherine, Lowe Mark, Shin Wanyong, Jones Stephen E, Galioto Rachel, Pillai Jagan A, Bekris Lynn M, Leverenz James B, Rosenfeldt Anson B, Singh Tamanna, Beck Gerald J, Smith J Carson, Alberts Jay

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model.

聚(ADP-核糖)聚合酶 1 缺乏可减轻家族性阿尔茨海默病模型中的淀粉样蛋白病理、神经退行性变和认知衰退。

Jhaldiyal Aanishaa, Kumari Manisha, Tripathi Trupti, Khan Mohammed Repon, Wang Justin, Guttman Lauren, Biswas Devanik, Pasupuleti Abhishek, Aggarwal Akansha, Pandya Shraddha, Chou Shih-Ching, Panicker Nikhil, Monghekar Abhay, Albert Marilyn, Bekris Lynn M, Leverenz James B, Kam Tae-In, Dawson Ted M, Dawson Valina L

A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms

利用计算方法系统地搜索TREM2选择性剪接异构体的相互作用伙伴

Liang, Junyi; Menon, Aditya; Tomco, Taylor; Bhattarai, Nisha; Smith, Iris Nira; Khrestian, Maria; Formica, Shane V; Eng, Charis; Buck, Matthias; Bekris, Lynn M

Synuclein Aggregate Assay Performance in Autopsy‐Confirmed Lewy Body Dementia: Results from the U.S. Dementia with Lewy Bodies Consortium

尸检确诊的路易体痴呆症中突触核蛋白聚集体检测的性能:来自美国路易体痴呆症联盟的结果

Bryant, Bronwyn H; Bettinetti‐Luque, Miriam; Trujillo‐Estrada, Laura; Andreo‐Lopez, Juana; Campos‐Moreno, Cynthia; Morales‐Cabello, Mario; Perea‐Santaella, Ian; Sanchez‐Mejias, Elisabeth; Cunha, Celia Da; LaFerla, Frank M; Sanchez‐Varo, Raquel; Gutierrez, Antonia; Baglietto‐Vargas, David; Leverenz, James B; Patel, Purvi; Formica, Shane; Bekris, Lynn M; Tsuang, Debby W; Zabetian, Cyrus P; Litvan, Irene; Fleisher, Jori E; Berman, Sarah; Irwin, David J; Bozoki, Andrea; Lippa, Carol; Lopez, Oscar L; Galasko, Douglas R

Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease

利用可解释的深度学习方法转化全基因组关联研究(GWAS)和多组学研究结果,以识别阿尔茨海默病的病理生物学和药物重定位。

Xu, Jielin; Mao, Chengsheng; Hou, Yuan; Luo, Yuan; Binder, Jessica L; Zhou, Yadi; Bekris, Lynn M; Shin, Jiyoung; Hu, Ming; Wang, Fei; Eng, Charis; Oprea, Tudor I; Flanagan, Margaret E; Pieper, Andrew A; Cummings, Jeffrey; Leverenz, James B; Cheng, Feixiong

Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer's Disease

阿尔茨海默病早期阶段外周sTREM2相关炎症活性改变

Weber, Grace E; Khrestian, Maria; Tuason, Elizabeth D; Shao, Yvonne; Pillai, Jagan; Rao, Stephen; Feng, Hao; Zhou, Yadi; Cheng, Feixiong; DeSilva, Tara M; Stauffer, Shaun; Leverenz, James B; Bekris, Lynn M

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery

AlzGPS:一个全基因组定位系统平台,旨在促进多组学在阿尔茨海默病药物研发中的应用

Zhou, Yadi; Fang, Jiansong; Bekris, Lynn M; Kim, Young Heon; Pieper, Andrew A; Leverenz, James B; Cummings, Jeffrey; Cheng, Feixiong