日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways

基于BioID2的Tau蛋白相互作用组揭示了与多种细胞通路相关的新型和已知蛋白质相互作用

Ahmed Atwa ,Mohammed M Alhadidy ,Jared Lamp ,Benjamin Combs ,Nicholas M Kanaan

Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons

Tau 中 Ser199/Ser202/Thr205 位点的磷酸化模拟物会损害大鼠海马神经元的轴突运输

Kyle R Christensen #, Benjamin Combs #, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaan

Age-dependent accumulation of tau aggregation in Caenorhabditis elegans

秀丽隐杆线虫中 tau 聚集的年龄依赖性积累

Wendy Aquino Nunez, Benjamin Combs, T Chris Gamblin, Brian D Ackley

Neurocognitive Outcomes in Pediatric Patients Following Brain Irradiation

儿童脑部放射治疗后的神经认知结果

Weusthof, Katharina; Lüttich, Peggy; Regnery, Sebastian; König, Laila; Bernhardt, Denise; Witt, Olaf; Herfarth, Klaus; Unterberg, Andreas; Jungk, Christine; Farnia, Benjamin; Combs, Stephanie E; Debus, Jürgen; Rieken, Stefan; Harrabi, Semi; Adeberg, Sebastian

Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism

额颞叶痴呆突变型tau蛋白通过蛋白磷酸酶1γ依赖性机制损害轴突运输。

Benjamin Combs,Kyle R Christensen,Collin Richards,Andrew Kneynsberg,Rebecca L Mueller,Sarah L Morris,Gerardo A Morfini,Scott T Brady,Nicholas M Kanaan

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

液-液相分离在体外诱导致病性 tau 构象

Nicholas M Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Combs

Production of recombinant tau oligomers in vitro

体外重组 tau 寡聚体的产生

Benjamin Combs, Chelsea T Tiernan, Chelsey Hamel, Nicholas M Kanaan

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies

阿尔茨海默病早期即可出现涉及tau蛋白氨基末端的病理构象,这些构象可通过单克隆抗体进行差异性检测。

Benjamin Combs ,Chelsey Hamel ,Nicholas M Kanaan

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport

tau蛋白S422位点的假磷酸化增强了SDS稳定二聚体的形成,并损害了顺行和逆行快速轴突运输。

Chelsea T Tiernan ,Benjamin Combs ,Kristine Cox ,Gerardo Morfini ,Scott T Brady ,Scott E Counts ,Nicholas M Kanaan

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition

异构体特异性 tau 聚集体的分析表明,存在一种常见的毒性机制,涉及相似的病理构象和轴突运输抑制

Kristine Cox, Benjamin Combs, Brenda Abdelmesih, Gerardo Morfini, Scott T Brady, Nicholas M Kanaan