Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.
二甲双胍会降低葡萄糖氧化,并增加前列腺癌细胞对还原性谷氨酰胺代谢的依赖性
期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-13-0080
Fendt Sarah-Maria, Bell Eric L, Keibler Mark A, Davidson Shawn M, Wirth Gregory J, Fiske Brian, Mayers Jared R, Schwab Matthias, Bellinger Gary, Csibi Alfredo, Patnaik Akash, Blouin Marie Jose, Cantley Lewis C, Guarente Leonard, Blenis John, Pollak Michael N, Olumi Aria F, Vander Heiden Matthew G, Stephanopoulos Gregory