日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species

脑室周围小胶质细胞对α-突触核蛋白毒性物质的早期反应中,清除能力随年龄增长而逐渐减弱,最终变得脆弱。

Mª Salomé Sirerol-Piquer # ,Ana Perez-Villalba # ,Pere Duart-Abadia # ,Germán Belenguer ,Ulises Gómez-Pinedo ,Laura Blasco-Chamarro ,Pau Carrillo-Barberà ,Azucena Pérez-Cañamás ,Victoria Navarro-Garrido ,Benjamin Dehay ,Miquel Vila ,Javier Vitorica ,Francisco Pérez-Sánchez ,Isabel Fariñas

Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation

阿尔茨海默病患者大脑中的 Tau 种子会引发恒河猴体内的 Tau 扩散,而寡聚 Aβ 则会介导病理成熟

Morgane Darricau, Changsong Dou, Remi Kinet, Tao Zhu, Li Zhou, Xianglei Li, Aurélie Bedel, Stéphane Claverol, Caroline Tokarski, Taxiarchis Katsinelos, William A McEwan, Ling Zhang, Ran Gao, Mathieu Bourdenx, Benjamin Dehay, Chuan Qin, Erwan Bezard, Vincent Planche

Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates

在一项针对非人类灵长类动物的初步研究中,黑质 ATP13A2 耗竭会诱发帕金森病相关的神经退行性病变

Joanna Sikora #, Sandra Dovero #, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay

Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates

患者的 Tau 种子在灵长类动物中诱发进行性核上性麻痹病理和症状

Morgane Darricau, Taxiarchis Katsinelos, Flavio Raschella, Tomislav Milekovic, Louis Crochemore, Qin Li, Grégoire Courtine, William A McEwan, Benjamin Dehay, Erwan Bezard, Vincent Planche

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain

皮质路易体注射可在非人类灵长类动物大脑中诱发长距离致病改变

Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A Obeso, Erwan Bezard #, Benjamin Dehay #

Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function

酸性纳米粒子通过恢复溶酶体功能来预防 α-突触核蛋白诱发的神经变性

Marie-Laure Arotcarena, Federico N Soria, Anthony Cunha, Evelyne Doudnikoff, Geoffrey Prévot, Jonathan Daniel, Mireille Blanchard-Desce, Philippe Barthélémy, Erwan Bezard, Sylvie Crauste-Manciet, Benjamin Dehay

Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study

海藻糖基核脂作为纳米载体调节自噬:一项体外研究

Anthony Cunha, Alexandra Gaubert, Julien Verget, Marie-Laure Thiolat, Philippe Barthélémy, Laurent Latxague, Benjamin Dehay

The Zinc Ionophore Clioquinol Reduces Parkinson's Disease Patient-Derived Brain Extracts-Induced Neurodegeneration

锌离子载体氯碘羟喹可减轻帕金森病患者脑提取物诱发的神经退行性病变

Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Dehay

Involvement of Autophagy in Levodopa-Induced Dyskinesia

自噬在左旋多巴诱发的运动障碍中的作用

Michael Feyder #, Carina Plewnia #, Ori J Lieberman, Giada Spigolon, Alessandro Piccin, Lidia Urbina, Benjamin Dehay, Qin Li, Per Nilsson, Mikael Altun, Emanuela Santini, David Sulzer, Erwan Bezard, Anders Borgkvist, Gilberto Fisone

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques

初步研究评估鞘内注射变体 AAV-PHP.B 和 AAV-PHP.eB 对成年恒河猴脑传导的影响

Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay