日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy

反义寡核苷酸介导的基因敲低疗法治疗两名患有严重KCNT1癫痫性脑病的婴儿

Nakayama, Tojo; El Achkar, Christelle M; Burbano, Lisseth E; Quraishi, Imran H; Wu, Jing; Li, Melody; Asami, Yutaro; Golinski, Sean R; Sherrill, Emma; Goodlett, Benjamin D; de Gusmao, Claudio M; Friedman, Danielle A; Lentucci, Claudia; Suslovitch, Victoria; Riccardi, Olivia; Faour, Kamli N W; Kuniholm, Ashley; Soucy Verran, Aubrie; Coffman, Siobhan; Ahtam, Banu; Zhao, Boxun; Chin, Diana H; DiDonato, Renata L; Hu, Chunguang A; Lopez, Edith; Hills, Sonia; Maljevic, Snezana; Tran, Helene; Bush, Lynn W; Grant, Patricia Ellen; Madsen, Joseph R; Smith, Richard S; Kaczmarek, Leonard K; Berde, Charles B; Yu, Timothy W

Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion.

进食调节的糖原代谢驱动肝脏蛋白质的节律性分泌。

Weger Meltem, Mauvoisin Daniel, Hoyle Dominic, Wang Jingkui, Martin Eva, Rae James, Ferguson Charles, Klinke Glynis, Cielesh Michelle, Macauslane Kyle L, Larance Mark, Quadroni Manfredo, Templeman Iain, Walhin Jean-Philippe, Karagounis Leonidas G, Betts James A, Johnston Jonathan D, Durussel Fanny, Firsov Dmitri, Fournier Stephane, Müller Olivier, Schulz Benjamin L, Parton Robert G, Weger Benjamin D, Gachon Frédéric

Phased-assembly-driven pangenome graphs for structural variant genotyping and complex trait mapping in dairy cattle

基于阶段组装的泛基因组图谱用于奶牛结构变异基因分型和复杂性状定位

Yang, Liu; Gao, Yahui; Kuhn, Kristen L; Bhowmik, Nayan; Li, Wenli; Zanton, Geoffrey; Fang, Lingzhao; Cole, John B; Li, Congjun; Baldwin Vi, Ransom L; Van Tassell, Curtis P; Rosen, Benjamin D; Ma, Li; Smith, Timothy P L; Liu, George E

Antecedent enhancer activity predicts future susceptibility to seizures in mice

前驱增强子活性可预测小鼠未来对癫痫的易感性

Boros, Benjamin D; Gachechiladze, Mariam A; Guo, Juanru; Galloway, Dylan A; Mueller, Shayna M; Shabsovich, Mark; Yen, Allen; Chen, Xuhua; Cammack, Alexander J; Shen, Tao; Mitra, Robi D; Dougherty, Joseph D; Miller, Timothy M

Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.

顺式调控元件的鉴定有助于深入了解绵羊基因组中的组织特异性基因调控。

Xie Shangqian, Davenport Kimberly M, Salavati Mazdak, Caulton Alex, Clark Emily L, Archibald Alan L, Clarke Shannon M, Brauning Rudiger, Massa Alisha T, Mousel Michelle R, White Stephen N, Worley Kim C, Murdoch Gordon K, Becker Gabrielle, Stegmiller Morgan R, Khilji Sarem F, Shira Katie A, Olagunju Temitayo A, Hadfield Tracy, McKay Stephanie D, Rosen Benjamin D, Cockett Noelle E, Smith Timothy P L, Murdoch Brenda M

Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.

在 ART 中断之前增强 SIV 特异性 CD8+ T 细胞反应可延长 SIVmac239 反弹的时间。

Omange Were R, Varco-Merth Benjamin D, Fadeyi Omo, Marenco Alejandra, Takata Hiroshi, Duell Derick M, Goodwin William D, Armitage Paula, Fennessey Christine M, Kose Emek, Immonen Taina T, Kosmider Ewelina, Bosche William J, Fast Randy, Homick Chris, Oswald Kelli, Shoemaker Rebecca, Bochart Rachele, MacAllister Rhonda, Labriola Caralyn S, Smedley Jeremy V, Axthelm Michael K, Edlefsen Paul T, Keele Brandon F, Lifson Jeffrey D, Gergen Janina, Petsch Benjamin, Rauch Susanne, Picker Louis J, Okoye Afam A

PDGFRβ signaling restrains myocyte function to limit the regenerative capacity of skeletal muscle.

PDGFRβ信号传导抑制肌细胞功能,从而限制骨骼肌的再生能力。

Xue Siwen, Benvie Abigail M, Blum Jamie E, Cosgrove Benjamin D, Thalacker-Mercer Anna E, Berry Daniel C

Secretory kinase FAM20C triggers adipocyte dysfunction, inciting insulin resistance and inflammation in obesity.

分泌型激酶 FAM20C 可引发脂肪细胞功能障碍,从而导致肥胖症中的胰岛素抵抗和炎症。

Gilani Ankit, Stein Benjamin D, Hoffmann Anne, Pereira de Lima Renan, Ha Elizabeth E, Homan Edwin A, Ma Lunkun, Rubio-Navarro Alfonso, Tha Ra Wun Tint, Ayala Carrascal Gabriel Jose, Bhinder Bhavneet, Ghosh Adhideb, Noé Falko, Elemento Olivier, Wolfrum Christian, Blüher Matthias, Lo James C

Long read and preliminary pangenome analyses reveal breed-specific structural variations and novel sequences in Holstein and Jersey cattle

长读长测序和初步泛基因组分析揭示了荷斯坦牛和泽西牛品种特异性的结构变异和新序列。

Gao, Yahui; Yang, Liu; Kuhn, Kristen; Li, Wenli; Zanton, Geoffrey; Bowman, Mary; Zhao, Pengju; Zhou, Yang; Fang, Lingzhao; Cole, John B; Rosen, Benjamin D; Ma, Li; Li, Congjun; Baldwin, Ransom L 6th; Van Tassell, Curtis P; Zhang, Zhe; Smith, Timothy P L; Liu, George E

α-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction.

α-突触核蛋白的表达是胞体树突多巴胺释放和即刻早期基因诱导所必需的。

Choi Se Joon, Frank Anika, Ben-Johny Manu, Tang Guomei, Bendig Jonas, Fanourakis Stavros, Hobson Benjamin D, Ramalingam Nagendran, Dettmer Ulf, Kanter Ellen, Sulzer David, Mosharov Eugene V