日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor

通过腺相关病毒(AAV)介导递送工程化紧凑型表观遗传编辑器,实现全脑朊病毒蛋白的沉默。

Edwin N Neumann # ,Tessa M Bertozzi # ,Elaine Wu ,Fiona Serack ,John W Harvey ,Pamela P Brauer ,Catherine P Pirtle ,Alissa Coffey ,Michael Howard ,Nikita Kamath ,Kenney Lenz ,Kenia Guzman ,Michael H Raymond ,Ahmad S Khalil ,Benjamin E Deverman ,Eric Vallabh Minikel ,Sonia M Vallabh ,Jonathan S Weissman

Systematic multi-trait AAV capsid engineering for efficient gene delivery

系统性多性状AAV衣壳工程改造以实现高效基因递送

Fatma-Elzahraa Eid ,Albert T Chen ,Ken Y Chan ,Qin Huang ,Qingxia Zheng ,Isabelle G Tobey ,Simon Pacouret ,Pamela P Brauer ,Casey Keyes ,Megan Powell ,Jencilin Johnston ,Binhui Zhao ,Kasper Lage ,Alice F Tarantal ,Yujia A Chan ,Benjamin E Deverman

Spatial atlas of the mouse central nervous system at molecular resolution

分子分辨率的小鼠中枢神经系统空间图谱

Hailing Shi #, Yichun He #, Yiming Zhou #, Jiahao Huang, Kamal Maher, Brandon Wang, Zefang Tang, Shuchen Luo, Peng Tan, Morgan Wu, Zuwan Lin, Jingyi Ren, Yaman Thapa, Xin Tang, Ken Y Chan, Benjamin E Deverman, Hao Shen, Albert Liu, Jia Liu, Xiao Wang

Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier

通过设计能够穿过血脑屏障的衣壳受体相互作用,将 AAV 载体靶向中枢神经系统

Qin Huang, Albert T Chen, Ken Y Chan, Hikari Sorensen, Andrew J Barry, Bahar Azari, Qingxia Zheng, Thomas Beddow, Binhui Zhao, Isabelle G Tobey, Cynthia Moncada-Reid, Fatma-Elzahraa Eid, Christopher J Walkey, M Cecilia Ljungberg, William R Lagor, Jason D Heaney, Yujia A Chan, Benjamin E Deverman

A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System

一种用于中枢神经系统内皮细胞转导的高效 AAV

Trevor Krolak, Ken Y Chan, Luke Kaplan, Qin Huang, Jason Wu, Qingxia Zheng, Velina Kozareva, Thomas Beddow, Isabelle G Tobey, Simon Pacouret, Albert T Chen, Yujia A Chan, Daniel Ryvkin, Chenghua Gu, Benjamin E Deverman

Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery

使用高内涵成像来量化系统性给药后 AAV-PHP 病毒在脑内的转导

Edward J Smith, Pamela P Farshim, Rachel Flomen, Samuel T Jones, Sean J McAteer, Benjamin E Deverman, Viviana Gradinaru, Gillian P Bates

Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann-Pick disease type C1 mice

使用神经营养衣壳对尼曼匹克病 C1 型小鼠进行改进的系统性 AAV 基因治疗

Cristin D Davidson, Alana L Gibson, Tansy Gu, Laura L Baxter, Benjamin E Deverman, Keith Beadle, Arturo A Incao, Jorge L Rodriguez-Gil, Hideji Fujiwara, Xuntian Jiang, Randy J Chandler, Daniel S Ory, Viviana Gradinaru, Charles P Venditti, William J Pavan

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

多重 Cre 依赖性选择产生系统性 AAV,用于靶向不同的脑细胞类型

Sripriya Ravindra Kumar, Timothy F Miles #, Xinhong Chen #, David Brown, Tatyana Dobreva, Qin Huang, Xiaozhe Ding, Yicheng Luo, Pétur H Einarsson, Alon Greenbaum, Min J Jang, Benjamin E Deverman, Viviana Gradinaru

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

利用光遗传学和病毒载体策略鉴定调节心率的外周神经回路

Pradeep S Rajendran ,Rosemary C Challis ,Charless C Fowlkes ,Peter Hanna ,John D Tompkins ,Maria C Jordan ,Sarah Hiyari ,Beth A Gabris-Weber ,Alon Greenbaum ,Ken Y Chan ,Benjamin E Deverman ,Heike Münzberg ,Jeffrey L Ardell ,Guy Salama ,Viviana Gradinaru ,Kalyanam Shivkumar

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

跨越血脑屏障传递基因:LY6A,一种新型 AAV-PHP.B 衣壳细胞受体

Qin Huang, Ken Y Chan, Isabelle G Tobey, Yujia Alina Chan, Tim Poterba, Christine L Boutros, Alejandro B Balazs, Richard Daneman, Jonathan M Bloom, Cotton Seed, Benjamin E Deverman