日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights

基因组学将肥胖和2型糖尿病与阿尔茨海默病联系起来,揭示了新的生物学见解

Cunha, César; Garcia-Ureña, Mario; Martínez, Raquel; Romero-Lado, María José; Fernandez, Maria Victoria; Andreassen, Ole A; Sims, Rebecca; Tsolaki, Magda; Sleegers, Kristel; Hiltunen, Mikko; Nicolas, Gaël; Sánchez-Juan, Pascual; Ingelsson, Martin; Giedraitis, Vilmantas; Ghidoni, Roberta; Holstege, Henne; van Duijn, Cornelia; van der Lee, Sven; Ramirez, Alfredo; Bellenguez, Céline; Lambert, Jean-Charles; Frikke-Schmidt, Ruth; Kilpeläinen, Tuomas O; Loos, Ruth J F

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

非小胶质细胞中 PLCG2 的下调会损害突触功能,并引发阿尔茨海默病相关的特征。

Coulon Audrey, Rabiller Florian, Takalo Mari, Roy Avishek, Pelletier Alexandre, Martiskainen Henna, Siedlecki-Wullich Dolores, Lannette-Weimann Nina, Majerníková Nad'a, Grenon Arthur, Gao Vance, Erhardt Anaël, Pernodet Anne, Lemaire Morgane, Limoge Floriane, Walle Pauline, Mendes Tiago, Guyot Karine, Lemeu Célia, Carvalho Lukas-Iohan, de Farias Ana Raquel Melo, Hulsman Marc, Najdek Chloé, Freire-Regatillo Alejandra, Saha Orthis, Amouyel Philippe, Charbonnier Camille, Deleuze Jean-François, Dols-Icardo Orio, Jeskanen Heli, Willman Roosa-Maria, Kuulasmaa Teemu, Kurki Mitja, Hardy John, Heikkinen Sami, Holstege Henne, Mäkinen Petra, Nicolas Gaël, Mead Simon, Wagner Michael, Ramirez Alfredo, Rauramaa Tuomas, Palotie Aarno, Sims Rebecca, Soininen Hilkka, van Swieten John, Williams Julie, Bellenguez Céline, Gelle Carla, Lambert Erwan, Costa Marcos R, Tcw Julia, Glaab Enrico, Ayral Anne-Marie, Demiautte Florie, Grenier-Boley Benjamin, Muntaner Manon, Eberlé Delphine, Deforges Séverine, Haas Joel, Kilinc Devrim, Mulle Christophe, Chapuis Julien, Hiltunen Mikko, Dumont Julie, Lambert Jean-Charles

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

欧洲人群阿尔茨海默病多基因风险评分在不同族裔人群中的适用性

Nicolas, Aude; Sherva, Richard; Grenier-Boley, Benjamin; Kim, Yoontae; Kikuchi, Masataka; Timsina, Jigyasha; de Rojas, Itziar; Dalmasso, María Carolina; Zhou, Xiaopu; Le Guen, Yann; Arboleda-Bustos, Carlos E; Camargos Bicalho, Maria Aparecida; Guerchet, Maëlenn; van der Lee, Sven; Goss, Monica; Castillo, Atahualpa; Bellenguez, Céline; Küçükali, Fahri; Satizabal, Claudia L; Fongang, Bernard; Yang, Qiong; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Pastor, Pau; Sánchez-Valle, Raquel; Álvarez, Victoria; Cao, Han; Ip, Nancy Y; Fu, Amy K Y; Ip, Fanny C F; Olivar, Natividad; Muchnik, Carolina; Cuesta, Carolina; Campanelli, Lorenzo; Solis, Patricia; Politis, Daniel Gustavo; Kochen, Silvia; Brusco, Luis Ignacio; Boada, Mercè; García-González, Pablo; Puerta, Raquel; Mir, Pablo; Real, Luis M; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Royo, Jose Luís; Rodriguez-Rodriguez, Eloy; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Rasmussen, Katrine Laura; Thomassen, Jesper Qvist; Pijnenburg, Yolande A L; Holstege, Henne; van Swieten, John C; Seelaar, Harro; Claassen, Jurgen A H R; Jansen, Willemijn J; Ramakers, Inez; Verhey, Frans; van der Lugt, Aad; Scheltens, Philip; Ortega-Rojas, Jenny; Concha Mera, Ana Gabriela; Mahecha, Maria F; Pardo, Rodrigo; Arboleda, Gonzalo; Bahrami, Shahram; Fominykh, Vera; Selbæk, Geir; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Boland, Anne; Deleuze, Jean-François; de Marco, Luiz Armando; de Moraes, Edgar Nunes; de Mattos Viana, Bernardo; Túlio Gualberto Cintra, Marco; Juarez-Cedillo, Teresa; Griswold, Anthony J; Forund, Tatiana; Haines, Jonathan; Farrer, Lindsay; DeStefano, Anita; Wijsman, Ellen; Mayeux, Richard; Pericak-Vance, Margaret; Kunkle, Brian; Goate, Alison; Schellenberg, Gerard D; Vardarajan, Badri; Wang, Li-San; Leung, Yuk Yee; Dalgard, Clifton L; Nicolas, Gael; Wallon, David; Dufouil, Carole; Pasquier, Florence; Hanon, Olivier; Debette, Stéphanie; Grünblatt, Edna; Popp, Julius; Angel, Bárbara; Gloger, Sergio; Chacon, Maria Victoria; Aranguiz, Rafael; Orellana, Paulina; Slachevsky, Andrea; Gonzalez-Billault, Christian; Albala, Cecilia; Fuentes, Patricio; Sachdev, Perminder; Mather, Karen A; Hauger, Richard L; Merritt, Victoria; Panizzon, Matthew; Zhang, Rui; Gaziano, J Michael; Ghidoni, Roberta; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Solfrizzi, Vincenzo; Parnetti, Lucilla; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Nacmias, Benedetta; Caffarra, Paolo; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Leonard, Hampton L; Yokoyama, Jenifer S; Nalls, Mike A; Miyashita, Akinori; Hara, Norikazu; Ozaki, Kouichi; Niida, Shumpei; Williams, Julie; Masullo, Carlo; Amouyel, Philippe; Preux, Pierre-Marie; Mbelesso, Pascal; Bandzouzi, Bébène; Saykin, Andy; Jessen, Frank; Kehoe, Patrick G; Van Duijn, Cornelia; Ben Salem, Nesrine; Frikke-Schmidt, Ruth; Cherni, Lotfi; Greicius, Michael D; Tsolaki, Magda; Sánchez-Juan, Pascual; Romano Silva, Marco Aurélio; Porter, Tenielle; Laws, Simon M; Sleegers, Kristel; Ingelsson, Martin; Dartigues, Jean-François; Seshadri, Sudha; Rossi, Giacomina; Morelli, Laura; Hiltunen, Mikko; Sims, Rebecca; van der Flier, Wiesje; Andreassen, Ole A; Arboleda, Humberto; Cruchaga, Carlos; Escott-Price, Valentina; Ruiz, Agustín; Lee, Kun Ho; Ikeuchi, Takeshi; Ramirez, Alfredo; Gim, Jungsoo; Logue, Mark; Lambert, Jean-Charles

Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease

疾病突变的结构域定位揭示了阿尔茨海默病中的致病性SORL1变异

Andersen, Olav M; de Waal, Matthijs W J; Monti, Giulia; Tesi, Niccolo; Jensen, Anne Mette G; de Geus, Christa; van Spaendonk, Rosalina; Vogel, Maartje; Ahmad, Shahzad; Amin, Najaf; Amouyel, Philippe; Beecham, Gary W; Bellenguez, Céline; Berr, Claudine; Bis, Joshua C; Boland, Anne; Bossù, Paola; Bouwman, Femke; Bras, Jose; Charbonnier, Camille; Clarimon, Jordi; Cruchaga, Carlos; Daniele, Antonio; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Denning, Nicola; DeStefano, Anita L; Dols-Icardo, Oriol; van Duijn, Cornelia M; Farrer, Lindsay A; Fernández, Maria Victoria; van der Flier, Wiesje M; Fox, Nick C; Galimberti, Daniela; Genin, Emmanuelle; Gille, Johan J P; Grenier-Boley, Benjamin; Grozeva, Detelina; Guen, Yann Le; Guerreiro, Rita; Haines, Jonathan L; Holmes, Clive; Hummerich, Holger; Arfan Ikram, M; Kamran Ikram, M; Kawalia, Amit; Kraaij, Robert; Lambert, Jean-Charles; Lathrop, Marc; Lemstra, Afina W; Lleó, Alberto; Myers, Richard M; Mannens, Marcel M A M; Marshall, Rachel; Martin, Eden R; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Meggy, Alun; Mol, Merel O; Nacmias, Benedetta; Naj, Adam C; Napolioni, Valerio; Nicholas Cochran, J; Nicolas, Gaël; Pasquier, Florence; Pastor, Pau; Pericak-Vance, Margaret A; Pijnenburg, Yolande A L; Piras, Fabrizio; Quenez, Olivier; Ramirez, Alfredo; Raybould, Rachel; Redon, Richard; Reinders, Marcel J T; Richard, Anne-Claire; Riedel-Heller, Steffi G; Rivadeneira, Fernando; van Rooij, Jeroen G J; Rousseau, Stéphane; Ryan, Natalie S; Sanchez-Juan, Pascual; Schellenberg, Gerard D; Scheltens, Philip; Schott, Jonathan M; Seshadri, Sudha; Sie, Daoud; Sims, Rebecca; Sistermans, Erik A; Sorbi, Sandro; van Swieten, John C; Tijms, Betty; Uitterlinden, André G; Visser, Pieter Jelle; Wagner, Michael; Wallon, David; Wang, Li-San; Williams, Julie; Yokoyama, Jennifer S; Zarea, Aline; van der Lee, Sven J; Olsen, Johan G; Hulsman, Marc; Holstege, Henne

Machine learning in Alzheimer's disease genetics

机器学习在阿尔茨海默病遗传学中的应用

Bracher-Smith, Matthew; Melograna, Federico; Ulm, Brittany; Bellenguez, Céline; Grenier-Boley, Benjamin; Duroux, Diane; Nevado, Alejo J; Holmans, Peter; Tijms, Betty M; Hulsman, Marc; de Rojas, Itziar; Campos-Martin, Rafael; der Lee, Sven van; Castillo, Atahualpa; Küçükali, Fahri; Peters, Oliver; Schneider, Anja; Dichgans, Martin; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Düzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Pastor, Pau; Sánchez-Valle, Raquel; Álvarez, Victoria; Boada, Mercè; García-González, Pablo; Puerta, Raquel; Mir, Pablo; Real, Luis M; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Rodriguez-Rodriguez, Eloy; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Sandau, Nicolai; Thomassen, Jesper Qvist; Pijnenburg, Yolande A L; Holstege, Henne; van Swieten, John; Ramakers, Inez; Verhey, Frans; Scheltens, Philip; Graff, Caroline; Papenberg, Goran; Giedraitis, Vilmantas; Williams, Julie; Amouyel, Philippe; Boland, Anne; Deleuze, Jean-François; Nicolas, Gael; Dufouil, Carole; Pasquier, Florence; Hanon, Olivier; Debette, Stéphanie; Grünblatt, Edna; Popp, Julius; Ghidoni, Roberta; Galimberti, Daniela; Arosio, Beatrice; Mecocci, Patrizia; Solfrizzi, Vincenzo; Parnetti, Lucilla; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Wagner, Michael; Nacmias, Benedetta; Spallazzi, Marco; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Masullo, Carlo; Rossi, Giacomina; Jessen, Frank; Kehoe, Patrick; Magda, Tsolaki; Sánchez-Juan, Pascual; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Sims, Rebecca; van der Flier, Wiesje; Andreassen, Ole A; Ruiz, Agustín; Ramirez, Alfredo; Frikke-Schmidt, Ruth; Amin, Najaf; Roshchupkin, Gennady; Lambert, Jean-Charles; Van Steen, Kristel; van Duijn, Cornelia; Escott-Price, Valentina

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease

单等位基因 TYROBP 缺失是阿尔茨海默病的一个新的风险因素

Henna Martiskainen # ,Roosa-Maria Willman # ,Päivi Harju ,Sami Heikkinen ,Mette Heiskanen ,Stephan A Müller ,Rosa Sinisalo ,Mari Takalo ,Petra Mäkinen ,Teemu Kuulasmaa ,Viivi Pekkala ,Ana Galván Del Rey ,Sini-Pauliina Juopperi ,Heli Jeskanen ,Inka Kervinen ,Kirsi Saastamoinen ,Sami V Heikkinen ,Mitja I Kurki ,Jarkko Marttila ,Petri I Mäkinen ,Hannah Rostalski ,Tomi Hietanen ,Tiia Ngandu ,Jenni Lehtisalo ,Céline Bellenguez ,Jean-Charles Lambert ,Christian Haass ,Juha Rinne ,Juhana Hakumäki ,Tuomas Rauramaa ,Johanna Krüger ,Hilkka Soininen ,Annakaisa Haapasalo ,Stefan F Lichtenthaler ,Ville Leinonen ,Eino Solje ,Mikko Hiltunen

Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study.

芬兰和挪威特发性正常压力脑积水患者中 CWH43 变异体的患病率较低:一项基于队列的观察性研究

Räsänen Joel, Helisalmi Seppo, Heikkinen Sami, Raivo Joose, Korhonen Ville E, Martiskainen Henna, Junkkari Antti, Grenier-Boley Benjamin, Bellenguez Céline, Oinas Minna, Avellan Cecilia, Frantzen Janek, Kotkansalo Anna, Rinne Jaakko, Ronkainen Antti, Kauppinen Mikko, von Und Zu Fraunberg Mikael, Lönnrot Kimmo, Satopää Jarno, Perola Markus, Koivisto Anne M, Julkunen Valtteri, Portaankorva Anne M, Mannermaa Arto, Soininen Hilkka, Jääskeläinen Juha E, Lambert Jean-Charles, Eide Per K, Palotie Aarno, Kurki Mitja I, Hiltunen Mikko, Leinonen Ville, Lipponen Anssi

APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease

基于APOE分层的全基因组关联研究为阿尔茨海默病的遗传病因学提供了新的见解

Thomassen, Jesper Qvist; Hampton, Leonard; Ulms, Brittany; Grenier-Boley, Benjamin; Heikkinen, Sami; Garcia, Pablo; Castillo-Morales, Atahualapa; Kikuchi, Masataka; Gim, Jungsoo; Cao, Han; Küçükali, Fahri; Amin, Najaf; Yoon, Dabin; de Rojas, Itziar; Jerez, Pilar Alvarez; Alvarez, Victoria; Arosio, Beatrice; Bellenguez, Celine; Bergh, Sverre; Billingsley, Kimberly; Blauwendraat, Cornelis; Boada, Merce; Borroni, Barbara; Bossù, Paola; Bullido, María J; Daniele, Antonio; Carracedo, Ángel; de Mendonça, Alexandre; Cookson, Mark; Deckert, Jürgen; Dichgans, Martin; Djurovic, Srdjan; Dols-Icardo, Oriol; Dufouil, Carole; Düzel, Emrah; Escott-Price, Valentina; Fladby, Tormod; Fratiglioni, Laura; Fu, Amy K Y; Galimberti, Daniela; García-Alberca, Jose Maria; Giedraitis, Vilmantas; Garcia-Ribas, Guillermo; Graff, Caroline; Grimmer, Timo; Grünblatt, Edna; Hanon, OIivier; Hausner, Lucrezia; Heilmann-Hemibach, Stefanie; Hort, Jakub; Jessen, Frank; Jensen, Kendall; Jonson, Caroline; Kim, Yoontae; Kuznetsov, Nicole; Leinonen, Ville; Lipponen, Anssi; Luo, Jiao; Makarious, Mary; Martiskainen, Henna; Masullo, Carlo; Mecocci, Patrizia; Mehrabian, Shima; Mir, Pablo; Miyashita, Akinori; Moebus, Susanne; Mok, Kin Y; Porcel, Laura Molina; Moreno, Fermin; Nacmias, Benedetta; Parnetti, Lucilla; Pastor, Pau; Pérez-Tur, Jordi; Peters, Oliver; Pijnenburg, Yolande A L; Piñol-Ripoll, Gerard; Popp, Julius; Rainero, Innocenzo; Real, Luis M; Riedel-Heller, Steffi; Rodriguez-Rodriguez, Eloy; Rongve, Arvid; Rossi, Giacomina; Royo, Jose Luis; Rujescu, Dan; Saltvedt, Ingvild; Sáez, María Eugenia; Sánchez-Valle, Raquel; Sanchez-Garcia, Florentino; Sandau, Nicolai; Scarmeas, Nikolaos; Scheffler, Katja; Scherbaum, Norbert; Schneider, Anja; Selbæk, Geir; Seripa, Davide; Solfrizzi, Vincenzo; Spallazzi, Marco; Squassina, Alessio; Stordal, Eystein; Tesi, Niccoló; Tremolizzo, Lucio; Tripathi, Kumar P; van der Flier, Wiesje M; Williams, Julie; Wiltfang, Jens; Aarsland, Dag; Singleton, Andrew B; Amouyel, Philippe; Debette, Stéphanie; Nicolas, Gael; van der Lee, Sven; Holstege, Henne; Fernandez, Maria Victoria; Kehoe, Patrick Gavin; Sleegers, Kristel; Ingelsson, Martin; Ghidoni, Roberta; Andreassen, Ole A; Holmans, Peter A; Sánchez-Juan, Pascual; Sims, Rebecca; Ip, Nancy Y; Lee, Kun Ho; Ikeuchi, Takeshi; Ramirez, Alfredo; Ruiz, Agustin; Hiltunen, Mikko; Lambert, Jean-Charles; van Duijn, Cornelia; Nalls, Mike; Frikke-Schmidt, Ruth

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation

用于预测欧洲人群中与年龄相关的阿尔茨海默病风险的多基因风险评分:开发和验证

Akdeniz, Bayram Cevdet; Bahrami, Shahram; Hagen, Espen; Fuhrer, Julian; Fominykh, Vera; Shadrin, Alexey; Filiz, Tahir Tekin; Athanasiu, Lavinia; Grenier-Boley, Benjamin; Bellenguez, Céline; de Rojas, Itziar; Küçükali, Fahri; Schneider, Anja; Kleineidam, Luca; Rujescu, Dan; Scherbaum, Norbert; Deckert, Jürgen; Riedel-Heller, Steffi; Hausner, Lucrezia; Molina-Porcel, Laura; Grimmer, Timo; Heilmann-Heimbach, Stefanie; Moebus, Susanne; Scarmeas, Nikolaos; García-Alberca, Jose María; Franco-Macías, Emilio; Mir, Pablo; Real, Luis M; Rodriguez-Rodriguez, Eloy; Royo, Jose Luís; Sáez, María Eugenia; Carracedo, Ángel; de Munain, Adolfo Lopez; Amer-Ferrer, Guillermo; Calero, Miguel; Medina, Miguel; Garcia-Ribas, Guillermo; Mendioroz, Maite; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Álvarez, Victoria; Soininen, Hilkka; Heikkinen, Sami; de Mendonça, Alexandre; Mehrabian, Shima; Traykov, Latchezar; Hort, Jakub; Vyhnalek, Martin; Sandau, Nicolai; Thomassen, Jesper Qvist; Luo, Jiao; Pijnenburg, Yolande A L; Tesi, Niccolo; van Swieten, John; Giedraitis, Vilmantas; Williams, Julie; Nicolas, Gael; Debette, Stephanie; Amouyel, Philippe; Grünblatt, Edna; Popp, Julius; Bossù, Paola; Galimberti, Daniela; Rossi, Giacomina; Arosio, Beatrice; Mecocci, Patrizia; Squassina, Alessio; Tremolizzo, Lucio; Borroni, Barbara; Nacmias, Benedetta; Seripa, Davide; Rainero, Innocenzo; Daniele, Antonio; Piras, Fabrizio; Masullo, Carlo; Kehoe, Patrick Gavin; Frikke-Schmidt, Ruth; Ghidoni, Roberta; Ruiz, Agustín; Fernandez, Victoria; Sánchez-Juan, Pascual; Sleegers, Kristel; Ingelsson, Martin; Hiltunen, Mikko; Sims, Rebecca; Ramirez, Alfredo; Broce, Iris J; Haavik, Jan; Selbæk, Geir; Knapskog, Anne-Brita; Saltvedt, Ingvild; Bergh, Sverre; Aakhus, Eivind; Kirsebom, Bjørn-Eivind; Watne, Leiv Otto; Rongve, Arvid; Årsland, Dag; Djurovic, Srdjan; Stordal, Eystein; Toft, Mathias; Scheffler, Katja; Fladby, Tormod; Lambert, Jean-Charles; Dale, Anders; Frei, Oleksandr; Andreassen, Ole

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

MGMT 和 BIN1 基因与阿尔茨海默病风险的关联性,不受性别和 APOE ε4 状态的影响

Le Borgne, Julie; Amouyel, Philippe; Andreassen, Ole; Frikke-Schmidt, Ruth; Hiltunen, Mikko; Ingelsson, Martin; Ramirez, Alfredo; Rossi, Giacomina; Ruiz, Agustin; Sanchez-Juan, Pascual; Sims, Rebecca; Sleegers, Kristel; Tsolaki, Magda; van der Lee, Sven J; Williams, Julie; Lambert, Jean-Charles; Bellenguez, Céline