日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes

长期体重指数变化与不良心血管后果

Zakaria Almuwaqqat, Qin Hui, Chang Liu, Jin J Zhou, Benjamin F Voight, Yuk-Lam Ho, Daniel C Posner, Jason L Vassy, J Michael Gaziano, Kelly Cho, Peter W F Wilson, Yan V Sun

GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density

基于 GWAS 的数据整合和非编码 CRISPRi 筛查阐明了骨密度的遗传病因

Mitchell Conery, James A Pippin, Yadav Wagley, Khanh Trang, Matthew C Pahl, David A Villani, Lacey J Favazzo, Cheryl L Ackert-Bicknell, Michael J Zuscik, Eugene Katsevich, Andrew D Wells, Babette S Zemel, Benjamin F Voight, Kurt D Hankenson, Alessandra Chesi, Struan F A Grant

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

通过基因表达模式预测遗传关联,可以揭示疾病病因和药物机制。

Milton Pividori,Sumei Lu,Binglan Li,Chun Su,Matthew E Johnson,Wei-Qi Wei,Qiping Feng,Bahram Namjou,Krzysztof Kiryluk,Iftikhar J Kullo,Yuan Luo,Blair D Sullivan,Benjamin F Voight,Carsten Skarke,Marylyn D Ritchie,Struan F A Grant

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

表观基因组学和转录组学分析确定了肾脏疾病的核心细胞类型、基因和可靶向机制

Hongbo Liu, Tomohito Doke, Dong Guo, Xin Sheng, Ziyuan Ma, Joseph Park, Ha My T Vy, Girish N Nadkarni, Amin Abedini, Zhen Miao, Matthew Palmer, Benjamin F Voight, Hongzhe Li, Christopher D Brown, Marylyn D Ritchie, Yan Shu, Katalin Susztak6

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

将人类特征的遗传结构映射到肾脏中的细胞类型可以确定疾病的机制和潜在的治疗方法

Xin Sheng #, Yuting Guan #, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, Zhen Miao, Matthew J Seasock, Matthew Palmer, Myung K Shin, Kevin L Duffin, Steven S Pullen, Todd L Edwards, Jacklyn N Hellwege, Adriana M Hung, Mingyao Li, Benjamin F Voight, Thomas M Coffman, Christopher D

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

单个基因位点通过铁死亡控制DPEP1/CHMP1A的表达和肾脏疾病的发生发展。

Yuting Guan # ,Xiujie Liang # ,Ziyuan Ma ,Hailong Hu ,Hongbo Liu ,Zhen Miao ,Andreas Linkermann ,Jacklyn N Hellwege ,Benjamin F Voight ,Katalin Susztak

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

人类胚胎干细胞来源的下丘脑神经元分化的顺式调控结构有助于相关复杂性状的变异基因定位

Matthew C Pahl # ,Claudia A Doege # ,Kenyaita M Hodge # ,Sheridan H Littleton # ,Michelle E Leonard ,Sumei Lu ,Rick Rausch ,James A Pippin ,Maria Caterina De Rosa ,Alisha Basak ,Jonathan P Bradfield ,Reza K Hammond ,Keith Boehm ,Robert I Berkowitz ,Chiara Lasconi ,Chun Su ,Alessandra Chesi ,Matthew E Johnson ,Andrew D Wells ,Benjamin F Voight ,Rudolph L Leibel ,Diana L Cousminer ,Struan F A Grant

Single-cell analysis reveals that noncoding RNAs contribute to clonal heterogeneity by modulating transcription factor recruitment

单细胞分析表明非编码 RNA 通过调节转录因子募集导致克隆异质性

Stacie L Bumgarner, Gregor Neuert, Benjamin F Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R Fink