日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B

The N=1 Collaborative: advancing customized nucleic acid therapies through collaboration and data sharing

N=1协作项目:通过合作和数据共享推进定制化核酸疗法

Belgrad, Jillian; McConnell, Erin; Leonard, Stef; Nolen, Nicole; Lauffer, Marlen C; Watts, Jonathan K; Yu, Timothy; Yan, Winston X; Aartsma-Rus, Annemieke

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

RNAi介导的SOD1基因沉默显著延长了ALS小鼠的生存期并改善了其功能预后。

Weiss, Alexandra; Gilbert, James W; Rivera Flores, Iris Valeria; Belgrad, Jillian; Ferguson, Chantal; Dogan, Elif O; Wightman, Nicholas; Mocarski, Kit; Echeverria, Dimas; Harkins, Ashley L; Summers, Ashley; Bramato, Brianna; McHugh, Nicholas; Furgal, Raymond; Yamada, Nozomi; Cooper, David; Monopoli, Kathryn; Godinho, Bruno M D C; Hassler, Matthew R; Yamada, Ken; Greer, Paul; Henninger, Nils; Brown, Robert H Jr; Khvorova, Anastasia

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation.

利用新表位抗体在小鼠脑中检测到突变亨廷顿蛋白外显子 1 蛋白:CAG 重复扩增、MutS 同源物 3 沉默和聚集的影响

Sapp Ellen, Boudi Adel, Iwanowicz Andrew, Belgrad Jillian, Miller Rachael, Robertson Riannon, O'Reilly Daniel, Yamada Ken, Deng Yunping, Joni Marion, Li Xueyi, Kegel-Gleason Kimberly, Khvorova Anastasia, Reiner Anton, Aronin Neil, DiFiglia Marian

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation

利用新表位抗体在小鼠脑中检测到突变型亨廷顿蛋白外显子1:CAG重复序列扩增、MSH3沉默和聚集的影响

Sapp, Ellen; Boudi, Adel; Iwanowicz, Andrew; Belgrad, Jillian; Miller, Rachael; Robertson, Riannon; O'Reilly, Daniel; Yamada, Ken; Deng, Yunping; Joni, Marion; Li, Xueyi; Kegel-Gleason, Kimberly; Khvorova, Anastasia; Reiner, Anton; Aronin, Neil; DiFiglia, Marian

Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018-2023

社论:核酸研究虚拟特刊,聚焦核酸疗法,2018-2023

Belgrad, Jillian; Fakih, Hassan H; Johnson, Krystal C; Corey, David R

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.

可编程双靶向siRNA支架支持中枢神经系统中有效的双基因调控

Belgrad Jillian, Tang Qi, Hildebrand Sam, Summers Ashley, Sapp Ellen, Echeverria Dimas, O'Reilly Dan, Luu Eric, Bramato Brianna, Allen Sarah, Cooper David, Alterman Julia, Yamada Ken, Aronin Neil, DiFiglia Marian, Khvorova Anastasia

More than 185 CAG repeats: a point of no return in Huntington's disease biology

超过185个CAG重复序列:亨廷顿病生物学中的一个不可逆转的转折点

Belgrad, Jillian; Khvorova, Anastasia

Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation

核酸疗法:成功案例、里程碑及未来创新

Belgrad, Jillian; Fakih, Hassan H; Khvorova, Anastasia