日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

通过将AsCas12a敲入小鼠与超紧凑筛选相结合,推进基因工程工具箱的发展

Wei Jin # ,Yexuan Deng # ,John E La Marca # ,Emily J Lelliott ,Sarah T Diepstraten ,Christina König ,Lin Tai ,Valentina Snetkova ,Kristel M Dorighi ,Luke Hoberecht ,Millicent G Hedditch ,Lauren Whelan ,Geraldine Healey ,Dan Fayle ,Kieran Lau ,Margaret A Potts ,Moore Z Chen ,Angus P R Johnston ,Yang Liao ,Wei Shi ,Andrew J Kueh ,Benjamin Haley ,Jean-Philippe Fortin ,Marco J Herold

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation

用于超高动态范围基因扰动的化学诱导型 CRISPR/Cas9 回路

Rajini Srinivasan #,Tao Sun #,Azalia Sandles,Diana Wu,Liang Wang,Hetal Patel,Ryan Pabalate,Maram Bader,Amy Heidersbach,Clark Ho,Shiqi Xie,Andrew Ng,Benjamin Haley

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity

CRISPR/Cas9筛选揭示了内体-高尔基体界面上的蛋白质,这些蛋白质能够调节细胞反义寡核苷酸的活性。

Liza Malong ,Jessica Roskosch ,Carolina Hager ,Jean-Philippe Fortin ,Roland Schmucki ,Marinella G Callow ,Christian Weile ,Valentina Romeo ,Christoph Patsch ,Scott Martin ,Mike Costa ,Zora Modrusan ,Roberto Villaseñor ,Erich Koller ,Benjamin Haley ,Anne Spang ,Filip Roudnicky

COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway

BRAFV600E黑色素瘤中COP1缺陷导致对MAPK通路抑制剂的耐药性

Ada Ndoja,Christopher M Rose,Eva Lin,Rohit Reja,Jelena Petrovic,Sarah Kummerfeld,Andrew Blair,Helen Rizos,Zora Modrusan,Scott Martin,Donald S Kirkpatrick,Amy Heidersbach,Tao Sun,Benjamin Haley,Ozge Karayel,Kim Newton,Vishva M Dixit

Transcription factor Zfx regulates tumor's evasion to T cell killing in immunotherapy

转录因子Zfx调控肿瘤在免疫治疗中逃避T细胞杀伤的作用

Ulrike Kaufmann ,Joy Wang ,Marinella G Callow ,Jean-Philippe Fortin ,Szymon Myrta ,Dorothee Nickles ,Rohit Reja ,Eric Cheng ,Erin Wonder ,Benjamin Haley ,Yuxin Liang ,Scott Martin ,Mike Costa ,Haochu Huang

Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types

系统性地发现患者和肿瘤类型间共享的新抗原的新表位-HLA配对

Hem R Gurung #,Amy J Heidersbach #,Martine Darwish #,Pamela Pui Fung Chan,Jenny Li,Maureen Beresini,Oliver A Zill,Andrew Wallace,Ann-Jay Tong,Dan Hascall,Eric Torres,Andy Chang,Kenny 'Hei-Wai' Lou,Yassan Abdolazimi,Christian Hammer,Ana Xavier-Magalhães,Ana Marcu,Samir Vaidya,Daniel D Le,Ilseyar Akhmetzyanova,Soyoung A Oh,Amanda J Moore,Uzodinma N Uche,Melanie B Laur,Richard J Notturno,Peter J R Ebert,Craig Blanchette,Benjamin Haley,Christopher M Rose

Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage

核苷酸修饰可通过阻断 RNase 切割来合理设计 TLR7 选择性配体

Ann-Jay Tong #, Rebecca Leylek #, Anna-Maria Herzner #, Diamanda Rigas, Sara Wichner, Craig Blanchette, Siri Tahtinen, Christopher C Kemball, Ira Mellman, Benjamin Haley, Emily C Freund #, Lélia Delamarre #

In situ tumour arrays reveal early environmental control of cancer immunity

原位肿瘤阵列揭示癌症免疫的早期环境控制

Guadalupe Ortiz-Muñoz #, Markus Brown #, Catherine B Carbone #, Ximo Pechuan-Jorge #, Vincent Rouilly, Henrik Lindberg, Alex T Ritter, Gautham Raghupathi, Qianbo Sun, Tess Nicotra, Shreya R Mantri, Angela Yang, Jonas Doerr, Deepti Nagarkar, Spyros Darmanis, Benjamin Haley, Sanjeev Mariathasan, Yulei

TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage

TEAD 蛋白与 DNA 修复蛋白结合,促进细胞从 DNA 损伤中恢复

Philamer C Calses, Victoria C Pham, Alissa D Guarnaccia, Meena Choi, Erik Verschueren, Sietske T Bakker, Trang H Pham, Trent Hinkle, Chad Liu, Matthew T Chang, Noelyn Kljavin, Corey Bakalarski, Benjamin Haley, Jianing Zou, Cuicui Yan, Xia Song, Xiaoyan Lin, Rebecca Rowntree, Alan Ashworth, Anwesha D

Optimized Nonviral Gene Disruption in Primary Murine and Human Myeloid Cells

小鼠和人类原代髓系细胞中优化的非病毒基因破坏

Emily C Freund, Simone M Haag, Benjamin Haley, Aditya Murthy