日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress

BCL6 的进化使脊椎动物能够耐受压力,并且是癌细胞适应压力所必需的

Tharu M Fernando #, Rossella Marullo #, Benet Pera Gresely, Jude M Phillip, Shao Ning Yang, Geoffrey Lundell-Smith, Ingrid Torregroza, Haelee Ahn, Todd Evans, Balázs Győrffy, Gilbert G Privé, Masayuki Hirano, Ari M Melnick, Leandro Cerchietti

Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway

代谢组学分析揭示赖氨酸脱乙酰酶抑制剂通过胆碱途径对 B 细胞淋巴瘤进行细胞重编程

Benet Pera, Jan Krumsiek, Sarit E Assouline, Rossella Marullo, Jayeshkumar Patel, Jude M Phillip, Lidia Román, Koren K Mann, Leandro Cerchietti

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

THZ1 靶向 CDK7 可抑制 STAT 转录活性并使 T 细胞淋巴瘤对 BCL2 抑制剂敏感

Florencia Cayrol, Pannee Praditsuktavorn, Tharu M Fernando, Nicholas Kwiatkowski, Rosella Marullo, M Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathan

BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models

BO-1055 是一种新型 DNA 交联剂,具有极低的骨髓毒性,在肉瘤模型中表现出强效活性

Srikanth R Ambati, Jae-Hung Shieh, Benet Pera, Eloisi Caldas Lopes, Anisha Chaudhry, Elissa W P Wong, Ashish Saxena, Tsann-Long Su, Malcolm A S Moore

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules

Zampanolide 是一种新型强效微管稳定剂,可与微管蛋白 α、β-异二聚体和微管中的紫杉烷腔内位点发生共价反应

Jessica J Field, Benet Pera, Enrique Calvo, Angeles Canales, Didier Zurwerra, Chiara Trigili, Javier Rodríguez-Salarichs, Ruth Matesanz, Arun Kanakkanthara, St John Wakefield, A Jonathan Singh, Jesús Jiménez-Barbero, Peter Northcote, John H Miller, Juan Antonio López, Ernest Hamel, Isabel Barasoain,