日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii

弓形虫中可成药激酶TgGSK3的结构和功能表征

Diaz-Martin, Silvia; Swale, Christopher; Bellini, Valeria; Dobrescu, Irina; Wenker, Janine; Brenier-Pinchart, Marie-Pierre; Braun, Laurence; Tollec, Alwéna; Corrao, Charlotte; Couté, Yohann; Mas, Caroline; Laurent, Fabrice; Bowler, Matthew; Hakimi, Mohamed-Ali; Bougdour, Alexandre

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy.

发现用于检测慢性弓形虫病的生物标志物,揭示了影响寄生虫休眠的替代途径

Robert Marie G, Swale Christopher, Pachano Belen, Dépéry Léa, Bellini Valeria, Dard Céline, Cannella Dominique, Corrao Charlotte, Belmudes Lucid, Couté Yohann, Bougdour Alexandre, Pelloux Hervé, Chapey Emmanuelle, Wallon Martine, Brenier-Pinchart Marie-Pierre, Hakimi Mohamed-Ali

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

通过一系列ATP类似物靶向脯氨酰tRNA合成酶,加速弓形虫病药物的发现

Yogavel, Manickam; Bougdour, Alexandre; Mishra, Siddhartha; Malhotra, Nipun; Chhibber-Goel, Jyoti; Bellini, Valeria; Harlos, Karl; Laleu, Benoît; Hakimi, Mohamed-Ali; Sharma, Amit

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

双重药物靶向脯氨酰tRNA合成酶为抗感染药物研发提供了一种新的范式。

Manickam, Yogavel; Malhotra, Nipun; Mishra, Siddhartha; Babbar, Palak; Dusane, Abhishek; Laleu, Benoît; Bellini, Valeria; Hakimi, Mohamed-Ali; Bougdour, Alexandre; Sharma, Amit

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

弓形虫寄生泡膜相关致密颗粒蛋白调控慢性感染,而GRA12则维持对宿主γ干扰素的抵抗力。

Fox, Barbara A; Guevara, Rebekah B; Rommereim, Leah M; Falla, Alejandra; Bellini, Valeria; Pètre, Graciane; Rak, Camille; Cantillana, Viviana; Dubremetz, Jean-François; Cesbron-Delauw, Marie-France; Taylor, Gregory A; Mercier, Corinne; Bzik, David J

High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds

用于评估弓形虫感染和增殖的高内涵成像分析:一种用于筛选新化合物的多参数分析方法

Touquet, Bastien; Pelissier, Léonie; Cavailles, Pierre; Yi, Wei; Bellini, Valeria; Mercier, Corinne; Cesbron-Delauw, Marie-France; Boumendjel, Ahcène; Aldebert, Delphine

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii

毒力弓形虫中八个致密颗粒基因位点(GRA2-9)敲除相关的表型

Rommereim, Leah M; Bellini, Valeria; Fox, Barbara A; Pètre, Graciane; Rak, Camille; Touquet, Bastien; Aldebert, Delphine; Dubremetz, Jean-François; Cesbron-Delauw, Marie-France; Mercier, Corinne; Bzik, David J