日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

FRONTIER-3: a randomised phase 2a study to investigate tozorakimab, an anti-interleukin-33 monoclonal antibody, in early-onset asthma

FRONTIER-3：一项随机 IIa 期研究，旨在研究托佐拉单抗（一种抗白介素-33 单克隆抗体）治疗早发性哮喘的疗效

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00183-2025
Corren, Jonathan; Reid, Fred; Moate, Rachel; Jimenez, Eulalia; Sadiq, Muhammad Waqas; Williams, Adam; Rytelewski, Mateusz; Cameron-Christie, Sophia; Muthas, Daniel; Georgi, Benjamin; Brooks, Dennis; Lindqvist, Eva; Kell, Chris; Platt, Adam; Belvisi, Maria G; Pandya, Hitesh
单克隆抗体
哮喘
发表日期：2026
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Phase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA

一项 IIa 期随机、双盲、安慰剂对照研究，旨在评估 londamocitinib (AZD4604) 每日两次，持续 12 周，治疗中高剂量吸入性糖皮质激素-长效β2受体激动剂 (ICS-LABA) 控制不佳的中重度哮喘成人患者的疗效和安全性。

期刊:Bmj Open Respiratory Research
影响因子:3.4
doi:10.1136/bmjresp-2025-003589
Mustapa, Mohd Nubli; Hughes, Rod; Jensen, Tina J; Dosanjh, Davinder P; Konstantinidis, Kyriakos V; Jonsson, Julia; Nemes, Szilárd; Jevnikar, Zala; Jones, Michael; Adams, Amanda; Belvisi, Maria G; Akuthota, Praveen; Kocks, Janwillem W H
信号转导
哮喘
免疫/内分泌
发表日期：2026
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A phase 2a trial of the IL-33 monoclonal antibody tozorakimab in patients with COPD: FRONTIER-4

一项针对慢性阻塞性肺病患者的IL-33单克隆抗体tozorakimab的2a期临床试验：FRONTIER-4

期刊:European Respiratory Journal
影响因子:21
doi:10.1183/13993003.02231-2024
Singh, Dave; Guller, Patricia; Reid, Fred; Doffman, Sarah; Seppälä, Ulla; Psallidas, Ioannis; Moate, Rachel; Smith, Rebecca; Kiraga, Joanna; Jimenez, Eulalia; Brooks, Dennis; Kelly, Aoife; Nordenmark, Lars H; Sadiq, Muhammad Waqas; Caballero, Luis Mateos; Kell, Chris; Belvisi, Maria G; Pandya, Hitesh
单克隆抗体
IL-3
IL-33
发表日期：2025
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NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.

慢性阻塞性肺病患者的非典型流感嗜血杆菌（NTHi）杀菌活性降低，且与不同的微生物群有关

期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-025-03113-z
Gopalakrishnan Vancheswaran, Sparklin Ben, Kim Jung Hwan, Bouquet Jerome, Kehl Margaret, Kenny Tara, Morehouse Christopher, Caceres Carolina, Warrener Paul, Hristova Ventzislava A, Wilson Susan, Shandilya Harini, Barnes Arnita, Ruzin Alexey, Wang Junmin, Oberg Lisa, Angermann Bastian, McCrae Christopher, Platt Adam, Muthas Daniel, Hess Sonja, Tkaczyk Christine, Sellman Bret R, Ostridge Kristoffer, Belvisi Maria G, Wilkinson Tom M A, Staples Karl J, DiGiandomenico Antonio
微生物学
发表日期：2025
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A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055

一项评估豪猪蛋白酶抑制剂 AZD5055 的安全性、耐受性和药代动力学的 1 期研究

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.112602
Zhou, Xiao-Hong; Prothon, Susanne; L, Engin; Ferrari, Nicola; Hezaveh, Kebria; Liu, Zhi; Nemes, Szilard; Almquist, Joachim; Williams, Michael L; Sobande, Olami; Gottfridsson, Christer; Gochuico, Bernadette R; Platt, Adam; Brohawn, Zach; Belvisi, Maria G; Goldwater, Ronald; Hornberg, Ellinor; Owen, Caroline A
发表日期：2025
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Supporting clinical trial recruitment in COPD by leveraging lung cancer screening: an observational study

利用肺癌筛查支持慢性阻塞性肺病临床试验招募：一项观察性研究

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00024-2025
Patrick, Tanya; Naidu, Sindhu Bhaarrati; Bhamani, Amyn; Aboelhassan, Arafa; Caño, Silvia; Belvisi, Maria G; Doffman, Sarah R; Janes, Sam M; Hurst, John R
肺癌
肿瘤
肿瘤免疫
发表日期：2025
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A novel SPECT-CT imaging platform for quantifying in vivo lung cytokine signals in COPD

一种用于量化慢性阻塞性肺疾病患者体内肺部细胞因子信号的新型SPECT-CT成像平台

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.01246-2024
Welham, Benjamin; Bennett, Michael; Ostridge, Kristoffer; Guy, Matthew; Zvavamwe, Clint; Chilcott, Anna; Johns, Sandra; Sundram, Francis; Spalluto, Cosma M; Shaw, Emily; Harden, Stephen; Alzetani, Aiman; Lee, Paul; Lawson, Matthew; Lackie, Peter; Michopoulou, Sofia; Henley, Darren; Kong, Alex; Fazleen, Aishath; Cellura, Doriana; McCrae, Christopher; Platt, Adam; Belvisi, Maria G; Staples, Karl J; Wilkinson, Tom
信号转导
细胞生物学
慢性阻塞性肺疾病
免疫/内分泌
发表日期：2025
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Protocol for a double-blind crossover randomised controlled trial to investigate inhalation challenge to assess inducible laryngeal obstruction: CH-ILO

一项旨在研究吸入激发试验以评估诱发性喉阻塞的双盲交叉随机对照试验方案：CH-ILO

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00774-2024
Haines, Jemma; Belvisi, Maria G; Dubuis, Eric C; Dockry, Rachel J; Holt, Kimberley J; Hull, James H; Yorke, Janelle; Fowler, Stephen J; Smith, Jaclyn Ann
发表日期：2025
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Phase 2a, Randomized Trial of Mitiperstat Versus Placebo in Patients with COPD at High Risk of Exacerbation (CRESCENDO)

2a期随机试验，比较米替帕司他与安慰剂治疗高危慢性阻塞性肺疾病患者的疗效（CRESCENDO）

期刊:International Journal of Chronic Obstructive Pulmonary Disease
影响因子:3.1
doi:10.2147/COPD.S524775
Hughes, Rod; Brailsford, Wayne; Ferreira, João; Chalmers, James D; Belvisi, Maria G; Kocks, Janwillem W H; Masters, Pauline; Thomson, Paul; Łyżwa, Dawid; Rosengren, Sanna; Cooper, Jason David; Russell, Richard E K; Saralaya, Dinesh
慢性阻塞性肺疾病
发表日期：2025
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The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the Prospective Observational PROFILE Study

咳嗽对特发性肺纤维化患者的负担和影响：前瞻性观察性 PROFILE 研究的分析

期刊:Annals of the American Thoracic Society
影响因子:5.4
doi:10.1513/AnnalsATS.202302-174OC
Saunders, Peter; Wu, Zhe; Fahy, William A; Stewart, Iain D; Saini, Gauri; Smith, David J F; Braybrooke, Rebecca; Stock, Carmel; Renzoni, Elisabetta A; Johnson, Simon R; Jenkins, R Gisli; Belvisi, Maria G; Smith, Jaclyn A; Maher, Toby M; Molyneaux, Philip L
特发性肺纤维化
发表日期：2023
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